AC Biosusceptometry Technique to Evaluate the Gastrointestinal Transit of Pellets under Influence of Prandial State

Miranda, José Ricardo de Arruda; Corá, Luciana Aparecida; Américo, Madileine Francely; Romeiro, Fernando Gomes

doi:10.1002/jps.21794

Cited by 13 publications

(8 citation statements)

References 40 publications

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“…Further, magnetically marked tablets may be coated for improving appearance and stability, for taste masking, or for providing controlled drug release (13,98). As well as unit preparations, multiparticulate dosage forms can also be magnetically labeled (17,99). Pellets are spheres of varying diameter which may be manufactured by using classical extrusion-spheronization method or further techniques as spray-drying or layer building, in which the magnetic material can be added for labelling.…”

Section: Magnetic Labeling Of Solid Dosage Formsmentioning

confidence: 99%

“…ACB sensors are versatile tools for monitoring solid dosage forms in vitro and in vivo through magnetic signals as well as magnetic images (13)(14)(15)(16)(17)98). The major advantage of this method is the capability for recording GI motility in real time.…”

Section: Biosusceptometric Analysismentioning

confidence: 99%

“…In terms of drug delivery research, ACB sensors are feasible to monitor GI motility parameters in different segments as well as drug delivery process (11,13,15,17). Either magnetic markers or magnetic tracers can be detected; the difference is on the intensity and amplitude of the magnetic signal.…”

Section: Acb Systemmentioning

confidence: 99%

“…Under usual conditions, the gastric emptying time ranges from 5 min to 2 h. In general, the presence of food, especially fatty, reduces the gastric emptying time. Delayed gastric emptying might be exploited as an interesting approach to enhance the absorption of drugs presenting an absorption window in the upper GI tract (17,(68)(69)(70).…”

Section: Gastrointestinal Transitmentioning

confidence: 99%

“…Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) are the noninvasive and radiation-free sensors currently available for pharmaceutical purposes. Such techniques provide effective monitoring of a number of pharmaceutical processes in vitro as well as under the influence of physiological parameters (13)(14)(15)(16)(17)(18)(19)(20). The key aspects regarding the biomagnetic methods from theory to practice will be exploited in this review.…”

Section: Introductionmentioning

confidence: 99%

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Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

et al. 2010

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Biomagnetic methods have been designed for a wide range of applications. Recently, such methods have been proposed as alternatives to scintigraphy for evaluating of a number of pharmaceutical processes in vitro as well as under the influence of gastrointestinal physiological parameters. In this review, physical characterization as well as the most recent applications of Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) in the pharmaceutical research will be explored. Moreover, their current status and how these technologies can be employed to improve the knowledge about the impact of gastrointestinal physiology on drug delivery in association with pharmacokinetic outcomes, termed pharmacomagnetography, will be presented.

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Section: Magnetic Labeling Of Solid Dosage Formsmentioning

confidence: 99%

Section: Biosusceptometric Analysismentioning

confidence: 99%

Section: Acb Systemmentioning

confidence: 99%

Section: Gastrointestinal Transitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

et al. 2010

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Influence of Post-Transplant Immunosuppressive Therapy on Gastrointestinal Transit Using Biomagnetic Method: A Pilot Study

et al. 2014

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This study demonstrated that ACB is a suitable methodology when evaluating the influence of different immunosuppressive therapies on gastrointestinal transit after renal transplantation. Pronounced inter-individual variation was found in patients treated with tacrolimus, thus showing the prokinetic effect of this drug on GI motility. Studies of motility patterns in this population could be useful as complementary information toward determining the mechanisms and the relationship between motility and therapeutic doses.

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