Magnetic, Optical and Biological Studies on Copper(II) Complexes with 2-benzothiazolyl Hydrazones. II

Abstract

Three Cu(II) complex compounds with 4-methoxybenzaldehyde-2-benzothiazolyl hydrazone (HL) have been prepared and characterized by elemental and thermogravimetrical analysis, infrared, electronic and EPR spectra. The complex compounds have various composition and stereochemistry, depending on the reaction conditions and the metal salt used. The ligand acts as neutral bidentate NN donor in the complexes [Cu(HL) 2 (H 2 O) 2 ] . Cl 2 and [Cu(HL) 2 (H 2 O)Br] . Br and monobasic bidentate donor in the complex [Cu 2 L 4 ].EPR studies of the complexes gave axial symmetry, with d x2-y2 the ground state. The bonding parameters calculated from the electronic and EPR spectra indicate strong in-plane π-bonding for all the complexes. Investigations on antibacterial and antifungal activities show that the complexes are more active than the free ligand.

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…The purpose was to determine the form of coordination of these ligands and their influence on biological activity. The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz- 16 The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140].…”

“…The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz- 16 The authors reported different copper complexes with bidentate and tridentate ligands as in Btz-16, Btz-22-Btz-24 [138], Btz-17a, Btz-17b, Btz-20 [139], and even using mixed ligands as in Btz-18, Btz-19, Btz-25 [140]. The complexes presented different distorted geometries; for example, Btz The authors mention that it is possibly due to the more rapid diffusion of these metal complexes through the cell membrane.…”

Synthesis, Spectral characterization and biological activity of Copper complexes with 6-Nitro-benzothiazole-2-yl-hydrazones derivatives

“…This enhanced activity of metal chelates is due to increased lipophilic nature of the metal ions in complexes. As comparatively with simple hydrazones, the benzothiazole hydrazones with metal complexes show an increasing of biological activity [2][3][4][5][6] .…”