A novel copper-catalyzed ATRA reaction of alkenes with α-bromoacetonitrile for the synthesis of γ-bromonitriles and β,γ-unsaturated nitriles was developed.

Molecularly imprinted ratiometric fluorescence (MIR-FL) nanosensors feature recognition selectivity, detection sensitivity, application universality, visualization accuracy, and device portability, and have gained popularity. However, the fluorescence intensity, nanostructure, color range, and practical application of the sensor still face severe difficulties to be solved. New strategies combined with various technologies have been developed to construct MIR-FL nanosensors for expanded applications. This Perspective highlights current resarch challenges and future prospects involving constructions and applications of MIR-FL nanosensors including dual-emission and triple-emission modes. The postimprinting mixing/ modification strategies, microdevices, and multitarget detection are focused, and technology synergy, sensitivity/reproducibility improvement, application diversity/portability, etc. are proposed.

Abuse and residues of antibiotics cause great harm to organisms and the environment. Appropriate sample pretreatment is usually required for sensitive determination, because of the low content presence of a variety of antibiotics in complicated matrices. Molecular-imprinting-based solid-phase extraction (MISPE) has been widely used for sample pretreatment of antibiotics, using molecularly imprinted polymers (MIPs) as adsorbents. Herein, we comprehensively review the recent advances of MISPE of antibiotics, followed by chromatographic analysis. Various solid-phase extraction (SPE) modes based on MIPs are briefly introduced, such as conventional SPE, dispersive SPE, magnetic SPE, matrix solid-phase dispersion, and pipette-tip SPE. Then, several emerging preparation techniques for antibiotics MIPs are summarized including surface imprinting, nanoimprinting, living/controlled radical polymerization, multitemplate imprinting, multifunctional monomer imprinting, and dummy template imprinting. Subsequently, applications of MISPE to analysis of a variety of antibiotics residues since 2018 are overviewed, including sulfonamides, quinolones, tetracycline, and others. Finally, the preparation and application of antibiotics MIPs are prospected.