Magnetic Nanoparticles in Immunoassays

Thanh, Nguyen Tk

doi:10.1201/b11760-14

Cited by 1 publication

(2 citation statements)

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“…A number of Giant Magnetoresistance based (GMR) sensors are being developed as fully integrated systems which can detect a small number of PMPs [ 10 ]. The RCM measurements are produced from the interaction of many PMPs; this means that the results will not be influenced by variability in PMP size or magnetite concentration that devices that measure few particles could be susceptible to [ 11 ]. In addition only PMPs that are non-aggregated can flow through nitrocellulose membranes and give results at the test and control line.…”

Section: Introductionmentioning

confidence: 99%

“…As the RCM is not fully integrated this device also has flexibility in the type of immunoassay conducted. The main advantages of the RCM device in comparison with GMRs and CMOS Hall sensors is in the speed of the assay time, with RCM measurements being collected over 1–2 min [ 14 ] the cost of the device, with component parts estimated at approximately $100 and the applicability of the sensor to be a hand-held device [ 11 ]. A detailed review of the merits of different magnetic sensors is described elsewhere [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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An Inexpensive, Fast and Sensitive Quantitative Lateral Flow Magneto-Immunoassay for Total Prostate Specific Antigen

et al. 2014

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We describe the detection characteristics of a device the Resonant Coil Magnetometer (RCM) to quantify paramagnetic particles (PMPs) in immunochromatographic (lateral flow) assays. Lateral flow assays were developed using PMPs for the measurement of total prostate specific antigen (PSA) in serum samples. A detection limit of 0.8 ng/mL was achieved for total PSA using the RCM and is at clinically significant concentrations. Comparison of data obtained in a pilot study from the analysis of serum samples with commercially available immunoassays shows good agreement. The development of a quantitative magneto-immunoassay in lateral flow format for total PSA suggests the potential of the RCM to operate with many immunoassay formats. The RCM has the potential to be modified to quantify multiple analytes in this format. This research shows promise for the development of an inexpensive device capable of quantifying multiple analytes at the point-of-care using a magneto-immunoassay in lateral flow format.

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Section: Introductionmentioning

confidence: 99%