Cisplatin is a chemotherapeutic agent used for treating various malignancies. The study aimed to prepare pegylated liposomal cisplatin and evaluate its efficacy against human breast cancer cell line MCF-7. Drug-loaded nanoparticles were synthesized by reverse phase evaporation technique. The study is highlighted by extensive characterization of nanoparticles in terms of nanoparticle morphology, type of drug entrapment, cisplatin retention capability, and cytotoxicity effects. The size, size distribution, and zeta potential of nanodrug were estimated 142 nm, 0.33, and -22 mV, respectively. Drug-loading efficiency was equal to 48% that occurred physically. Furthermore, high retention capability (39% of drug was released after 72 h) with significantly enhanced cytotoxicity of nanodrug (1.75 times more than the standard drug) confirmed the potency of liposomal nanoparticles as proper cisplatin carrier.
In this research, iron oxide magnetic nanoparticles (NPs) were synthesized by chemical co‐precipitation method. The surface of particles was grafted with β‐cyclodextrin/N,N‐dimethylacrylamide (β‐CD/DMAA) copolymer. Potency of NPs as carrier of antibiotic ofloxacin (OFL) was evaluated. They were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The effect of the adsorption parameters such as pH, contact time, and temperature for sorption of drug onto NPs was evaluated and optimized. The drug release profile showed that approximately 60% of the adsorbed drug was released in the first 10 min at pH of 1.2 (simulated gastric fluid) and 55% was released within 30 hr in pH of 7.4 (simulated intestinal fluid). Findings of study suggested the suitability of β‐CD/DMAA grafted magnetic NPs for OFL delivery.
Chemotherapy is one of the main treatment regimens for cancer therapy. Efficacy of chemotherapy is limited issues such as nonspecific cytotoxicity, poor aqueous solubility, and bioavailability. Targeted drug delivery is an ideal strategy to overcome these barriers. Fe3O4 magnetic nanoparticles (MNPs) as a great drug delivery system have drawn considerable attention. Functionalized nanoparticles (NPs) here were synthesized by the coprecipitation method and characterized by thermogravimetric analysis and transmission electron microscopy techniques. An anticancer agent, doxorubicin (DOX), was loaded onto the NPs and then the release behavior and cytotoxicity effects of nanodrug were determined. The pH‐sensitive behavior of drug release was observed. While the total loaded drug was released at pH 1.2 in 30 min, the amount of drug release was equal to 8% in pH 7 after 8 h. The drug‐loading efficiency was found to be 88%. Also, NPs potentiate the efficacy of the drug by increasing its cytotoxicity, in which IC50 of 57 and 39 μM for the nanodrug and drug was estimated, respectively. In conclusion, the results of the study showed that MNPs are promising vehicle for DOX delivery.
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