Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard

Dosev, Dosi; Nichkova, Mikaela; Dumas, Randy K.; Gee, Shirley J.; Hammock, Bruce D.; Liu, Kai; Kennedy, Ian M.

doi:10.1088/0957-4484/18/5/055102

Cited by 103 publications

(76 citation statements)

References 38 publications

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“…Detailed physical mechanisms elucidating the magnetic properties of the REdoped GdF 3 nanoparticles have been given in our previous report [11]. The magnetization at 20 kOe (at 293 K) is around 2 emu/g, which is near to the reported value of the nanoparticles used for common bio-separation [11][12][13]. …”

Section: Resultsmentioning

confidence: 51%

“…It is therefore desirable to increase the NIR-to-visible ratio by suppressing the intensity of the visible emission. Furthermore, nearly pure NIR-to-NIR upconverting multifunctional nanoparticles with both luminescent and magnetic properties are seldom reported [11][12][13]. Besides, autofluorescence causes severe problems in, especially the ill-posed, fluorescence diffuse optical tomography (FDOT).…”

Section: Introductionmentioning

confidence: 99%

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Towards pure near-infrared to near-infrared upconversion of multifunctional GdF_3:Yb^3+,Tm^3+ nanoparticles

Wong¹,

Chan²,

Hao³

2010

Opt. Express

106

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Nearly pure near-infrared to near-infrared (NIR-to-NIR) upconversion in GdF 3 host with 23% Yb 3+ and 1% Tm 3+ under 980 nm excitation is firstly reported. The ratio of the intensity of the emission at 807 nm to that at 478 nm can reach to 105, and the intensity of the emission at 807 nm is preserved. Moreover, the excitation and the emission at 980 and 807 nm are away from the visible region. These are beneficial to deeper tissue penetration and reduced autofluorescence. Raman spectroscopy measurements suggest the high probability of NIR emission in GdF 3 host. Our results indicate that the reported multifunctional nanoparticles are promising in bio-imaging and bio-separation. ©2010 Optical Society of America

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Section: Resultsmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Towards pure near-infrared to near-infrared upconversion of multifunctional GdF_3:Yb^3+,Tm^3+ nanoparticles

Wong¹,

Chan²,

Hao³

2010

Opt. Express

106

View full text Add to dashboard Cite

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“…Bone defects are repaired by using calcium phosphate [76]. Core-shell structured particles of magnetic and luminescent properties are reported to be prepared by spray pyrolysis [127].…”

Section: Bio-ceramicsmentioning

confidence: 99%

Design of particles by spray pyrolysis and recent progress in its application

Jung

Park

Kang

2010

Korean J. Chem. Eng.

137

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Spray pyrolysis is a promising aerosol process to produce "designer particles" of precisely controlled morphology with decorations on surfaces or inside particles. Need of precise control of properties has sparked researches on aerosol process that may replace conventional processes such as solid state reaction process or liquid precipitation method. However, productivity is the biggest obstacle in the development of a commercial scale process because the aerosol process is essentially operated at low particle concentration compared to liquid phase processes. In this review, by reviewing publications for the last 10 years we discuss how researchers on spray pyrolysis circumvent this inherent limitation of the aerosol process. First, the process of particle design by spray pyrolysis is introduced. Some key criteria are explained for selecting each component of spray pyrolysis: precursor, additive, carrier gas, heat source, and reactor type. Second, key contributions of major groups in Korea, Japan, Europe, and America are described. Third, some of named processes to overcome productivity of spray aerosol process are introduced. Fourth, applications of spray pyrolysis to materials related to alternative energy, environmental cleaning, information processing and display, and biomaterials are considered. Finally, future prospects of spray pyrolysis are discussed along with current standing issues for further progress of spray pyrolysis.

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“…An interesting possibility is to use magnetic Co:Nd:Fe 2 O 3 (core) luminescent Eu: Gd 2 O 3 (shell) core-shell nanoparticles with diameter 200-400 nm in immunoassays, enabling manipulation of nanoparticles by an external magnetic field during the separation and washing steps [119,120]. The magnetic field can be utilized to improve the washing efficiency for removing weakly bound nanoparticles (nonspecific binding) from the solid phase.…”

Section: Advanced Featuresmentioning

confidence: 99%

Lanthanide Nanoparticules as Photoluminescent Reporters

Soukka

Härmä

2010

Lanthanide Luminescence

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Luminescent lanthanide nanoparticles provide a combination of high luminescence intensity, long luminescence lifetime, sharp emission peaks with narrow bandwidth, and a large Stokes' shift, leading to a high-performance reporter technology for bioanalytical assays. The high specific activity of luminescent lanthanide nanoparticles enables improved assay sensitivities compared to the conventional fluorescent reporters, and the different luminescent lanthanide ions with well-separated emission wavelengths facilitate multiparametric assays. The versatility of lanthanide chelate-doped polymeric nanoparticles as reporters is further increased by the use of the most effective organic light-harvesting ligands optimized for enhanced luminescence and the availability of inexpensive highpower solid-state light sources. Moreover, entrapping within polymeric nanoparticles allows the use of the lanthanide complexes with a weak water solubility or a low thermodynamic stability. In this review, we discuss the effects of nanoparticle composition, particle size, synthesis, surface modification, and biomolecule conjugation on the assay performance in addition to applications of these reporters in both heterogeneous and homogeneous assays. In the future, additional value may be provided by hybrid lanthanide nanoparticles, which combine, e.g., luminescent and magnetic properties for detection and controlling the assay kinetics and washing efficiency.

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Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard

Cited by 103 publications

References 38 publications

Towards pure near-infrared to near-infrared upconversion of multifunctional GdF_3:Yb^3+,Tm^3+ nanoparticles

Towards pure near-infrared to near-infrared upconversion of multifunctional GdF_3:Yb^3+,Tm^3+ nanoparticles

Design of particles by spray pyrolysis and recent progress in its application

Lanthanide Nanoparticules as Photoluminescent Reporters

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