Magnetic iron oxide nanoparticles as drug delivery system in breast cancer

Marcu, Aurelian; Pop, Sevinci; Dumitrache, Florian; Mocanu, Mihaela Andreea; Niculite, Cristina Mariana; Gherghiceanu, Mihaela; Lungu, C.P.; Fleaca, C.; Ianchiş, Raluca; Barbut, A.; Grigoriu, C.; Morjan, I.

doi:10.1016/j.apsusc.2013.02.072

Cited by 98 publications

(49 citation statements)

References 15 publications

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“…They did not cause long-term changes in liver enzymes levels or induce oxidative stress in male Sprague-Dawley rats, and were completely eliminated from the organism 3 weeks after intravenous (IV) administration. On the other hand, Marcu et al 16 targeted a MCF-17 breast cancer cell line delivering iron oxide nanoparticles loaded with Violamycine B1, an anthracycline antibiotic that enhanced cellular uptake activity and cell death. Sun et al 17 showed that toxicity depends more strongly on the surface coating than the amount of iron oxide present in the cell.…”

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confidence: 99%

Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

Uchiyama¹,

Toma²,

Rodrigues³

et al. 2015

IJN

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Fully dispersible, cationic ultrasmall (7 nm diameter) superparamagnetic iron oxide nanoparticles, exhibiting high relaxivity (178 mM −1 s −1 in 0.47 T) and no acute or subchronic toxicity in Wistar rats, were studied and their suitability as contrast agents for magnetic resonance imaging and material for development of new diagnostic and treatment tools demonstrated. After intravenous injection (10 mg/kg body weight), they circulated throughout the vascular system causing no microhemorrhage or thrombus, neither inflammatory processes at the mesentery vascular bed and hepatic sinusoids (leukocyte rolling, adhesion, or migration as evaluated by intravital microscopy), but having been spontaneously concentrated in the liver, spleen, and kidneys, they caused strong negative contrast. The nanoparticles are cleared from kidneys and bladder in few days, whereas the complete elimination from liver and spleen occurred only after 4 weeks. Ex vivo studies demonstrated that cationic ultrasmall superparamagnetic iron oxide nanoparticles caused no effects on hepatic and renal enzymes dosage as well as on leukocyte count. In addition, they were readily concentrated in rat thigh by a magnet showing its potential as magnetically targeted carriers of therapeutic and diagnostic agents. Summarizing, cationic ultrasmall superparamagnetic iron oxide nanoparticles are nontoxic and efficient magnetic resonance imaging contrast agents useful as platform for the development of new materials for application in theranostics.

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confidence: 99%

Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

Uchiyama¹,

Toma²,

Rodrigues³

et al. 2015

IJN

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show abstract

“…Inorganic NPs, as potential diagnostic and therapeutic systems, are of growing interest in the field of oncology [26]. However, successful NPs for practical application must undergo functionalization with specific biomolecules, which allows NPs to target at the desired location, reducing toxicity to the whole body.…”

Section: Functionalization Of Nano-tiomentioning

confidence: 99%

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

Gao

Han

Wang

et al. 2015

Materials Science in Semiconductor Processing

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“…These cell types were chosen considering the intended use of the selected MNPs for theranostics in breast cancer [22].…”

Section: Preclinical In Vitro Studymentioning

confidence: 99%

Highly magnetic Fe2O3 nanoparticles synthesized by laser pyrolysis used for biological and heat transfer applications

Dumitrache

Morjan

Fleaca

et al. 2015

Applied Surface Science

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Magnetic iron oxide nanoparticles as drug delivery system in breast cancer

Cited by 98 publications

References 15 publications

Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

Highly magnetic Fe2O3 nanoparticles synthesized by laser pyrolysis used for biological and heat transfer applications

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