Functionalized iron oxide nanoparticles: synthesis through ultrasonic-assisted co-precipitation and performance as hyperthermic agents for biomedical applications

Darwish, Mohamed S. A.; Al-Harbi, Laila M.

doi:10.1016/j.heliyon.2022.e09654

Cited by 25 publications

(10 citation statements)

References 42 publications

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“…Along with this, the peak observed at 2928 cm −1 , implies CH stretching. The sharp peak obtained at 1730 cm −1 , is assigned to CO stretching, indicating the successful formation of the PEMA/PVA composite 74 . The peak appeared at 1433 cm −1 attributed to CH bending.…”

Section: Resultsmentioning

confidence: 91%

Nano boron nitride laminated poly(ethyl methacrylate)/poly(vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging materials

Behera,

Patra,

Nazrul

et al. 2024

J of Applied Polymer Sci

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Herein, nano boron nitride (BN) laminated poly(ethyl methacrylate) (PEMA)/poly(vinyl alcohol) (PVA) nanocomposite films are fabricated by using a simple in situ polymerization technique with incorporation of silver nanoparticles (Ag NPs). Structural investigations of PEMA/PVA/Ag@BN nanocomposite thin films are carried out by Fourier‐transform infrared spectroscopy, dynamic light scattering, X‐ray diffraction analysis, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and mass spectrometry. The change in morphology of PEMA/PVA matrix due to the reinforcement of BN platelets are identified by electron microscopic studies. The unique tortuous paths are achieved by the dispersion of BN platelets by which gas penetration is restricted with enhancing the barrier properties of the material by 6.5 folds at 5 wt% BN content as compared with neat PEMA/PVA. Acid and alkali resistant along with biodegradability behavior of as‐synthesized nanocomposites are studied. From limiting oxygen index (LOI) results, it is found that the prepared materials are fire retardant in nature owing to effective reinforcement of BN layers. Antibacterial activities of PEMA/PVA/Ag@BN nanocomposite are studied by Xanthomonas citri or axonopodis pv. Citri, Escherichia coli, and Xanthomonas oryzae pv. Oryzae because of Ag NPs reinforcement. The substantial improvements in gas barrier, fire retardant, and antibacterial properties enable the materials for packaging application.

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Section: Resultsmentioning

confidence: 91%

Nano boron nitride laminated poly(ethyl methacrylate)/poly(vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging materials

Behera,

Patra,

Nazrul

et al. 2024

J of Applied Polymer Sci

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“…The coated maghemite nanoparticles show improved dispersibility, which leads to better stability [ 31 , 32 ]. The dextran used as a surfactant in this study protects the maghemite core against various oxidation incidents.…”

Section: Resultsmentioning

confidence: 99%

“…NPs’ stability is very important for biomedical applications to achieve the expected and consistent outcomes [ 31 , 40 , 41 ]. The low value of the zeta potential of MNPs implies that the NP can show poor stability in aqueous solutions [ 32 , 42 ]. In agreement with previous studies [ 41 , 42 ], low zeta potential values improve Van der Waals interparticle attractions and cause the rapid coagulation and flocculation of nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

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New Insights into the Biological Response Triggered by Dextran-Coated Maghemite Nanoparticles in Pancreatic Cancer Cells and Their Potential for Theranostic Applications

Balaș

Predoi

Burtéa

et al. 2023

IJMS

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Iron oxide nanoparticles are one of the most promising tools for theranostic applications of pancreatic cancer due to their unique physicochemical and magnetic properties making them suitable for both diagnosis and therapy. Thus, our study aimed to characterize the properties of dextran-coated iron oxide nanoparticles (DIO-NPs) of maghemite (γ-Fe2O3) type synthesized by co-precipitation and to investigate their effects (low-dose versus high-dose) on pancreatic cancer cells focusing on NP cellular uptake, MR contrast, and toxicological profile. This paper also addressed the modulation of heat shock proteins (HSPs) and p53 protein expression as well as the potential of DIO-NPs for theranostic purposes. DIO-NPs were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering analyses (DLS), and zeta potential. Pancreatic cancer cells (PANC-1 cell line) were exposed to different doses of dextran-coated ɣ-Fe2O3 NPs (14, 28, 42, 56 μg/mL) for up to 72 h. The results revealed that DIO-NPs with a hydrodynamic diameter of 16.3 nm produce a significant negative contrast using a 7 T MRI scanner correlated with dose-dependent cellular iron uptake and toxicity levels. We showed that DIO-NPs are biocompatible up to a concentration of 28 μg/mL (low-dose), while exposure to a concentration of 56 μg/mL (high-dose) caused a reduction in PANC-1 cell viability to 50% after 72 h by inducing reactive oxygen species (ROS) production, reduced glutathione (GSH) depletion, lipid peroxidation, enhancement of caspase-1 activity, and LDH release. An alteration in Hsp70 and Hsp90 protein expression was also observed. At low doses, these findings provide evidence that DIO-NPs could act as safe platforms in drug delivery, as well as antitumoral and imaging agents for theranostic uses in pancreatic cancer.

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“…Various modifications to the synthesis route have been implemented for obtaining MNPs helpful in biomedical applications. Synthesis of PEG integrated iron nanoparticles of size 33 ± 8 nm was done with the help of ultrasonic assisted co-precipitation technique [26]. MNPs prepared by co-precipitation method and directly coated with Oleic acid, SiO2 and PEG with average crystal size 6-7 nm, 10 nm and 10 nm respectively, show suitability for MRI application [27].…”

Section: Co-precipitation Methodsmentioning

confidence: 99%

Magnetic Nanoparticles for Drug Delivery Applications

Patel¹

2023

Magnetic Nanoparticles for Biomedical Applications

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Magnetic nanoparticles (MNPs) possess different structural, magnetic and dielectric properties compared to bulk magnetic particles and they have found potential applications in the biomedical field (due to their response to applied magnetic field) including MRI, targeted drug delivery, bio sensors, tissue engineering, cancer therapy, and diagnosis, biomaterial coating devices, hyperthermia, cell selection and separation, magnetorelaximetry, antibacterial agent, biomolecules extraction, immunoassay, lab-on-a-chip etc. The synthesis of MNPs can be done by various methods pertaining to the application one is interested in. In present chapter we discuss basic properties (surface and magnetic) of magnetic nano particles and their biomedical applications.

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Functionalized iron oxide nanoparticles: synthesis through ultrasonic-assisted co-precipitation and performance as hyperthermic agents for biomedical applications

Cited by 25 publications

References 42 publications

Nano boron nitride laminated poly(ethyl methacrylate)/poly(vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging materials

Nano boron nitride laminated poly(ethyl methacrylate)/poly(vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging materials

New Insights into the Biological Response Triggered by Dextran-Coated Maghemite Nanoparticles in Pancreatic Cancer Cells and Their Potential for Theranostic Applications

Magnetic Nanoparticles for Drug Delivery Applications

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