Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin

Орел, В.Е.; Shevchenko, A. V.; Romanov, A. V.; Tselepi, M.; Mitrelias, T.; Barnes, C. H. W.; Burlaka, Anatoliy; Lukin, S. M.; Shchepotin, I.

doi:10.1016/j.nano.2014.07.007

Cited by 91 publications

(54 citation statements)

References 24 publications

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“…1 shows depletion of ROS at lower concentrations and ROS bursts at higher concentrations. This might be the indication that CoFe 2 O 4 NBs at lower concentration initiates the uncontrolled proliferation of cells and at higher concentrations lead to apoptosis or necrosis (Orel et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

2015

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Section: Discussionmentioning

confidence: 99%

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

2015

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“…However, there is a number of magnetic nanotherapy limitations such as: risk is the probability of a specific adverse effect if nanoparticles are accumulated in organs; aggregation of ferromagnetic nanoparticles due to remanent magnetization can damage the blood circulation in normal tissues; the need for individual selection of the magnetic properties of antitumor nanocomplexes for various tumors . …”

Section: Introductionmentioning

confidence: 99%

Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis Lung carcinoma

Орел

Romanov

Rykhalskyi

et al. 2016

Materialwissenschaft Werkst

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Superparamagnetic Iron(II,III) oxide Fe 3 O 4 nanoparticles (NP) in magnetic nanocomplex (MNC2) with antitumor drug doxorubicin (DOXO) induced a greater antitumor and antimetastatic effect compared to the magnetic nanocomplex (MNC1) composed of ferromagnetic nanoparticles with DOXO and conventional DOXO during magnetic nanotherapy of animals with Lewis lung carcinoma. The intratumor temperature did not exceed 39°C. MNC2 had g-factors of 2.00, 2.30 and 4.00. MNC1 had the g-factor of 2.50. The MNC2 increased the content of Nitric oxide -Iron(II) sulfide protein N complex and NADH-ubiquinone in tumor as compared to MNC1 or conventional DOXO. The results have been analyzed in terms of increased level of reactive oxygen species which could induce death of tumor cells.

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“…The applications of Nanomedicines have been far and widespread [1,2]. From the development of diagnostic devices [3], analytical tools [4], physical therapy applications [3,5] to therapeutic drug delivery [4][5][6], and targeted drug delivery [5].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Study of Silver Nanoparticle Coupled with Euphorbia thymifolia

Saha¹,

Bala²,

Basu³

et al. 2018

JNST

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Nanomedicine is widely explored nowadays for treatment of life threatening diseases, yet comes with various challenges and questions. The present study encapsulates the acute toxicological aspects of the Euphorbia thymifolia coupled silver nanoparticles (ET-Ag NP). For acute toxicity studies according to OCED (Organization for Economic Cooperation Development) guidelines Swiss Albino mice (6-8 weeks) were used and were given single intraperitoneal dose of 2000 and 5000 mg/kg body weight and were observed for mortality and other side effects for 14 days. The individual components of the formulation, viz. silver oxide in surface modified nano form and at low dose, and Euphorbia thymifolia are both biocompatible materials. No changes were found for general appearance, behavior and body weight, thus concluding that the nanocomposite formulation does not have single dose toxicity.

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Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin

Cited by 91 publications

References 24 publications

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: Interaction, adaptation and oxidative stress

Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis Lung carcinoma

Acute Toxicity Study of Silver Nanoparticle Coupled with Euphorbia thymifolia

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