Magnetic mixed hemimicelle solid-phase extraction based on mixed hemi-/ad-micelle SDS-coated magnetic nanoparticles Fe_2-xAl_xO₃ (x = 0.4) for the fluorimetric determination of carvedilol in biological samples

Abstract

Mixed hemi-/ad-micelle SDS-coated magnetic nanoparticles (Fe2-xAlxO3 (x = 0.4)) were used as an efficient adsorbent for the extraction and preconcentration of carvedilol (CVD) based on magnetic mixed hemimicelle solid-phase extraction. The Fe2-xAlxO3 magnetic nanoparticles not only have better stability and resistance to acidity, as well as alkalinity, but also are easy to prepare, inexpensive, and environmentally friendly. Several parameters that affected the extraction efficiency were investigated, including the type and volume of desorption solvent, extraction and desorption times, pH of the solution, zeta potential, and amounts of adsorbent and surfactant. Under the optimized extraction conditions, the developed method showed good linearity (R2 = 0.9998) within the range of 0.02–2.7 ng mL−1, and the limit of detection was 0.009 ng mL−1. The spiked recoveries of CVD in urine and plasma samples ranged from 101.50% to 111.00%. To the best of our knowledge, this is the first time that a mixed hemi-/ad-micelle solid-phase extraction method based on magnetic separation and nanoparticles has been used as a simple and sensitive method for the monitoring of CVD in biological samples.

Development of a micelle‐enhanced high‐throughput fluorometric method for determination of niclosamide using a microplate reader

“…As known, the addition of surfactants to a fluorophore solution at concentrations over their critical micelles concentration increases its quantum yield and/or its molar absorptivity (Scheme ) …”

Magnetic Solid-Phase Microextraction Protocol Based on Didodecyldimethylammonium Bromide-Functionalized Nanoparticles for the Quantification of Epirubicin in Biological Matrices

“…The use of surfactants is an interesting approach in the functionalization of NPs, as these chemicals possess hydrophobic and hydrophilic portions, as well as different orientations, on their surface, which allows the sorbents to be adjusted based on the experimental conditions. Due to the electrostatic and hydrophobic interactions of surfactants, the use of these positively or negatively charged structures with long hydrophobic chains can improve the adsorption of analytes onto the sorbent surface, thus providing higher extraction efficiencies compared to uncoated NPs [15,16].…”

Dispersive admicelle solid‐phase extraction based on sodium dodecyl sulfate coated Fe3O4 nanoparticles for the selective adsorption of three alkaloids in Gegen‐Qinlian oral liquid before high‐performance liquid chromatography

“…Compared with traditional sorbents, magnetic nanoparticles possess strong superparamagnetism properties and large surface area which can provide high adsorption capability, rapid extraction and separation from the sample solution by applying a strong magnetic field in a batch system . So, in recent years, magnetic mixed hemimicelle SPE has been widely used for the extraction and preconcentration of various analytes, such as pharmaceuticals , bioactive constituents , herbicides , phenolic pollutants , and food colorants . However, to the best of our knowledge, there is no report on the dispersive admicelle SPE based on SDS‐coated Fe 3 O 4 nanoparticles (NPs) for the adsorption of alkaloids.…”