Shape Anisotropy‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

Abstract

Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal‐to‐noise ratios to lung imaging for the development of new theranostic approaches for respiratory diseases. Advances in MPI tracers would offer additional improvements and increase the potential for clinical translation of MPI. Here, a high‐performance nanotracer based on shape anisotropy of magnetic nanoparticles is developed and its use in MPI imaging of the lung is demonstrated. Shape anisotropy proves to be a critical parameter for increasing signal intensity and resolution and exceeding those properties of conventional spherical nanoparticles. The 0D nanoparticles exhibit a 2‐fold increase, while the 1D nanorods have a > 5‐fold increase in signal intensity when compared to VivoTrax. Newly designed 1D nanorods displayed high signal intensities and excellent resolution in lung images. A spatiotemporal lung imaging study in mice revealed that this tracer offers new opportunities for monitoring disease and guiding intervention.

Post-synthesis Oxidation of Superparamagnetic Iron Oxide Nanoparticles to Enhance Magnetic Particle Imaging Performance

“…However, they studied a single sample representative of each condition, and the four studied samples had a narrow range in shape. Another suggested that shape anisotropy of ∼50 nm long and ∼8 nm wide nanorods improves their MPI performance . However, this study provided very limited physical and magnetic characterization of the nanoparticles used, and the claim is based on comparison between ∼50 nm long nanorods and ∼13 nm spherical nanoparticles.…”

Magnetic and electronic properties of anisotropic magnetite nanoparticles

“…Recently, we explored oleylamine as a multi-functionalizing agent to synthesize nanoparticles with controlled shapes and desired stoichiometry. Figure 8 shows Fe 3 O 4 nanoparticles of different shapes synthesized via the thermal decomposition of iron (III) acetylacetonate and the chemical reduction of FeOOH nanorods using oleylamine as solvent and surfactant [75,112,113].…”

The Application of Nanovaccines in Autoimmune Diseases

“…Iron oxide nanoparticles, which have unique magnetic properties, exhibit outstanding performance and significant potential for use in biomedical applications, such as magnetic resonance imaging and targeted drug delivery. 33 As a delivery system, iron oxide nanoparticles can transport antigens to the immune system or serve as immune adjuvants to enhance antigen processing. To prevent the aggregation and oxidation of magnetic nanoparticles after synthesis, these nanoparticles can be coated with single-layer ligands, polymers, combinations of polymers and biomolecules (phospholipids and carbohydrates), or inorganic materials (silica and gold).…”