Magnetic manipulation of superparamagnetic nanoparticles in a microfluidic system for drug delivery applications

Agiotis, L.; Theodorakos, Ioannis; Samothrakitis, Stavros; Papazoglou, Symeon; Raptis, Y. S.

doi:10.1016/j.jmmm.2015.10.111

Cited by 71 publications

(29 citation statements)

References 22 publications

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“…Nowadays, the use of magnetic nanoparticles as drug transporters has been an area of significant interest [5]. Besides its biocompatibility, one reason for using magnetite Fe 3 O 4 nanoparticles in this type of delivery system, is given by the possibility of applying any of the previously mentioned targeting approaches: passive by EPR [6], and active by magnetic targeting [7,8,9,10] or specific functionalizing [11,12,13,14]. Fe 3 O 4 nanoparticles have been already used as carriers for GEM in some in vitro approaches aiming to improve the drug release time [15], and efficiency [16,17].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characterization was performed by XRD, SEM, SAED and HRTEM; the functionalizing of magnetite with anti-tumor substances has been highlighted through TGA. The interaction with biologic media has been studied by means of stability and agglomeration tendency (using DLS and Zeta Potential); also, the release kinetics of the drug in culture media was evaluated. Cytotoxicity of free-Gemcitabine and the obtained nanoconjugate were evaluated on human BT 474 breast ductal carcinoma, HepG2 hepatocellular carcinoma and MG 63 osteosarcoma cells by MTS. In parallel, cellular morphology of these cells were examined through fluorescence microscopy and SEM. The localization of the nanoparticles related to the cells was studied using SEM, EDX and TEM. Hemolysis assay showed no damage of erythrocytes. Additionally, an in vivo biodistribution study was made for tracking where Fe3O4@Gemcitabine traveled in the body of mice. Our results showed that the transport of the drug improves the cytotoxic effects in comparison with the one produced by free Gemcitabine for the BT474 and HepG2 cells. The in vivo biodistribution test proved nanoparticle accumulation in the vital organs, with the exception of spleen, where black-brown deposits have been found. These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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“…In order to retain SPIONs, the magnetic force on a SPION (eq. 1) should overcome the force of the fluid flow derived from Stoke's Law [31][32][33][34]: = 6 (eq. 3).…”

Section: Discussionmentioning

confidence: 99%

Design and development of a magnetic device for mesenchymal stem cell retaining in deep targets

Banis

2017

J. Phys.: Conf. Ser.

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View the article online for updates and enhancements.Related content MRI evaluation of frequent complications after intra-arterial transplantation of mesenchymal stem cells in rats D Namestnikova, I Gubskiy, A Gabashvili et al. Abstract. This paper focuses on the retaining of mesenchymal stem cells in blood flow conditions using the appropriate magnetic field. Mesenchymal stem cells can be tagged with magnetic nanoparticles and thus, they can be manipulated from distance, through the application of an external magnetic field. In this paper the case of kidney as target of the therapy is being studied.

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“…Most probes use either immobilized antibodies, which capture viral particles through antigen-antibody interactions or DNA hybridization probes, which consist of a specific single-stranded nucleotide sequence complimentary to the target viral ssDNA or RNA, or ligand-functionalized NP via Au plasmon shift [12]. Depending on the probe architecture, binding could result in viral particle aggregation [13][14][15][16][17][18][19], collection on a 2D or 3D structure [20][21][22][23][24][25][26], or simply the creation of an individually "labelled" viral particle [27,28]. The ultimate detection method depends on the unique experiment design.…”

Section: Diffusionmentioning

confidence: 99%

Recent Advances in Nanoparticle Concentration and Their Application in Viral Detection Using Integrated Sensors

Dincau

Yong-Kuk

Kim

et al. 2017

Sensors

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Early disease diagnostics require rapid, sensitive, and selective detection methods for target analytes. Specifically, early viral detection in a point-of-care setting is critical in preventing epidemics and the spread of disease. However, conventional methods such as enzyme-linked immunosorbent assays or cell cultures are cumbersome and difficult for field use due to the requirements of extensive lab equipment and highly trained personnel, as well as limited sensitivity. Recent advances in nanoparticle concentration have given rise to many novel detection methodologies, which address the shortcomings in modern clinical assays. Here, we review the primary, well-characterized methods for nanoparticle concentration in the context of viral detection via diffusion, centrifugation and microfiltration, electric and magnetic fields, and nano-microfluidics. Details of the concentration mechanisms and examples of related applications provide valuable information to design portable, integrated sensors. This study reviews a wide range of concentration techniques and compares their advantages and disadvantages with respect to viral particle detection. We conclude by highlighting selected concentration methods and devices for next-generation biosensing systems.

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Magnetic manipulation of superparamagnetic nanoparticles in a microfluidic system for drug delivery applications

Cited by 71 publications

References 22 publications

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Design and development of a magnetic device for mesenchymal stem cell retaining in deep targets

Recent Advances in Nanoparticle Concentration and Their Application in Viral Detection Using Integrated Sensors

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