Magnetic field response of aqueous hydroxyapatite based magnetic suspensions

Abstract

During the biomedical and biotechnological applications of hydroxyapatite based magnetic biomaterials the response to various magnetic fields (i.e. change in flow behavior) plays a pivotal role in manipulating these materials. Numerous studies discuss the synthesis, characterization and possible applications of magnetic hydroxyapatite, however the number of reports related to the magnetic response is limited. In this study we investigated the response of aqueous suspensions of magnetite/hydroxyapatite composites with gelatin as an additive to homogeneous and inhomogeneous magnetic fields. Under homogeneous field the change in rheological properties was determined, and correlated with the composition of the composites. The effect of magnetite and gelatin content on the zero field viscosity and magnetic susceptibility were also evaluated. The response to inhomogeneous field was characterized by measuring the magnetic body force acting on droplets of the aqueous suspensions. We found that the formulation of the composites and the presence of additive largely affect the magnetic response.

Design of Gelatin-Capped Plasmonic-Diatomite Nanoparticles with Enhanced Galunisertib Loading Capacity for Drug Delivery Applications

“…According to Figure 1 b(I), the irregular surface of DNPs was decorated by a carpet of AuNPs with a mean radius r of ~ 3 nm ( Figure 1 c). The presence of the gelatin shell covering the final AuDNP-LY@Gel x complex was confirmed by the surface of the complex becoming darker and smoother upon an increment of the gelatin concentration [ 29 , 30 ]. As evident from Figure 1 b(II,III), the gelatin shell on the biosilica surface covered the carpet of AuNPs, which were no longer visible by TEM analysis.…”

Functionalized iron oxide nanoparticles: synthesis through ultrasonic-assisted co-precipitation and performance as hyperthermic agents for biomedical applications

“…Iron oxide nanoparticles (IONPs) are widely applied in biomedical applications as they attain both high biocompatibility and superparamagnetic performance [ 1 , 2 , 3 , 4 , 5 ]. IONPs could be regarded as good heat mediators and drug delivery agents in the hyperthermia-based treatment of cancer [ 1 ].…”

One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

“…The preparation of a biocompatible magnetic composite using HAP and magnetic NPs was carried out using a number of approaches, such as an alkaline coprecipitation method [32], a two-stage deposition method [33], and a stoichiometric titration method [34]. The considered methods make it possible to obtain HAP/magnetic NPs composites; however, for bioapplications, it is necessary to carry out an additional operation, which ensures the fixation of drug molecules, antibodies, or genes on the composite surface.…”