Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

Elsherbini, Alsayed A.; Saber, Mohamed; Aggag, Mohamed Farouk; El-Shahawy, Ahmed A. G.; Shokier, Hesham A.A.

doi:10.1016/j.mri.2010.08.010

Cited by 67 publications

(43 citation statements)

References 19 publications

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“…This strategy cooperatively inhibited proliferation and induced apoptosis in tumor cells. Similar application of hyperthermia was also reported by Elsherbini et al 30 where Fe 3 O 4 NPs were utilized to simultaneously raise the temperature to 47°C under radiofrequency exposures at 25 kW; at this point, the monitoring of the apoptotic cells presented dark signal intensity in the longitudinal relaxation time (T1)-weighted images, as investigated in Ehrlich tumors. In addition, synthesis of sugarcoated iron oxide NPs designed specifically as magnetic fluid hyperthermia heat mediators and negative contrast agent for MRI has also been described.…”

Section: Magnetic Nanomaterialssupporting

confidence: 54%

Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented.

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Section: Magnetic Nanomaterialssupporting

confidence: 54%

Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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“…Commercially available very small superparamagnetic particles are claimed to be suboptimal for effective tumor heating. In contrast, superparamagnetic magnetite nanoparticles were shown to be appropriate for inducing hyperthermia with radiofrequency to Ehrlich tumors (Elsherbini et al, 2011).…”

Section: Hyperthermia Treatmentmentioning

confidence: 97%

“…Temperatures up to 42 o C can render cancer cells more susceptible to the effect of irradiation and cause a certain degree of apoptosis, whereas temperatures >45°C are termed thermoablation and cause direct cell killing (necrosis) ( Elsherbini et al, 2011).…”

Section: Hyperthermia Treatmentmentioning

confidence: 99%

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Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak¹,

Yavuztürk²,

Sezer³

2012

Recent Advances in Novel Drug Carrier Systems

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“…Firstly, magnetic nanoparticles were prepared according to the method described by Elsherbini et al 19 The gold-coated magnetic nanoparticles were prepared as follows. A 0.01 mg aliquot of the prepared magnetic nanoparticles was suspended in 25 mL of glycerol.…”

Section: Preparation Of Nanocompositesmentioning

confidence: 99%

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

El-Sherbini¹

2011

IJN

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Introduction The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency. Methods Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice. Results In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared. Conclusion This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.

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Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

Cited by 67 publications

References 19 publications

Nanotheranostics – a review of recent publications

Nanotheranostics – a review of recent publications

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

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Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

Cited by 67 publications

References 19 publications

Nanotheranostics &ndash; a review of recent publications

Nanotheranostics &ndash; a review of recent publications

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

Contact Info

Product

Resources

About

Nanotheranostics – a review of recent publications

Nanotheranostics – a review of recent publications