Enhancing photothermal cancer therapy by clustering gold nanoparticles into spherical polymeric nanoconstructs

Iodice, Carmen; Cervadoro, Antonio; Palange, Anna Lisa; Key, Joe L.; Aryal, Santosh; Ramirez, Maricela; Mattu, Clara; Ciardelli, Gianluca; O’Neill, Brian E.; Decuzzi, Paolo

doi:10.1016/j.optlaseng.2015.04.017

Cited by 46 publications

(23 citation statements)

References 20 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gold nanoparticles [e.g., Au NPs and gold nanorods (Au NRs)] have been widely used in cancer research (Wang et al, 2011; Chen et al, 2012; Iodice et al, 2016) by the reason of their facile synthesis, easiness for functionalization, localized surface plasmon resonance, and excellent biocompatibility (Huang and El-Sayed, 2010). In fact, it has been well-established that Au NPs are biocompatible (non-cytotoxic and non-immunogenic), which is very important for the widespread applications in nanomedicine and drug delivery (Ghosh et al, 2008; Brown et al, 2010; Kong et al, 2016).…”

Section: Gold Nanoparticles For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

View full text Add to dashboard Cite

Cancer stem cells (CSCs) have been identified in almost all cancers and give rise to metastases and can also act as a reservoir of cancer cells that may cause a relapse after surgery, radiation, or chemotherapy. Thus they are obvious targets in therapeutic approaches and also a great challenge in cancer treatment. The threat presented by CSCs lies in their unlimited proliferative ability and multidrug resistance. These findings have necessitated an effective novel strategy to target CSCs for cancer treatment. Nanomaterials are on the route to providing novel methods in cancer therapies. Although, there have been a large number of excellent work in the field of targeted cancer therapy, it remains an open question how nanomaterials can meet future demands for targeting and eradicating of CSCs. In this review, we summarized recent and highlighted future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials.

show abstract

Section: Gold Nanoparticles For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Doxorubicin/gold nanoparticles for cancer therapy through the enhanced tumor targeting were experimentally investigated by Kim et al [8]. Lodice et al [9] enhanced photo-thermal cancer therapy by gathering gold nanoparticles in form of nanostructure. Gold nanoparticles have been used in electronics as conductors in printable inks, electronic chips and resistors.…”

Section: Introductionmentioning

confidence: 99%

Impacts of gold nanoparticles on MHD mixed convection Poiseuille flow of nanofluid passing through a porous medium in the presence of thermal radiation, thermal diffusion and chemical reaction

Aman

Khan

Ismail

et al. 2016

Neural Comput & Applic

View full text Add to dashboard Cite

Impacts of gold nanoparticles on MHD Poiseuille flow of nanofluid in a porous medium are studied. Mixed convection is induced due to external pressure gradient and buoyancy force. Additional effects of thermal radiation, chemical reaction and thermal diffusion are also considered. Gold nanoparticles of cylindrical shape are considered in kerosene oil taken as conventional base fluid. However, for comparison, four other types of nanoparticles (silver, copper, alumina and magnetite) are also considered. The problem is modeled in terms of partial differential equations with suitable boundary conditions and then computed by perturbation technique. Exact expressions for velocity and temperature are obtained. Graphical results are mapped in order to tackle the physics of the embedded parameters. This study mainly focuses on gold nanoparticles; however, for the sake of comparison, four other types of nanoparticles namely silver, copper, alumina and magnetite are analyzed for the heat transfer rate. The obtained results show that metals have higher rate of heat transfer than metal oxides. Gold nanoparticles have the highest rate of heat transfer followed by alumina and magnetite. Porosity and magnetic field have opposite effects on velocity.

show abstract

“…The result of the current work showed that GNPs and LGNPs possess spherical shape with small particle size ( 89 nm) that indicated these systems are useful tool as delivery system for chemotherapeutic drugs with ideal tumor accumulation properties (Park et al, 2006;Iodice et al, 2016) and improve the possibility of penetration into the cells in comparison to other formulations (Chithrani et al, 2006). The selected dose of urethane was based on previous work was conducted by (Hamzawy et al, 2015).…”

Section: Histological Examinationsmentioning

confidence: 90%

Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice

et al. 2017

View full text Add to dashboard Cite

The current study aimed to develop gold nanoparticles (GNPs) and liposome-embedded gold nanoparticles (LGNPs) as drug carriers for temozolomide (TMZ) and investigate the possible therapeutic effects of intratracheal inhalation of nanoformulation of TMZ-loaded gold nanoparticles (TGNPs) and liposome-embedded TGNPs (LTGNPs) against urethane-induced lung cancer in BALB/c mice. Physicochemical characters and zeta potential studies for gold nanoparticles (GNPs) and liposome-embedded gold nanoparticles (LGNPs) were performed. The current study was conducted by inducing lung cancer chemically via repeated exposure to urethane in BALB/C mice. GNPs and LGNPs were exhibited in uniform spherical shape with adequate dispersion stability. GNPs and LGNPs showed no significant changes in comparison to control group with high safety profile, while TGNPs and LTGNPs succeed to improve all biochemical data and histological patterns. GNPs and LGNPs are promising drug carriers and succeeded in the delivery of small and efficient dose of temozolomide in treatment lung cancer. Antitumor activity was pronounced in animal-treated LTGNPs, these effects may be due to synergistic effects resulted from combination of temozolomide and gold nanoparticles and liposomes that may improve the drug distribution and penetration.

show abstract

Enhancing photothermal cancer therapy by clustering gold nanoparticles into spherical polymeric nanoconstructs

Cited by 46 publications

References 20 publications

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Impacts of gold nanoparticles on MHD mixed convection Poiseuille flow of nanofluid passing through a porous medium in the presence of thermal radiation, thermal diffusion and chemical reaction

Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice

Contact Info

Product

Resources

About