Magnetic images of the disintegration process of tablets in the human stomach by ac biosusceptometry

Abstract

Oral administration of solid dosage forms is usually preferred in drug therapy. Conventional imaging methods are essential tools to investigate the in vivo performance of these formulations. The non-invasive technique of ac biosusceptometry has been introduced as an alternative in studies focusing on gastrointestinal motility and, more recently, to evaluate the behaviour of magnetic tablets in vivo. The aim of this work was to employ a multisensor ac biosusceptometer system to obtain magnetic images of disintegration of tablets in vitro and in the human stomach. The results showed that the transition between the magnetic marker and the magnetic tracer characterized the onset of disintegration (t(50)) and occurred in a short time interval (1.1 +/- 0.4 min). The multisensor ac biosusceptometer was reliable to monitor and analyse the in vivo performance of magnetic tablets showing accuracy to quantify disintegration through the magnetic images and to characterize the profile of this process.

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

“…Afterwards, the images are submitted to the digital image processing tools. Details about this method to obtain images with ACB sensor were reported earlier (14).…”

“…ACB sensors are versatile tools for monitoring solid dosage forms in vitro and in vivo through magnetic signals as well as magnetic images (13)(14)(15)(16)(17)98). The major advantage of this method is the capability for recording GI motility in real time.…”

“…Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) are the noninvasive and radiation-free sensors currently available for pharmaceutical purposes. Such techniques provide effective monitoring of a number of pharmaceutical processes in vitro as well as under the influence of physiological parameters (13)(14)(15)(16)(17)(18)(19)(20). The key aspects regarding the biomagnetic methods from theory to practice will be exploited in this review.…”

Enteric Coated Magnetic HPMC Capsules Evaluated in Human Gastrointestinal Tract by AC Biosusceptometry

“…2). This system is fixed in a vertical support to be positioned on the abdominal surface and to acquire the magnetic signals at different points (17,18,24,25).…”

“…A multisensor ACB system was implemented to characterize the disintegration process of tablets in vitro and in the human stomach, through the acquisition of magnetic signals (17). In addition, this system was also employed to monitor magnetic tablets in GI tract and to image the disintegration process, introducing a novel technique in imaging of the biological systems (18,24,25).…”