Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablation of liver tumours

Abstract

Recent decades have seen a paradigm shift in the treatment of liver tumours from invasive surgical procedures to minimally invasive image-guided ablation techniques. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a novel, completely non-invasive ablation technique that has the potential to change the field of liver tumour ablation. The image guidance, using MR imaging and MR temperature mapping, provides excellent planning images and real-time temperature information during the ablation procedure. However, before clinical implementation of MR-HIFU for liver tumour ablation is feasible, several organ-specific challenges have to be addressed. In this review we discuss the MR-HIFU ablation technique, the liver-specific challenges for MR-HIFU tumour ablation, and the proposed solutions for clinical translation.

Enhancing photothermal cancer therapy by clustering gold nanoparticles into spherical polymeric nanoconstructs

“…Different energy sources have been employed to induce the thermal ablation of biological tissues including laser-based techniques [3], radiofrequency systems [4], high-intensity focused ultrasound [5], and alternating magnetic field generators [6]. Some of these approaches have been successfully translated into a clinical setting.…”

Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS)in vitroandin vivo

“…Numerous studies and clinical trials have used HIFU to treat local diseases in organs such as the thyroid, prostate, breast, pancreas and liver (Esnault et al 2011, Warmuth et al 2010, Peek et al 2015, Jang et al 2010, Wijlemans et al 2012). The clinical translation and accessibility of HIFU relies heavily on improving its treatment monitoring.…”

“…Magnetic resonance imaging (MRI) thermometry (Dibaji et al 2014; McDannold et al 2000) is used to detect temperature rise across the treatment area. However, MRI guidance can be expensive and time consuming compared to ultrasound-based HIFU guidance; the temporal resolution for this clinical applications is usually between 2 and 6 s (Wijlemans et al 2012). Among the ultrasound guidance techniques, conventional B-mode-based ‘hyperecho’ tracking is not robust for HIFU monitoring as it is sensitive to air bubbles, which occur at high temperatures and usually lead to over-treatment of the targeted region (Yu and Xu 2008, Ueno et al 1990).…”

High-Intensity Focused Ultrasound Leads to Histopathologic Changes of the Inferior Turbinate Mucosa with Allergic Inflammation

“…High-intensity focused ultrasound (HIFU) has been increasingly accepted as a treatment for benign or malignant solid tumors in the past decade (Khokhlova and Hwang 2011;Klingler et al 2008;Li et al 2010;Napoli et al 2013;Park et al 2013;Wang et al 2012;Wijlemans et al 2012). From a technical point of view, HIFU is feasible and tolerable for non-invasive ablation of deeply located tissue targets.…”