Magnetic nanoparticles as potential candidates for biomedical and biological applications

Sehrig, Fatemeh Zeinali; Majidi, Sima; Nikzamir, Nasrin; Nikzamir, Nasim; Nikzamir, Mohammad; Akbarzadeh, Abolfazl

doi:10.3109/21691401.2014.998832

Cited by 25 publications

(11 citation statements)

References 88 publications

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“…The property of super‐paramagnetism is beneficial over ferromagnetism for several biomedical applications, as super‐paramagnetic NPs show a high magnetic moment and work as a giant paramagnetic atom with a fast response to external magnetic fields with insignificant coercivity and remanence at room temperature . Nevertheless, ferromagnetic NPs can be super‐paramagnetic when they show single domains, typically with sizes below 20 nm . However, an inevitable issue associated with particles in this size range is their intrinsic instability and trend to aggregate in order to minimize the high surface energy resulting from their large surface‐to‐volume ratio .…”

Section: Magnetic Npsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

525

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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Section: Magnetic Npsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

525

330

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“…MTDDS is a stable system composed of a magnetic substance and drugs, using a suitable carrier. Under the external magnetic field with a specific intensity, the drug may be directionally moved, positioned, concentrated and released in vivo towards the lesions, thereby exerting its efficacies at the lesion site (5). The highly specific characteristic of this system has been previously demonstrated to significantly reduce the side effects (6).…”

Section: Introductionmentioning

confidence: 99%

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

Shan

Liu

et al. 2016

Molecular Medicine Reports

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This aim of the present study was to investigate the safety and toxicology of intravenous administration of angiopoietin-2 (Ang2)-small interfering (si)RNA plasmid-chitosan magnetic nanoparticles (CMNPs). Ang2-CMNPs were constructed and subsequently administered at different doses to mice and rats via the tail vein. The acute (in mice) and chronic toxicity (in rats) were observed. The results of the acute toxicity assay revealed that the LD50 mice was >707.0 mg·kg-1·d-1, and the general condition of mice revealed no obvious abnormalities. With the exception of the high dose group (254.6 mg·kg-1·d-1), which exhibited partial lung congestion, the other groups exhibited no obvious abnormalities. Results of the chronic toxicity assay demonstrated that the non-toxic dose of Ang2-CMNPs in the rat was >35.35 mg·kg-1·d-1 for 14 days. The rat general condition and blood biochemistry indexes revealed no obvious abnormality. The blood routine indexes and lung/body ratio of each treatment group were higher when compared with the control group. The middle- and high-dose groups exhibited chronic pulmonary congestion, whilst the low-dose and control groups exhibited no abnormality. Similarly, the other organs revealed no obvious abnormality. Ang2-CMNPs have good safety at a certain dose range and may be considered as the target drug carrier.

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“…The problem of recovering the spatial distribution of magnetic nanoparticles (MNPs) in a nondestructive way has gained a lot of importance due to an increased use of these particles in biomedical applications [1][2][3] such as hyperthermia, 4,5 drug targeting, 6,7 and disease detection. 8,9 These applications require a precise knowledge of the spatial position of the MNP in order to achieve a safe and reliable performance.…”

Section: Introductionmentioning

confidence: 99%