Magnetic polymer particles modified with β-cyclodextrin

Ghorbani, Zahra; Baharvand, Habibollah; Nezhati, Mahshid Nikpour; Panahi, Homayon Ahmad

doi:10.1007/s10965-013-0199-0

J Polym Res

2013

DOI: 10.1007/s10965-013-0199-0

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Magnetic polymer particles modified with β-cyclodextrin

Zahra Ghorbani

Habibollah Baharvand

Mahshid Nikpour Nezhati

et al.

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Cited by 5 publications

(1 citation statement)

References 30 publications

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“…While this step was beyond the scope of this protocol, several modern techniques can be applied to investigate the efficiency of chemical modifications. 11,12,13,14 Fourier transform infrared spectroscopy (FTIR) can be used to evaluate the infrared spectrum of particle surface and compare it to the spectrum of free chemical modifiers. X-ray photoelectron spectroscopy (XPS) is another technique that can be used to identify the elemental composition of material surface.…”

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confidence: 99%

DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering

Haddad¹,

Dostálová²,

Kudr³

et al. 2017

JoVE

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Isolation of DNA using magnetic particles is a field of high importance in biotechnology and molecular biology research. This protocol describes the evaluation of DNA-magnetic particles binding via dynamic light scattering (DLS) and electrophoretic light scattering (ELS). Analysis by DLS provides valuable information on the physicochemical properties of particles including particle size, polydispersity, and zeta potential. The latter describes the surface charge of the particle which plays major role in electrostatic binding of materials such as DNA. Here, a comparative analysis exploits three chemical modifications of nanoparticles and microparticles and their effects on DNA binding and elution. Chemical modifications by branched polyethylenimine, tetraethyl orthosilicate and (3-aminopropyl)triethoxysilane are investigated. Since DNA exhibits a negative charge, it is expected that zeta potential of particle surface will decrease upon binding of DNA. Forming of clusters should also affect particle size. In order to investigate the efficiency of these particles in isolation and elution of DNA, the particles are mixed with DNA in low pH (~6), high ionic strength and dehydration environment. Particles are washed on magnet and then DNA is eluted by Tris-HCl buffer (pH = 8). DNA copy number is estimated using quantitative polymerase chain reaction (PCR). Zeta potential, particle size, polydispersity and quantitative PCR data are evaluated and compared. DLS is an insightful and supporting method of analysis that adds a new perspective to the process of screening of particles for DNA isolation.

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mentioning

confidence: 99%

DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering

Haddad¹,

Dostálová²,

Kudr³

et al. 2017

JoVE

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Synthesis of functionalized magnetic nanoparticles as a nanocarrier for targeted drug delivery

2018

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In this research, iron oxide magnetic nanoparticles (NPs) were synthesized by chemical co‐precipitation method. The surface of particles was grafted with β‐cyclodextrin/N,N‐dimethylacrylamide (β‐CD/DMAA) copolymer. Potency of NPs as carrier of antibiotic ofloxacin (OFL) was evaluated. They were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The effect of the adsorption parameters such as pH, contact time, and temperature for sorption of drug onto NPs was evaluated and optimized. The drug release profile showed that approximately 60% of the adsorbed drug was released in the first 10 min at pH of 1.2 (simulated gastric fluid) and 55% was released within 30 hr in pH of 7.4 (simulated intestinal fluid). Findings of study suggested the suitability of β‐CD/DMAA grafted magnetic NPs for OFL delivery.

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Structure and sorption properties of hypercrosslinked polystyrenes and magnetic nanocomposite materials based on them

et al. 2014

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Magnetic polymer particles modified with β-cyclodextrin

Cited by 5 publications

References 30 publications

DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering

DNA-magnetic Particle Binding Analysis by Dynamic and Electrophoretic Light Scattering

Synthesis of functionalized magnetic nanoparticles as a nanocarrier for targeted drug delivery

Structure and sorption properties of hypercrosslinked polystyrenes and magnetic nanocomposite materials based on them

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