Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice

Hamzawy, Mohamed A.; Abo-Youssef, Amira M.; Salem, Heba F.; Mohammed, Sameh A.

doi:10.1080/10717544.2016.1247924

Cited by 67 publications

(28 citation statements)

References 59 publications

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“…Urethane-induced lung cancer has been well-characterized and accepted as a model for human lung adenocarcinoma. In lung cancer research, the urethane model of lung cancer has been widely used, particularly in BALB/c mice (37,38). In the present study, BALB/c wild-type (WT) and BALB/c TRAF1 knockout (TRAF1 KO) mice received 7 consecutive weekly i.p.…”

Section: Resultsmentioning

confidence: 99%

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non–Small Cell Lung Carcinogenesis

et al. 2018

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Tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) is a unique TRAF protein that can interact directly or indirectly with multiple TNFR family members, regulatory proteins, kinases, and adaptors that contribute to its diverse functions in specific tissues. However, the role of TRAF1 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we report that TRAF1 is overexpressed in human lung cancer cells and tissues. TRAF1 expression level inversely correlated with patient survival probability. Loss of TRAF1 decelerated tumor invasion in a urethane-induced lung carcinogenesis mouse model. Furthermore, TRAF1 expression affected TRAF2-mediated BRAF Lys48-linked ubiquitination, which was followed by the inhibition of growth and differentiation, and the induction of death in lung cancer cells. Overall, our work suggests that TRAF1 plays a novel role in the regulation of the BRAF/MEK/ERK signaling pathway in NSCLC and offers a candidate molecular target for lung cancer prevention and therapy. These findings identify TRAF1 as a new therapeutic target for NSCLC. .

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Section: Resultsmentioning

confidence: 99%

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non–Small Cell Lung Carcinogenesis

et al. 2018

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“…The results of this in vivo study showed that both TGNPs and LTGNPs have an improved curative effect and low toxicity, and the synergistic effect produced by LTGNPs can improve the properties of the particles. 117 Alalaiwe et al conducted a test in order to evaluate the quantitative oral bioavailability of PEG-coated GNPs in rats by measuring the concentration of gold in the blood, liver, spleen, and kidneys of rats at different time intervals after oral administration of a certain dose of GNPs; 118 however, this classical approach to analyze bioavailability needs more studies. In recent years, hyperthermia and photodynamic therapy have received considerable attention, and numerous studies have shown their great potential for cancer treatment.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

128

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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“…All these properties, together with easy surface functionalisation, make AuNPs versatile platforms for diagnosis, therapy, drug delivery and tissue engineering. Recently, in order to reduce the risk associated with systemic exposure, the use of inhaled AuNPs as drug carrier and radiosensitiser (Hamzawy et al 2017;Hao et al 2015) has been investigated.…”

Section: Introductionmentioning

confidence: 99%

Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

Berardis¹,

Marchetti²,

Risuglia

et al. 2020

J Nanopart Res

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In recent years, the introduction of innovative low-cost and large-scale processes for the synthesis of engineered nanoparticles with at least one dimension less than 100 nm has led to countless useful and extensive applications. In this context, gold nanoparticles stimulated a growing interest, due to their peculiar characteristics such as ease of synthesis, chemical stability and optical properties. This stirred the development of numerous applications especially in the biomedical field. Exposure of manufacturers and consumers to industrial products containing nanoparticles poses a potential risk to human health and the environment. Despite this, the precise mechanisms of nanomaterial toxicity have not yet been fully elucidated. It is well known that the three main routes of exposure to nanomaterials are by inhalation, ingestion and through the skin, with inhalation being the most common route of exposure to NPs in the workplace. To provide a complete picture of the impact of inhaled gold nanoparticles on human health, in this article, we review the current knowledge about the physico-chemical characteristics of this nanomaterial, in the size range of 1–100 nm, and its toxicity for pulmonary structures both in vitro and in vivo. Studies comparing the toxic effect of NPs larger than 100 nm (up to 250 nm) are also discussed.

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Antitumor activity of intratracheal inhalation of temozolomide (TMZ) loaded into gold nanoparticles and/or liposomes against urethane-induced lung cancer in BALB/c mice

Cited by 67 publications

References 59 publications

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non–Small Cell Lung Carcinogenesis

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non–Small Cell Lung Carcinogenesis

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

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