Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles

Laurent, Sophie; Dutz, Silvio; Häfeli, Urs O.; Mahmoudi, Morteza

doi:10.1016/j.cis.2011.04.003

Cited by 1,185 publications

(740 citation statements)

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“…The temperature increase at range from 42 to 44 °C (temperature range used in clinical treatments by hyperthermia) significantly reduces cell viability of the tumor cells. 26,27 In this context, oncocalyxone-A (onco-A), a quinone ( Figure 1) obtained from the Auxemmaoncocalyx Taub. plant, was selected as a bioactive model compound for the purpose of this study.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

Almeida¹,

Gallo²,

Silva³

et al. 2017

J. Braz. Chem. Soc.

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This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporation method. The developed MSLNs were subjected to an external oscillating magnetic field and showed significant hyperthermia. The samples were exposed to frequencies of 688 and 869 kHz causing, respectively, a temperature increase of 15.5 and 22.7 °C (trilaurin-tricaprylin) and 17.3 and 26.1 °C (trilaurin-tricaprin). Also, in vitro assays in the absence of magnetic field showed that the triglyceride-based formulations were able first to encapsulate and then to sustained release an antitumoural hydrophobic drug. After 72 h of assay trilaurin-tricaprylin and trilaurin-tricaprin released 73 and 55% of their cargo, respectively. In addition, MSLN exhibited low in vitro cytotoxic activity against human neutrophils.Keywords: lipid mixture, magnetic hyperthermia, drug delivery, oncocalyxone-A IntroductionNanotechnology is an expanding sector and the use of superparamagnetic iron oxide nanoparticles (SPIONs) is attracting increasing attention in several areas. SPIONs are widely employed for biotechnological applications through the development of magnetic systems for use in: cell separation, as contrast agents for magnetic resonance imaging (MRI), magnetic hyperthermia, targeted bioactive compounds delivery and biosensors. [1][2][3][4] Such applications explore the biggest advantages of using SPIONs: biocompatibility and satisfactory magnetic response at applied magnetic field (superparamagnetic character). 5,6 The surface of the magnetic nanoparticles should be modified, not only in order to prevent oxidation and aggregation, but also to provide colloidal stability, reduced magnetic susceptibility, as well as to expand the effectiveness of cellular uptake and biodistribution. The hydroxyl groups present on the surface of nanoparticles can function as an anchor point for various types of compounds such as oleic acid, which is commonly used in the synthesis of magnetic ferrofluids. The criteria adopted to select the appropriate coating of magnetic nanoparticles depends mainly on the intended application. In the case of this research, magnetic nanoparticles made of iron oxide were coated with oleic acid (Fe 3 O 4 @OA) for subsequent incorporation into lipid carriers. 7-9The lipid carriers have been widely used as they also possess excellent characteristics such as biocompatibility Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications J. Braz. Chem. Soc. 1548 and versatility, and they have been proposed for the delivery of bioactive compounds by oral, intravenous, topical and parenteral routes. 10,11The solid lipid nanoparticles (SLNs) emerged in the early 90's and currently are alternative encapsulation systems and carriers o...

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Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

Almeida¹,

Gallo²,

Silva³

et al. 2017

J. Braz. Chem. Soc.

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“…Dentre as fases polimórficas do óxido de ferro, o Fe 2 O 3 (hematita) e o FeFe 2 O 4 (magnetita) são conhecidos por serem antiferromagnético e ferrimagnético, respectivamente. Estas características magnéticas podem ser alteradas dependendo do tipo de método de síntese utilizado na produção, o que pode conferir energia térmica suficiente para alterar a distribuição Dependendo do método de síntese utilizado a NPM à base de óxido de ferro apresenta grande superfície e elevada área de transferência de massa, estabilidade térmica e química, e baixa toxicidade, qualidades ideais para o uso em aplicações biomédicas [2,3], tais como: biossensores [4], carreadores de fármacos [5,6], agente de contraste nos exames por ressonância magnética [7], tratamento de hipertermia para células malignas e imunoensaios [8], purificação de DNA e RNA [9], separação de enzimas [10,11] e proteínas [12]. Porém, para estas aplicações as NPMs precisam apresentar alta área de superfície, baixa aglomeração, boa dispersão em fluidos corpóreos para se locomover dentro do corpo humano e acima de tudo comportamento magnético que permita ser facilmente atraída por um imã e desmagnetizem espontaneamente.…”

