Magnetic PECA nanoparticles as drug carriers for targeted delivery: Synthesis and release characteristics

Abstract

Magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs (Cisplatin and Gemcitabine) were prepared by inter-facial polymerization. The spherical nanoparticles (d = 250 +/- 15 nm) with smooth surfaces and moderately uniform size distributions were obtained. The amount of magnetite encapsulated inside the polymer matrix was increased up to 14.26% (w/w) by controlling the initial weight ratio of monomer/magnetite. It was found that the amount of Cisplatin encapsulated in the magnetic nanoparticle is much higher than that of Gemcitabine because Cisplatin (hydrophobic) is highly soluble in the oil phase and encapsulated easier inside nanoparticles compared to Gemcitabine (hydrophilic). The presence of magnetite and its super-paramagnetic characteristic were confirmed by FTIR spectra and VSM. In-vitro experiments of drug release and magnetic mobility under external magnetic field demonstrated that magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles can be a highly versatile magnetic drug carrier with sustained release behaviour and sufficient magnetic susceptibility.

Preparation of albumin nanospheres loaded with gemcitabine and their cytotoxicity against BXPC-3 cells in vitro

“…The time for slow release of GEM from GEM-NSPs observed in this study was not longer than 12 h, probably because of GEM high water solubility, as reported previously [13][14][15][16][17][18][19] . However, since pure GEM is rapidly metabolized, prolongation of the release time of GEM by GEM-NSPs represents an improvement.…”

“…Drug loadings were 11.25% and 13.40%; drug encapsulation rates were 82.92% and 92.56%, respectively. These parameters were somewhat higher than in other kinds of drug-loaded nanoparticles prepared analogously [13][14][15][16][17][18][19] . Zeta potentials were -24.4 and -15.6 mV, respec- Figure 1).…”

“…Albumin is a safe, nontoxic, biocompatible, and biodegradable water-soluble protein present in human plasma [10][11][12] . No problems with hemolysis or immunogenicity have been associated with albumin, in contrast to artificial npg materials such as polycaprolactone, polycyanoacrylate, or polybutylcyanoacrylate [13][14][15][16][17][18][19] . Although these compounds are also biodegradable, their safety following intravenous injection has not been confirmed.…”

Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

“…The different in situ polymerization methods that have been used to prepare drug delivery systems include interfacial polymerization (23)(24)(25), free radical polymerization (26,27), anionic polymerization (28), ring-opening polymerization (29), frontal polymerization (30), micellar copolymerization, and network polymerization (31).…”

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

“…In an in vitro study, magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs were shown to release drug and have magnetic mobility under external magnetic field (Yang et al, 2006). Intra-caroid administration of polyethyleneimine (PEI) modified magnetic nanoparticles in conjunction with magnetic targeting resulted in 30 fold increase in tumor entrapment of particles compared to that seen with intravenous administration (Chertok et al, 2010).…”