Magnetic molecularly imprinted conducting polymer for determination of praziquantel enantiomers in milk

Abstract

A new selective adsorbent based on magnetic molecularly imprinted conducting polymer was firstly synthetized and applied to the magnetic solid phase extraction (MSPE) for the determination of PZQ enantiomers in milk samples.

Application progress of magnetic molecularly imprinted polymers chemical sensors in the detection of biomarkers

“…In the adsorption and quantitative analysis of biomarkers, many other materials can be modified on Fe 3 O 4 microspheres. For example, poly(glycidyl methacrylate), 61 2-anilinoethanol, 62 porous TiO 2 , 63 chitosan, 64 carbon quantum dots, 65 ionic liquids, 66 reduced graphene oxide (rGO), 67 metal–organic frameworks (MOF), 68 pyrrole, 69 dopamine 65 and other substances can enhance the performance of magnetic materials and assist the imprinting process. Of course, Fe 3 O 4 microspheres can also be directly bonded with functional groups.…”

“…Among them, functional monomers, which affect ligand receptor interactions and determine the affinity and selectivity of MIPs, are indispensable components in the preparation of MIPs. Despite the trend of gradual simplification of the current MIPs imprinting methods, some natural functional monomers such as pyrrole, 69 dopamine, 65 and norepinephrine 149 have been applied, but there are many alternative kinds of functional monomers. Before imprinting, multiple preselection experiments need to be carried out to obtain the functional monomer most suitable for the template molecule.…”

A Review on Molecularly Imprinted Polymers Preparation by Computational Simulation-Aided Methods

“…On the basis of the negative values of ΔG and ΔH, this results in the complexation of the monomer with praziquantel in aqueous solution spontaneously forming stable complexes. Moreover, the results of molecular geometric conformation simulation showed that four hydrogen bonds and one π–π stacking interaction are established between praziquantel and pyrrole, which explains the formation of praziquantel and pyrrole prepolymer complex at the molecular level [ 125 ]. Through PM3 and DFT theoretical simulation methods, the Muliken charge on each atom of the fluazuron optimized geometric structure can be obtained, which can quantitatively reveal the existence of six regions with a high electron charge density.…”

Recent Advances in Molecular-Imprinting-Based Solid-Phase Extraction of Antibiotics Residues Coupled With Chromatographic Analysis

“…The validated PT-MIP-SPE proved to be economical, simple, easy-to-perform, and potentially applicable for the extraction of MALs in complicated samples. Nascimento et al (2020) firstly synthesized a new selective adsorbent based on magnetic molecularly imprinted polypyrroleconducting polymer (MMIPPy) and applied it to the MSPE of praziquantel (PZQ) enantiomers [(R)-(−)-PZQ and (S)-(+)-PZQ] combined with HPLC-DAD determination. Under optimal conditions, excellent linearity was attained in a range of 0.01-10 µg/ml, with correlation coefficients higher than 0.98 and RSDs less than 15%.…”