Magnetic Properties and Antibacterial Activity of Tetranuclear Copper Complexes Bridged by Oxo Group

Abstract

A series of three tetranuclear Cu(II) complexes of general formula [Cu 4 OCl 6 L 4 ], where L is a Lewis Base ligand has been characterized through magnetic measurements and determination of antimicrobial activities. This study include the following species [Cu 4 OCl 6)Cl(PhIm) 3 ](HPhIm)•H 2 O (1) where PhIm= 4-phenylimidazole, [(Cu 4 OCl 6)(PyNO) 4 ]• 1 / 5 (H 2 O) (2) where PyNO= Pyridine-N-oxide and [(Cu 4 OCl 6)(MeIm) 4 ]•3(CH 3 OH) (3) where MeIm = 2-methylimidazole. The polynuclear cluster in the complexes contains a central oxygen atom tetrahedral coordinated to four copper(II) ions, each of which coordinates a monodentate L ligand. Each pair of copper atoms is bridged by on a chlorine ion, resulting a trigonal bipiramidal environment. The variable temperature magnetic susceptibilities of these complexes were investigated in the temperature range 5-300K. Satisfactory fits to the observed susceptibility data were obtained only for the complexes (1) and (3), by assuming isotropic magnetic exchange interactions and using the appropriate spin Hamiltonian and susceptibility equation giving the coupling constants J 1 = 0.148cm-1 , J 2 =-1.707 cm-1 for (1) and J 1 = 0.522 cm-1 , J 2 =-5.32 cm-1 for (3). The antimicrobial activities of these complexes have been screened in vitro against Gram positive and negative bacteria.

Cytotoxic copper(II), cobalt(II), zinc(II), and nickel(II) coordination compounds of clotrimazole

“…The corresponding bond distances for each bromide and its Cu II atom differ from each subunit; the lengths range from 2.4683(9) Å for Cu(1)\Br(3) to 2.5615(9) for Cu(2)\Br(4) ( Table 2B). Few isostructural complexes to 5a have been reported before [28,29] and they belong to a particular set of systems namely the [Cu 4 X 6 OL 4 ] complexes, where L denotes any Lewis base ligand and X is an halogen such as chloride or bromide.…”

X-Ray Studies and Antibacterial Activity in Copper and Cobalt Complexes With Imidazole Derivative Ligands

“…[7][8][9][10][11][12] There are numerous copper(II) compounds that present biological activity as antiinflammatory, anticonvulsive, antifungal, antibacterial, and antimicrobial agents. [13][14][15][16][17][18] An example is the trans-bis(acetate)bis(imidazole)copper(II) complex, which exhibits the strongest antitumor activity against the mouse melanoma cancer cell line B16. 19 Cobalt(II) complexes with N6-substituted adenine derivatives have also been suggested as efficient drugs against human malignant melanoma tumour (G361) osteogenic sarcoma (HOS).…”

Magnetic Behavior and Antibacterial Activity of Iron (Iii) Complexes

“…We note that in both cases the Fe atoms placed in the triangular array. In the complex The magnetic properties on the title complex differ greatly in relation to complex (3), in this case the exchange constant is J= -2,71cm -1 .…”

“…Some metals are essential for biological function and are found in enzymes and cofactors required for various processes. Transition metals also plays a role as drugs to treat of variety of diseases and conditions [1][2][3] .…”