Magnetic Particle Spectroscopy-Based Handheld Device for Wash-Free, Easy-to-Use, and Solution-Phase Immunoassay Applications

Chugh, Vinit Kumar; Wu, Kai; Nair, Abilash; Girolamo, Arturo Di; Schealler, James; Vuong, Hoang Van; Davies, W. L.; Wall, Adam; Whitely, Emmet; Saha, Renata; Su, Diqing; Wang, Jian Ping

doi:10.1115/dmd2020-9054

Cited by 3 publications

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“…It is powered by wall plug and can communicate with smartphones (Android and IOS systems), tablets, computers through Bluetooth and USB. 38 The device shell (Figure 1a-i) is 3D printed with a polylactic acid (PLA) material. The biofluid sample holder is a flat bottom, USP type I, glass vial with dimensions of 31 mm × 5 mm and a volume capacity of 0.25 mL (Figure 1a-ii).…”

Section: Methodsmentioning

confidence: 99%

“…The overall dimensions of this device are 212 mm (L) × 84 mm (W) × 72 mm (H). It is powered by wall plug and can communicate with smartphones (Android and IOS systems), tablets, computers through Bluetooth and USB . The device shell (Figure a-i) is 3D printed with a polylactic acid (PLA) material.…”

Section: Experimental Sectionmentioning

confidence: 99%

“…It is powered by wall-plug and can communicate with smartphones (Android and IOS systems), tablets, computers through Bluetooth and USB. 37 The device shell (Figure 1 Discrete time voltage signal collected from pick-up coils during two periods of low frequency field. The dynamic magnetic responses of MNPs cause visible spikes as highlighted in grey regions.…”

Section: Introductionmentioning

confidence: 99%

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A Portable Magnetic Particle Spectrometer for Future Rapid and Wash-Free Bioassays

Chugh

Girolamo

et al. 2021

ACS Appl. Mater. Interfaces

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Nowadays, there is an increasing demand for more accessible routine diagnostics for patients with respect to high accuracy, ease of use, and low cost. However, the quantitative and high accuracy bioassays in large hospitals and laboratories usually require trained technicians and equipment that is both bulky and expensive.In addition, the multi-step bioassays and long turnaround time could severely affect the disease surveillance and control especially in pandemics such as influenza and COVID-19. In view of this, a portable, quantitative bioassay device will be valuable in regions with scarce medical resources and help relieve burden on local healthcare systems. Herein, we introduce the MagiCoil diagnostic device, an inexpensive, portable, quantitative and rapid bioassay platform based on magnetic particle spectrometer (MPS) technique. MPS detects the dynamic magnetic responses of magnetic nanoparticles (MNPs) and uses the harmonics from oscillating MNPs as metrics for sensitive and quantitative bioassays. This device does not require trained technicians to operate and employs a fully automatic, one-step, wash-free assay with user friendly smartphone interface. Using a streptavidin-biotin binding system as a model, we show that the detection limit of the current portable device for streptavidin is 64 nM (equal to 5.12 pmole). In addition, this MPS technique is very versatile and allows for the detection of different diseases just by changing the surface modifications on MNPs. It's foreseen that this kind of portable device can transform the multi-step, laboratory-based bioassays to one-step field testing in non-clinical settings such as schools, homes, offices, etc.

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Section: Methodsmentioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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