Magnetic Resonance–Guided High-Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation

Chu, William; Staruch, Robert; Pichardo, Samuel; Tillander, Matti; Köhler, Max O.; Huang, Yuexi; Ylihautala, Mika; McGuffin, Merrylee; Czarnota, Gregory J.; Hynynen, Kullervo

doi:10.1016/j.ijrobp.2016.03.019

Cited by 31 publications

(54 citation statements)

References 28 publications

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“…A phase I-IIa clinical trial in patients with colorectal liver metastases showed that HIFU was a safe and effective method for tissue ablation [11]. Results from animal and preclinical studies have found that HIFU induces hyperthermia in rectal targets, which could sensitize tumors to radiation and chemotherapy [12]. Here we found that besides these direct thermal effects, HIFU could also inhibit migration of HCT-116 cells and suppress lung metastasis in a mouse model of colon cancer, suggesting an effect of HIFU in reducing distant metastasis of cancers.…”

Section: Discussionmentioning

confidence: 99%

Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3

Wan

et al. 2019

FEBS Open Bio

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Metastasis is the primary contributor to colorectal cancer mortality. High‐intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence tumor metastasis. Here, we examined the effect of HIFU on tumor metastasis of colorectal cancer cells and the underlying mechanisms. HIFU was observed to inhibit migration of HCT‐116 cells in vitro and suppress lung metastasis in a mouse model of colon cancer. In addition, HIFU up‐regulated microRNA (miR) ‐124 expression, which inhibited the activation of signal transducer and activator of transcription 3 (STAT3) and inhibited migration of HCT‐116 cells. Treatment with an inhibitor of miR‐124 reversed the effect of HIFU on cell migration. In conclusion, our results suggest that HIFU exerts anti‐metastatic effects in colon cancer, and this effect is possibly mediated via up‐regulation of miR‐124 and subsequent miR‐124‐mediated STAT3 suppression.

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Section: Discussionmentioning

confidence: 99%

Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3

Wan

et al. 2019

FEBS Open Bio

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“…HT treatment planning was done using T 2 -weighted MRI [27,30] with the following parameters: echo time ¼ 130 ms, repetition time ¼ 1300 ms, number of signal averages ¼ 1, spatial resolution (in-plane pixel size)¼1.12 Â 1.19 Â 2.5 mm 3 , and flip angle ¼ 90 . MRgHIFU-mediated HT was monitored with MRI thermometry using the proton resonance frequency shift (PRFS) method [26,30,31]. For the temperature monitoring by MR thermometry, a dynamic, RF-spoiled, fast-fieldecho echo-planar imaging (FFE-EPI) sequence was utilized to obtain magnitude and phase images to produce temperature maps.…”

Section: Experimental Designmentioning

confidence: 99%

“…The use of the 44 C threshold was a safety measure allowing for reasonably strict temperature control. It was motivated by the fact that temperatures !45 C have been shown to cause thermal damage within minutes during HT treatments [35] and Chu et al [26] found that when using a maximum temperature threshold of 45 C with the Sonalleve, thermalinduced muscle coagulation occurred.…”

Section: Experimental Designmentioning

confidence: 99%

“…However, performing HT to pelvic targets within a heterogeneous space containing moving organs, moving fluids and a variety of tissues may be technically challenging due to the motion, the inhomogeneity in thermal property of tissues in the pelvic space, the required narrow temperature range and/or the extended duration of HT. Previous studies have demonstrated that a commercial, table-mounted MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) has the ability to uniformly heat deep thigh muscle tissue and the muscle near the rectum in an in vivo porcine model [26,27]. However, these published studies focused only on extremities with limited motion (e.g., thigh muscle) or very specific geometries (e.g., muscle near the lower gastrointestinal tract), neither of which is fully representative of the spectrum of geometrical challenges that might be present in pelvic MRgHIFU treatment.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Zhu

Partanen

Talcott

et al. 2019

International Journal of Hyperthermia

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2019) Feasibility and safety assessment of magnetic resonance-guided highintensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine modelABSTRACT Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided highintensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40-45 C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 C (±1 ) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (T avg ) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 C, the average 30-min T avg variation was 0.80 ± 0.17 C, and the maximum difference between T avg and the 10th-or 90th-percentile temperature averaged 2.01 ± 0.44 C. The average time to reach !41 C and cool to 40 C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. ARTICLE HISTORY

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“…For example, locoregional hyperthermia using phased array systems with one or more rings of antennas surrounding the patient is applied to deep-seated tumours [6][7][8], whereas superficial hyperthermia is applied to tumours up to 4 cm depth from the skin [9][10][11][12][13]. Intraluminal or intracavitary heating can be applied when the tumour is accessible through an existing lumen or cavity [14,15]. Interstitial heating using an implant of small antennas can be combined effectively with brachytherapy (i.e.…”

Section: Introductionmentioning

confidence: 99%

Planning, optimisation and evaluation of hyperthermia treatments

Kok

Kotte

Crezee

2017

International Journal of Hyperthermia

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Background: Hyperthermia treatment planning using dedicated simulations of power and temperature distributions is very useful to assist in hyperthermia applications. This paper describes an advanced treatment planning software package for a wide variety of applications. Methods: The in-house developed Cþþ software package Plan2Heat runs on a Linux operating system. Modules are available to perform electric field and temperature calculations for many heating techniques. The package also contains optimisation routines, post-treatment evaluation tools and a sophisticated thermal model enabling to account for 3D vasculature based on an angiogram or generated artificially using a vessel generation algorithm. The use of the software is illustrated by a simulation of a locoregional hyperthermia treatment for a pancreatic cancer patient and a spherical tumour model heated by interstitial hyperthermia, with detailed 3D vasculature included. Results: The module-based set-up makes the software flexible and easy to use. The first example demonstrates that treatment planning can help to focus the heating to the tumour. After optimisation, the simulated absorbed power in the tumour increased with 50%. The second example demonstrates the impact of accurately modelling discrete vasculature. Blood at body core temperature entering the heated volume causes relatively cold tracks in the heated volume, where the temperature remains below 40 C. Conclusions: A flexible software package for hyperthermia treatment planning has been developed, which can be very useful in many hyperthermia applications. The object-oriented structure of the source code allows relatively easy extension of the software package with additional tools when necessary for future applications.

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Magnetic Resonance–Guided High-Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation

Cited by 31 publications

References 28 publications

Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3

Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3

Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Planning, optimisation and evaluation of hyperthermia treatments

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