Magnetic hyperthermia: Potentials and limitations

Folate ‐ Conjugated Magnetite Nanoparticles for Targeted Drug Delivery and Hyperthermia Applications

“…Magnetic hyperthermia is a kind of treatment which aims at increasing the temperature at specific tumorous area of the body from 40 °C to 43 °C. It can persuade cellular apoptosis of cancerous cells by increasing the effects of chemo/radiotherapy [58,59] . This type of increment in temperature of tissue induces some vascular changes, enhances blood flow, and finally causes oxygenation of tumor.…”

“…This type of increment in temperature of tissue induces some vascular changes, enhances blood flow, and finally causes oxygenation of tumor. Thus, hyperthermia alleviates hypoxia of tissue and can be concurrently applied to the chemotherapy or radiotherapy to enhance their killing effects on tumor [59,60] . It can affect the cellular structure actions, enzymes required for nucleic acid repair, cell membrane, protein etc [59] .…”

Therapeutic applications of magnetic nanoparticles: recent advances

“…MNPs are then subjected to an external magnetic field, to produce heat which raises the temperature of cancerous cells more than that in non-cancerous cells. 64 The benefit of this technique over chemotherapy is that it specifically targets the tumour and does not damage the surrounding healthy tissues, which thereby increase its efficiency over chemotherapy. Also, cancerous cells have a higher sensitivity to temperature than healthy cells, which is referred to as "thermos ablation".…”

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

“…Thermo-radiotherapy is a combination of hyperthermia therapy and radiotherapy for cancer treatment. Hyperthermia treatment, carried out by locally raising the temperature of tumors, can inhibit the repair of irradiation-induced DNA breaks [ 61 ], make cancer cells in the G1 and G2/M phases more sensitive to radiotherapy [ 62 ], and increase tumor oxygenation [ 63 ], generating synergistic effects. Magnetic nanoparticles can be used in thermo-radiotherapy under an external alternating magnetic field to evenly heat the tumors [ 63 , 64 ].…”

“…Hyperthermia treatment, carried out by locally raising the temperature of tumors, can inhibit the repair of irradiation-induced DNA breaks [ 61 ], make cancer cells in the G1 and G2/M phases more sensitive to radiotherapy [ 62 ], and increase tumor oxygenation [ 63 ], generating synergistic effects. Magnetic nanoparticles can be used in thermo-radiotherapy under an external alternating magnetic field to evenly heat the tumors [ 63 , 64 ]. For example, magnetic nanoparticles of 12 nm were directly injected into tumors of human glioblastoma multiforme patients, and subsequently heated under an alternating magnetic field.…”