Magnetic nanomaterials and sensors for biological detection

Sobczak-Kupiec, Agnieszka; Venkatesan, Jayachandran; Alanezi, Adnan Alhathal; Walczyk, Dorota; Farooqı, Ammad Ahmad; Malina, Dagmara; Hosseini, Seyed Hossein; Tyliszczak, Bożena

doi:10.1016/j.nano.2016.07.003

Cited by 53 publications

(16 citation statements)

References 112 publications

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“…Moreover, considering their tendency to agglomeration due to van der Waal and dipole–dipole attractions, and their sensitivity to oxygen, pH, and salts in the environment, the surface of these particles must be modified to increase their physical and chemical stability by providing steric and Coulomb repulsions [40,41]. Nanoparticle surface coatings are usually performed in the synthesis stage, and they involve polymeric coatings using different natural and synthetic structures, such as chitosan, dextran, cellulose, polyethylene glycol, polyvinyl alcohol, polystyrene, or polyethylene imine, liposomes and micelles utilization, core-shell structures using silica, and metallic coatings, such as gadolinium, or other hybrid materials [36,43,44,45,46]. Additionally, magnetic particles can be functionalized with different compounds in order to provide functional groups for further bioactive molecule conjugations [41] through different techniques, such as direct binding, Hong’s method, or bioremediation [40].…”

Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

“…The other direction of applications in molecular diagnosis is represented by the molecular detection of biomolecules labeled with magnetic particles. Commonly used biosensors based on magnetic particles with various sensing properties include magnetic-particle-relaxation-based sensors, magnetoresistive sensors, and magnetic relaxation sensors [44]. Moreover, there are many technologies available for magnetic particle detection, such as superconducting quantum interference devices, atomic magnetometers, and diamond-based magnetometers.…”

Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

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Magnetic Particles for Advanced Molecular Diagnosis

2019

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Molecular diagnosis is the field that aims to develop nucleic-acid-based analytical methods for biological markers and gene expression assessments by combining laboratory medicine and molecular genetics. As it gradually becomes a clinical reality, molecular diagnosis could benefit from improvements resulting from thorough studies that could enhance the accuracy of these methods. The application of magnetic particles in molecular diagnosis tools has led to tremendous breakthroughs in terms of specificity, sensitivity, and discrimination in bioassays. Therefore, the aim of this review is to highlight the principles involved in the implementation of magnetic particles for sample preparation and targeted analyte isolation, purification, and extraction. Furthermore, the most recent advancements in the area of cancer and infectious disease diagnosis are presented, with an emphasis on screening and early stage detection.

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Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

Magnetic Particles for Advanced Molecular Diagnosis

2019

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“…Nanotechnology in combination with natural science has emerged to become a powerful tool for investigating challenging biological questions. 23,24 Inspired by the human olfactory system, chemical nose sensing was developed as a hypothesis-free, signature-based tool to identify complex bioanalytes. 25–27 Gold nanoparticles (AuNPs) with tunable surface functionality and strong quenching ability 28 are ideal for constructing nanosensors.…”

Section: Introductionmentioning

confidence: 99%

Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays

Geng

Goel

et al. 2018

Nanomedicine: Nanotechnology, Biology and Medicine

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Cancer stem cells (CSCs) contribute to multidrug resistance, tumor recurrence and metastasis, making them prime therapeutic targets. Their ability to differentiate and lose stem cell properties makes them challenging to study. Currently, there is no simple assay that can quickly capture and trace the dynamic phenotypic changes on the CSC surface. Here, we report rapid discrimination of breast CSCs from non-CSCs using a nanoparticle-fluorescent-protein based sensor. This nanosensor was employed to discriminate CSCs from non-CSCs, as well as CSCs that had differentiated in vitro in two breast cancer models. Importantly, the sensor platform could also discriminate CSCs from the bulk population of cells in patient-derived xenografts of human breast cancer. Taken together, the results obtained demonstrate the feasibility of using the nanosensor to phenotype CSCs and monitor their fate. Furthermore, this approach provides a novel area for therapeutic interventions against these challenging targets.

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“…As a typical nanomaterial, magnetic nanoparticles (MNPs) mainly contain nanoparticles of magnetite (Fe 3 O 4 ) and maghemite ( -Fe 2 O 3 ), their dopant compound (MFe 2 O 4 , where M = Mn, Co, Zn, etc. ), and intermetallic system (e.g., Nd 2 Fe 14 B, SmCo 5 ) [1,2]. MNPs display their size within dozens to hundreds of nanometers and have a high specific surface area.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

Chen

Wang

et al. 2017

Journal of Nanomaterials

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The interaction of magnetic nanoparticles (MNPs) with various magnetic fields could directly induce cellular effects. Many scattered investigations have got involved in these cellular effects, analyzed their relative mechanisms, and extended their biomedical uses in magnetic hyperthermia and cell regulation. This review reports these cellular effects and their important applications in biomedical area. More importantly, we highlight the underlying mechanisms behind these direct cellular effects in the review from the thermal energy and mechanical force. Recently, some physical analyses showed that the mechanisms of heat and mechanical force in cellular effects are controversial. Although the physical principle plays an important role in these cellular effects, some chemical reactions such as free radical reaction also existed in the interaction of MNPs with magnetic fields, which provides the possible explanation for the current controversy. It is anticipated that the review here could provide readers with a deeper understanding of mechanisms of how MNPs contribute to the direct cellular effects and thus their biomedical applications under various magnetic fields.

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Magnetic nanomaterials and sensors for biological detection

Cited by 53 publications

References 112 publications

Magnetic Particles for Advanced Molecular Diagnosis

Magnetic Particles for Advanced Molecular Diagnosis

Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

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