Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

Abstract

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

“… 44 MHT can use various drug-loaded MNCs to i) closely control the heating yield by adjusting the applied AMF, ii) maintain the efficiency of the cancer treatments without detrimental side effects, and iii) consumption of less drug-administered to overcome the treatment shaping problems in the conventional chemotherapy alone. 17 , 176 Moreover, AMF is potentially capable of achieving “on/off” drug release from MNCs in target tissue with treatment scale-up capability compared to chemotherapy and surgery, which are confined to poor cancer treatment index and harmful side effects. The AMF strengths regulate hyperthermia temperature in the cell medium through the heating capacity of a magnetic nano heater measured by specific absorption rate (SAR) or the specific loss power (SLP).…”

“…This is due to their excellent structural properties including pH, thermo, and magneto-responsive along with high magnetization, colloidal stability, drug-conjugation, biodegradability, and biocompatibility manner. 4,17,18 In this manner, MNCs have been studied for MHT, [19][20][21][22][23] targeted drug delivery, 24,25 bioseparation, 26,27 biosensing, 28,29 cell labeling, 30 targeting and immunoassays, [31][32][33] targeted cancer therapy, 34,35 and magnetic resonance imaging (MRI). [36][37][38][39] In an ideal scenario of chemothermotherapy using MHT, alternating magnetic field (AMF) can generate local heating onto MNCs and also tumor cells for thermal treatment and also a heat-dependent release of drug to sensitize cancer cells.…”

“…This is due to their excellent structural properties including pH, thermo, and magneto-responsive along with high magnetization, colloidal stability, drug-conjugation, biodegradability, and biocompatibility manner. 4 , 17 , 18 In this manner, MNCs have been studied for MHT, 19–23 targeted drug delivery, 24 , 25 bioseparation, 26 , 27 biosensing, 28 , 29 cell labeling, 30 targeting and immunoassays, 31–33 targeted cancer therapy, 34 , 35 and magnetic resonance imaging (MRI). 36–39 …”

Computer-Aided Design on Image Detection: A Chronology Review

“…By relying on the deep learning convolutional neural network (CNN), a lung CT image segmentation algorithm was created by Guo et al, [27]. Yusefi et al, [28] review a synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.…”

Magnetohydrodynamic Effects in Mixed Convection of Ferrofluid Flow at Lower Stagnation Point on Horizontal Circular Cylinder

“…Ferrofluid is synthesized by several methods such as ball milling, co-precipitation and decomposition of the iron carbonyl because it is not found in nature. The research in creating and improving ferrofluid formulations in wide applications such as in electronic devices, military, aerospace and medical [4]. Nowadays, electronic devices like loudspeaker use ferrofluid to avoid the voice coil from overheating [5,6].…”