Magnetic resonance imaging and relaxometry to study water transport mechanisms in a commercially available gastrointestinal therapeutic system (GITS) tablet

Broadbent, Amber L.; Fell, Rob J.; Codd, Sarah L.; Lightley, Kim A.; Konagurthu, Sanjay; Koehler-King, Dory G.; Seymour, Joseph D.

doi:10.1016/j.ijpharm.2010.06.047

Cited by 15 publications

(3 citation statements)

References 20 publications

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“…Here we present a combination of localized nuclear magnetic resonance (NMR) spectroscopy and NMR imaging techniques , which allow in situ investigation of the drug under these particular conditions. These techniques are often used, though typically for observing the water and water dynamics in pharmaceutical formulations. − As we demonstrate below, the state of the drug can also be monitored during tablet disintegration and dissolution. In particular, we observe drug recrystallization from the initial state identified as amorphous nanoparticle.…”

Section: Introductionmentioning

confidence: 99%

Polymer Swelling, Drug Mobilization and Drug Recrystallization in Hydrating Solid Dispersion Tablets Studied by Multinuclear NMR Microimaging and Spectroscopy

et al. 2011

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Despite the advantages offered by solid dispersions, the marketed products based on this technology are few. The most frequent concern is the stability of the amorphous drug. The state of the drug in solid dispersions is, in general, poorly characterized as the number of characterization techniques available to monitor nanometer-sized drug particles embedded in a matrix are limited. Here we present a combination of localized NMR spectroscopic and NMR imaging techniques which allow in situ monitoring of the state of the drug during tablet disintegration and dissolution. (19)F NMR relaxation is shown to be sensitive to both the crystalline/amorphous state and the size of the model nanoparticles made of the drug substance flutamide. The time course of drug mobilization and recrystallization is detected with spatial resolution within swelling solid dispersion tablets. Comparing results from spatially resolved (19)F, (2)H and (1)H NMR experiments, recrystallization is related to its enabling factors such as local hydration level and local mobility of the polymer matrix. The initially amorphous drug may recrystallize either by nanoparticle coalescence or by ripening of crystalline grains.

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Section: Introductionmentioning

confidence: 99%

Polymer Swelling, Drug Mobilization and Drug Recrystallization in Hydrating Solid Dispersion Tablets Studied by Multinuclear NMR Microimaging and Spectroscopy

et al. 2011

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“…Paracetamol [220] Structural changes in tablets during disintegration Ibuprofen [221] Water transport mechanism Cardura XL (doxazocin) [222] Acoustic emission Estimation of particle size, flowability and compressibility of high shear granulation process On-line [223] Monitoring of lubricant addition / blending…”

Section: Screening Of Enteric Coatings Propertiesmentioning

confidence: 99%

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Arshad

Zafar

Yousef

et al. 2021

Advanced Drug Delivery Reviews

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“…For an overview, see, for example, Codd et al (2006). These techniques have been widely used to study flow and mass transport through a large number of different materials including, for example, colloidal suspensions (Brown et al, 2007(Brown et al, , 2009Kaneda et al, 2009), foams (Brosten et al, 2009a(Brosten et al, , 2010, porous ceramic (Brosten et al, 2009b), biofilms and biofilmcovered capillaries (Hornemann et al, 2008(Hornemann et al, , 2009, and tablets (Broadbent et al, 2010). 129 Xe Spy Detection.…”

Section: Liquid-state Nmr In Materials Sciencementioning

confidence: 99%

Nuclear Magnetic Resonance: Basic Principles and Liquid State Spectroscopy

Hoffmann

2012

Characterization of Materials

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Thermogravimetric analysis (TGA) is an analytical technique for measuring changes in the mass of a material that occur in response to programmed temperature changes. The changes in the mass can be caused by a variety processes such as decomposition, degradation, sublimation, vaporization, adsorption, desorption, oxidation, and reduction. The article explains the principles of TGA and practical aspects of the method that include description of the apparatus, discussion of experimental variables, and applications. Among practical applications, a particular attention is paid to determining composition and thermal stability of materials, evaluating the kinetics of thermally stimulated processes, predicting lifetimes, and studying reactions of materials with gases. The article also addresses the issues of sample preparation as well as of basic analysis and interpretation of data. A special consideration is given to the sources of errors in the mass and temperature measurements as well as to the methods of calibrating both values.

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Magnetic resonance imaging and relaxometry to study water transport mechanisms in a commercially available gastrointestinal therapeutic system (GITS) tablet

Cited by 15 publications

References 20 publications

Polymer Swelling, Drug Mobilization and Drug Recrystallization in Hydrating Solid Dispersion Tablets Studied by Multinuclear NMR Microimaging and Spectroscopy

Polymer Swelling, Drug Mobilization and Drug Recrystallization in Hydrating Solid Dispersion Tablets Studied by Multinuclear NMR Microimaging and Spectroscopy

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Nuclear Magnetic Resonance: Basic Principles and Liquid State Spectroscopy

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