Magnetic poly(glycidyl methacrylate) microspheres prepared by dispersion polymerization in the presence of electrostatically stabilized ferrofluids

Abstract

Fine magnetite nanoparticles, both electrostatically stabilized and nonstabilized, were synthesized in situ by precipitation of Fe(II) and Fe(III) salts in alkaline medium. Magnetic poly(glycidyl methacrylate) (PGMA) microspheres with core‐shell structure, where Fe3O4 is the magnetic core and PGMA is the shell, were obtained by dispersion polymerization initiated with 2,2′‐azobisisobutyronitrile (AIBN), 4,4′‐azobis(4‐cyanovaleric acid) (ACVA), or ammonium persulfate (APS) in ethanol containing poly(vinylpyrrolidone) or ethylcellulose stabilizer in the presence of iron oxide ferrofluid. The average microsphere size ranged from 100 nm to 2 μm. The effects of the nature of ferrofluid, polymerization temperature, monomer, initiator, and stabilizer concentration on the PGMA particle size and polydispersity were studied. The particles contained 2–24 wt % of iron. AIBN produced larger microspheres than APS or ACVA. Polymers encapsulating electrostatically stabilized iron oxide particles contained lower amounts of oxirane groups compared with those obtained with untreated ferrofluid. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 5827–5837, 2004

Synthesis and characterization of magnetic poly(glycidyl methacrylate) microspheres

“…The surfactants often used to stabilize magnetic nanoparticles are based on hexadecyltrimethylammonium bromide or anionic sodium dodecylbenzenesulfonate. As it was found in our previous study that the anionic Fe 3 O 4 was found to be superior to the cationic one in terms of a higher amount of iron oxide incorporated in the product [13], a negative charge was introduced onto the particle surface by TMAH also in this study. Fig.…”

Concanavalin A immobilized magnetic poly(glycidyl methacrylate) beads for prostate specific antigen binding

“…The mPGMA beads were synthesized by dispersion polymerization in a magnetically driven, sealed polymerization reactor equipped with a temperature control system [15,16] as reported elsewhere [17]. Fe 3 O 4 (0.05 g) nanoparticles were dispersed in 68 g of aqueous ethanol solution (96%) by sonication for 30 min at 200 W in an ultrasonic water bath (Sonorex Super 10 P, Bandelin, Germany).…”

Controllable preparation of magnetic polymer microspheres with different morphologies by miniemulsion polymerization

“…Mostly, Fe 3 O 4 has been used as the magnetic core and polymers such as polystyrene [14], poly(glycidyl methacrylate) [15], and polyvinyl alcohol [16] have been used as the shells. Recently, micro-or miniemulsion polymerization has been widely used due to its easiness to obtain surface-functionalized microspheres with uniform particle dispersion.…”