Magnetic particle imaging for aerosol-based magnetic targeting

Banura, Natsuo; Murase, Kenya

doi:10.7567/jjap.56.088001

Cited by 7 publications

(8 citation statements)

References 15 publications

(25 reference statements)

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“…Both MRI and MPI can benefit from these targeting strategies to enhance the concentration of imaging agent in a region-of-interest for increased binding probability to targets resulting in better imaging or localization of dose for better therapy. For example, Dames et al 2007 demonstrated the use of a shaped magnetic tip for targeted delivery of magnetic aerosol droplets to the lung [ 14 ] ( Figure 1 e) and Banura et al 2017 conducted a similar study with the addition of MPI to image the final biodistribution in the lungs after targeting [ 13 ] ( Figure 6 a). Other than the lungs, permanent magnets have been used to enhance delivery to tumors in other parts of the body.…”

Section: Magnetic-based Steering and Targeting Strategies Using Mpi Hardwarementioning

confidence: 99%

“…( c ) Yu et al 2017 [ 12 ]—MPI image of SPIONs accumulated within a tumor. ( d ) Banura et al 2017 [ 13 ]—magnetic steering of magneto-aerosol with MPI as post-event verification. ( e ) Dames et al 2007 [ 14 ]—magnetic tip for targeted delivery of magnetic aerosol to lung.…”

Section: Figurementioning

confidence: 99%

“…J. Appl. Phys 2017 [ 13 ] under Creative Commons 4.0. ( a ) Magnetic steering of aerosolized magnetic nanoparticles to deposit in a user-selected side of a lung imaging phantom.…”

Section: Figurementioning

confidence: 99%

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Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.

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Section: Magnetic-based Steering and Targeting Strategies Using Mpi Hardwarementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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“…This enabled localized treatment of tumors (potentially lung tumors) while sparing other tissues with non-specific SPION uptake 47 , 50 . Furthermore, because SPIONs can be shifted by magnetomotive forces from magnetic gradient fields, the therapeutic aerosol can be additionally moved in an image-guided fashion to a target region of the lung, increasing therapeutic efficiency 43 , 74 .…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, MPI is fully quantitative with zero depth attenuation as validated in prior work 22 , 30 thus is able to quantify the inhaled aerosol at any depth and with no view limitations since the low frequency magnetic excitation fields used in MPI penetrate completely through all types of tissue. Magnetic particle imaging has also been studied in many other applications (preclinical models) such as real-time MPI-guidance of catheters 40 , 41 , stroke diagnosis 35 , angiography 42 , lung perfusion 19 , lung ventilation 20 , 43 , cancer imaging 44 , stem cell tracking 8 , 18 , 45 , brain perfusion imaging 46 , magnetic hyperthermia 47 - 50 and gut bleed detection 51 .…”

Section: Introductionmentioning

confidence: 99%

In vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring

et al. 2018

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Pulmonary delivery of therapeutics is attractive due to rapid absorption and non-invasiveness but it is challenging to monitor and quantify the delivered aerosol or powder. Currently, single-photon emission computed tomography (SPECT) is used but requires inhalation of radioactive labels that typically have to be synthesized and attached by hot chemistry techniques just prior to every scan.Methods: In this work, we demonstrate that superparamagnetic iron oxide nanoparticles (SPIONs) can be used to label and track aerosols in vivo with high sensitivity using an emerging medical imaging technique known as magnetic particle imaging (MPI). We perform proof-of-concept experiments with SPIONs for various lung applications such as evaluation of efficiency and uniformity of aerosol delivery, tracking of the initial aerosolized therapeutic deposition in vivo, and finally, sensitive visualization of the entire mucociliary clearance pathway from the lung up to the epiglottis and down the gastrointestinal tract to be excreted.Results: Imaging of SPIONs in the lung has previously been limited by difficulty of lung imaging with magnetic resonance imaging (MRI). In our results, MPI enabled SPION lung imaging with high sensitivity, and a key implication is the potential combination with magnetic actuation or hyperthermia for MPI-guided therapy in the lung with SPIONs.Conclusion: This work shows how magnetic particle imaging can be enabling for new imaging and therapeutic applications of SPIONs in the lung.

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Shape Anisotropy‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

Nigam,

Mohapatra,

Makela

et al. 2023

Small

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Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal‐to‐noise ratios to lung imaging for the development of new theranostic approaches for respiratory diseases. Advances in MPI tracers would offer additional improvements and increase the potential for clinical translation of MPI. Here, a high‐performance nanotracer based on shape anisotropy of magnetic nanoparticles is developed and its use in MPI imaging of the lung is demonstrated. Shape anisotropy proves to be a critical parameter for increasing signal intensity and resolution and exceeding those properties of conventional spherical nanoparticles. The 0D nanoparticles exhibit a 2‐fold increase, while the 1D nanorods have a > 5‐fold increase in signal intensity when compared to VivoTrax. Newly designed 1D nanorods displayed high signal intensities and excellent resolution in lung images. A spatiotemporal lung imaging study in mice revealed that this tracer offers new opportunities for monitoring disease and guiding intervention.

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Magnetic particle imaging for aerosol-based magnetic targeting

Cited by 7 publications

References 15 publications

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

In vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring

Shape Anisotropy‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

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