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Modificação da superfície de nanocompósitos de Fe2O3/Fe3O4 visando seu uso para imobilização da glicose oxidase

et al. 2017

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INTRODUÇÃOAs nanopartículas magnéticas (NPMs) Químico, Sabará, MG, patytaraujo@gmail.com, daniel.r.cornejo@gmail.com, dbrandao@jhs.med.br, libiaconrado@yahoo.com.br, ana.costa@ufcg.edu.br Resumo O aumento no número de pessoas portadoras de diabetes nos últimos anos e a elevada relação custo benefício da tecnologia de biossensores existentes têm motivado um crescente interesse no desenvolvimento de biossensores de detecção de glicose baseados na imobilização da glicose oxidase (GOD) utilizando-se principalmente nanopartículas magnéticas. Neste contexto, nanocompósitos de Fe 2 O 3 /Fe 3 O 4 foram sintetizados por reação de combustão e tiveram sua superfície modificada com 3-aminopropiltrimetoxissilano via reação de silanização e com quitosana via reação de funcionalização para obter um material híbrido que foi avaliado como possível imobilizador de GOD. As amostras foram caracterizadas por difração de raios X, espectroscopia de infravermelho com transformada de Fourier, análise termogravimétrica, microscopia eletrônica de varredura e de transmissão, propriedades magnéticas e citotoxidade in vitro. Os resultados mostraram que foi possível obter o compósito ferrimagnético, a modificação da superfície reduziu a magnetização de saturação, mas manteve a característica ferrimagnetica, e todas as amostras foram consideradas não tóxicas. Para os testes preliminares de imobilização da GOD foi revelado que o nanocompósito modificado com silano e quitosana apresentou melhor resultado, cerca de 2,7 mg de GOD imobilizados para cada 100 mg de nanocompósito, o que torna este material uma possível alternativa para ser utilizado na fabricação de bissensores de GOD. Palavras-chave: nanocompósitos, modificação da superfície, imobilização de GOD. Abstract The increase in the number of people with diabetes in recent years and the high cost-benefit ratio of the existing biosensor technology have increased the interest for the development of glucose detection biosensor based on immobilization of glucose-oxidase (GOD

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“…5 This allows highly localized thermo-ablation 6 and profi cient photodynamic therapies even in internal tissues due to the transformation of body-penetrating infrared radiation into visible light. 7 These approaches, some of which are already at the stage of clinical trials, increase the effi cacy of anticancer therapies, focusing toxic actions against tumor masses and sparing healthy tissues.…”

Section: The Goodmentioning

confidence: 99%

Biological interactions of oxide nanoparticles: The good and the evil

Ghibelli

Mathur

2014

MRS Bull.

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Metal oxide nanostructures can be broadly grouped into two categories, namely industrial and medicinal nanoparticles. Industrially engineered metal oxides are heavily used in various fi elds ranging from chemical industries, the automobile sector, environmental remediation, and food and cosmetic industries. The medicinal use of metal oxide nanoparticles is in rapid expansion and deals with highly reactive oxides (e.g., TiO 2 , FeO 2 , CeO 2 ) that deeply interfere with the metabolic network of cells and organisms. In addition to the nanoscale, which provides peculiar features to materials, nano-oxides develop interactions with the complex chemistry of living matter due to their surface reactivity, which is enhanced by their extremely high surface area to volume ratio. Moreover, their ability to shed ions that can alter the surrounding bioenvironment makes them especially reactive. Such reactivity on the one hand is a biohazard, but on the other, if correctly managed, can be turned into invaluable pharmaceutical tools.Oxide nanoparticles used for medicinal studies have, in general, well-defi ned surface chemistry due to the co-synthetic or post-synthetic conjugation of linker molecules-generally of organic nature-that prevents/modulates the release of metal ions in cellular environments and imparts colloidal stability, a parameter of paramount importance when nanoparticles travel within living organisms. In addition, surface functionalization with bifunctional linkers allows selective conjugation with biomolecules, and this imparts tailored properties, such as control of delivery and cellular uptake.

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Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles

Cited by 1,185 publications

References 214 publications

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

Modificação da superfície de nanocompósitos de Fe2O3/Fe3O4 visando seu uso para imobilização da glicose oxidase

Biological interactions of oxide nanoparticles: The good and the evil

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