Magnetic Nanoparticle Detection by Utilizing Nonlinear Magnetization for Sentinel Lymph Nodes of Breast Cancer Patients

Kuwahata, Akihiro; Taruno, Kanae; Kurita, Tomoyuki; Makita, Masujiro; Chikaki, Shinichi; Saito, Itsuro; Takei, Hiroyuki; Nakamura, Seigo; Kusakabe, Moriaki; Sekino, Masaki

doi:10.1109/tmag.2020.3010641

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Contrarily, the SNR of the third harmonic showed a decreasing trend, and a maximum value of 200, at B DC = 0 mT. The mechanism responsible for this phenomenon was Comparing the maximum SNR of the second and third harmonics, the second harmonic showed approximately three times the value of the third harmonic [4][5][6][7]. Additionally, the magnitude of the magnetic harmonics for the virus concentration of 100 μg/ml was smaller than that for the concentration of 0 μg/ml.…”

Section: Resultsmentioning

confidence: 94%

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Hirota

Murayama

Katsumi

et al. 2022

IEEJ Transactions Elec Engng

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Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R 24 ) and the ratio of the third harmonic to the fifth harmonic (R 35 ) shows that R 24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.

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Section: Resultsmentioning

confidence: 94%

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Hirota

Murayama

Katsumi

et al. 2022

IEEJ Transactions Elec Engng

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“…A magnetic nanoparticle detection device that uses non-linear magnetization was utilized to quantitate iron as described by Kuwahata et al [14].…”

Section: Methodsmentioning

confidence: 99%

“…Iron content in the freshly isolated lymph nodes was measured in the operating room using an iron quantification device developed at the University of Tokyo [14]. Magnetic fields generated from the ferucarbotran in the SLN were also measured using a handheld magnetometer as described elsewhere [8].…”

Section: Methodsmentioning

confidence: 99%

Exploratory Study of Superparamagnetic Iron Oxide Dose Optimization in Breast Cancer Sentinel Lymph Node Identification Using a Handheld Magnetic Probe and Iron Quantitation

Taruno

Kuwahata

Sekino

et al. 2022

Cancers

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This exploratory study compared doses of ferucarbotran, a superparamagnetic iron oxide nanoparticle, in sentinel lymph nodes (SLNs) and quantified the SLN iron load by dose and localization. Eighteen females aged ≥20 years scheduled for an SLN biopsy with node-negative breast cancer were divided into two equal groups and administered either 1 mL or 0.5 mL ferucarbotran. Iron content was evaluated with a handheld magnetometer and quantification device. The average iron content was 42.8 µg (range, 1.3–95.0; 0.15% of the injected dose) and 21.9 µg (1.1–71.0; 0.16%) in the 1-mL and 0.5-mL groups, respectively (p = 0.131). The iron content of the closest SLN compared to the second SLN was 53.0 vs. 10.0 µg (19% of the injected dose) and 34.8 vs. 4.1 µg (11.1%) for the 1-mL and 0.5-mL groups, respectively (p = 0.001 for both). The magnetic field was high in both groups (average 7.30 µT and 6.00 µT in the 1-mL and 0.5-mL groups, respectively) but was not statistically significant (p = 0.918). The magnetic field and iron content were correlated (overall SLNs, p = 0.02; 1-mL, p = 0.014; 0.5-mL, p = 0.010). A 0.5-mL dose was sufficient for SLN identification. Primary and secondary SLNs could be differentiated based on iron content. Handheld magnetometers could be used to assess the SLN iron content.

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Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

et al. 2023

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Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.

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Magnetic Nanoparticle Detection by Utilizing Nonlinear Magnetization for Sentinel Lymph Nodes of Breast Cancer Patients

Cited by 4 publications

References 17 publications

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Exploratory Study of Superparamagnetic Iron Oxide Dose Optimization in Breast Cancer Sentinel Lymph Node Identification Using a Handheld Magnetic Probe and Iron Quantitation

Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

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