Magnetic resonance contrast media (review)

Сергеев, П. В.; Шимановский, Н. Л.; Панов, В. О.

doi:10.1007/bf00758284

Cited by 2 publications

(8 citation statements)

References 48 publications

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“…The chelate effect of XRCM towards serum free Ca 2+ should be observed in humans and animals. For example, it affects anticoagulant activity of XRCM [8]. However, our results and literature data indicate that strong coordinate binding of Ca 2+ by an XRCM molecule cannot be responsible for a decrease in serum free Ca 2+.…”

Section: Resultscontrasting

confidence: 76%

“…Previously, we demonstrated both necessity and feasibility of dividing animals into a "sensitive" group a CM-induced decrease in serum Ca 2+, and a "tolerant" group without variations in serum Ca 2+ under the same conditions [8]. Table 1 shows the data on "sensitive" rats.…”

Section: Resultsmentioning

confidence: 96%

“…All these effects of XRCM depend on free Ca 2+ entry from blood into the cytoplasm or on its binding by the proteins of the complement system in the vascular bed, which finally leads to a decrease in free Ca 2+. The nonionic agents melitrast, omnipaque, and ultravist have the large side radicals of the benzene rings that determine their biological inertness in comparison with ionic XRCM [8]. They are less effective in provoking pathological processes that involve extracellular calcium.…”

Section: Resultsmentioning

confidence: 98%

“…Using other biochemical and cytological reactions induced by XRCM, we demonstrated individual sensitivity of humans and animals to CM, and ordered them according to Ca2+-lowering activity: nonionic XRCM<ionic monomeric and dimeric XRCM with bulk side radicals, low viscosity and low osmolality<monomeric ionic XRCM<di-meric ionic XRCM. XRCM cause the release of histamine from mast cells and basophilic leukocytes, increase the titer of blood eicosanoids, induce platelet aggregation, activate the complement system, inhibit the ADP activity of cell membranes, decrease the vascular tone, and produce antithyroid and mitogenetic effects on blood monocytes [6,8,10,13,14]. All these effects of XRCM depend on free Ca 2+ entry from blood into the cytoplasm or on its binding by the proteins of the complement system in the vascular bed, which finally leads to a decrease in free Ca 2+.…”

Section: Resultsmentioning

confidence: 99%

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Effect of contrast media on free calcium concentration in rat bloodin vivo

et al. 1998

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The X-ray contrast media omnipaque=melitrast=ultravist _7). The experimental rats were injected intravenously with warmed (37~ CM in the doses corresponding to those used in clinics. The controls were injected with isoosmotic physiological saline under the same conditions. The infusion rate was 0.1 ml/sec. After 15 rain the rats were decapitated under weak ether anesthesia. Serum was obtained by sedimentation of the blood at 4~ followed by a 8-rain centrifugation (400g, 4~ Serum Ca 2+ concentration was determined spectrophotometrically

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Section: Resultscontrasting

confidence: 76%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Effect of contrast media on free calcium concentration in rat bloodin vivo

et al. 1998

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“…Most of side effects produced by contrast media are due to degranulation of mast ceils and basophilic leukocytes with the release of histamine and other biologically active substances into extracellular fluids [3,7,11]. Free histamine appearing in tissue fluids and blood after administration of a contrast medium contributes to various adverse reactions such as itching eruption, erythema, urticaria, and spasms and edemas of the airways and lungs [3].…”

Section: Abstract: X-ray Contrast Media; Histamine; Calciummentioning

confidence: 99%

Mechanisms of histamine-releasing action of X-ray contrast media

1996

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It is demonstrated in vitro that X-ray contrast media cause the release of histamine from rabbit basophilic leukocytes in a dose-dependent manner at 37~ They are arranged in the following order of decreasing ability to induce the release of histamine: bilignost-triombrast>peritrast~ultravist>melitrast-omnipaque. The extent to which basophils in whole blood are degranulated during incubation with any of these media is about 40% higher than that upon incubation of isolated leukocytes with these media. The release of histamine under the action of the contrast media is a Ca>-dependent process. Key Words: X-ray contrast media; histamine; calciumMost of side effects produced by contrast media are due to degranulation of mast ceils and basophilic leukocytes with the release of histamine and other biologically active substances into extracellular fluids [3,7,11]. Free histamine appearing in tissue fluids and blood after administration of a contrast medium contributes to various adverse reactions such as itching eruption, erythema, urticaria, and spasms and edemas of the airways and lungs [3]. However, the mechanisms of these reactions have not been elucidated, and the role of Ca ~- § is unclear, although calcium is the key second messenger in the transmission of specific transmembrane signals [8].This study was designed to find out how the histamine-releasing activity of contrast media depends on their structure and to evaluate the significance of Ca>in this activity. MATERIALS AND METHODSThe ionic contrast media bilignost and triombrast (manufactured at the Lomonosov Chemical-PharmaDepartment of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow ceutical Factory, Ukraine) and peritrast (Dr. Kohler Chemic) and the nonionic media omnipaque (Nycomed), melitrast (Dr. Kohler Chemic), and ultravist (Schering) were incubated for 30 min at room temperature with whole blood or leukocyte suspension at final concentrations of 0.03, 0.3, 3, and 30 mg iodine/mI (mg I/ml). In control tests, the same volumes of isotonic physiological solution were added to the samples.Basophilic leukocytes were isolated and counted by the standard procedure [12]. Heparin (0.1 ml, 1000 U/ml), dextran glucose (2 ml), and peripheral venous blood (10 ml) were thoroughly mixed in a 20 ml syringe. Erythrocytes were sedimented in a vertically positioned syringe for 50 min at room temperature. Leukocytes from the decanted plasma layer were obtained by centrifugation at 150g for 8 min. The cells were washed twice with cold Trisalbumin buffer (150g, 8 min) and resuspended in Tris-AMS buffer. Basophils were counted in suspension under a light microscope after staining with 0.1% neutral red in ethanol (v/v,=l/50). Basophil count in a sample incubated with contrast medium was equal to that in whole blood. These procedures were carried out at 4~

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Magnetic resonance contrast media (review)

Cited by 2 publications

References 48 publications

Effect of contrast media on free calcium concentration in rat bloodin vivo

Effect of contrast media on free calcium concentration in rat bloodin vivo

Mechanisms of histamine-releasing action of X-ray contrast media

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