Magnetic field influence on electrical properties of human blood measured by impedance spectroscopy

Abstract

The impedance spectroscopy technique (IST) was used for studying the effect of a 0.5 T magnetic field on the electrical properties of whole human blood. A Solartron SI 1260 spectrometer was used to measure the impedance spectra of magnetic field exposed blood samples compared to non-exposed samples. An equivalent electrical circuit model, consisting in a resistance Rs in series with a parallel circuit formed by a constant phase element (CPE) and another resistance Rp, is proposed to fit the data in both cases. The experiment used 3 ml human blood samples from 160 healthy donors. A Wilcoxon matched pairs statistical test was applied to the data. The data analysis seems to show a statistically significant increase of the values of resistance Rp (Z = 5.06, P < 0.001) and capacitance CT (Z = 3.32, P < 0.001) of the blood exposed to magnetic field, by approximately 10.4% and 1.9%, respectively.

Magnetic Stimulation on Human Blood Electromotive force analysis

“…The literature has reported an increased blood resistance when it is exposed to static MF [6], in this work similar effect is shown using AMF.…”

“…Blood cells have also been studied, in particular, Higashi et al (1997) [5] studied the orientation of erythrocytes under a static MF of 8.0 T where a parallel orientation to the field lines was observed, authors suggested that this is due to magnetic features of the cell membrane. Later, M. Sosa et al (2005) [6] studied the changes in the electrical properties of the blood when it was exposed to a magnetic field of 0.5 T finding a resistance increase of 10.4 % and a 1.9 % in capacitance; given the highly non-conductive membrane properties, they were able to explain these * email: theo@dci.ugto.mx changes based on ion currents induced in the interstitial medium and the charge distribution generated in the membrane surface because of ions that remain attached to it. Other authors have studied sedimentation and aggregation behavior when the erythrocytes are in a MF of the order of 6.0 T [7].…”

Non-Thermal Radio Frequency and Static Magnetic Fields Increase Rate of Hemoglobin Deoxygenation in a Cell-Free Preparation

“…However, there may be other transduction pathways through which EMF signals could modulate tissue repair and growth. For example, several recent studies have reported EMF effects on human Hb in solution and erythrocyte suspensions, including decreases in viscosity [7] and changes in impedance [8], dielectric properties [9], dia- and para-magnetic properties [10], optical absorption [11] and in vivo deoxygenation [12]. In addition, radiofrequency mobile telephone signals have been shown to decrease Hb oxygen affinity in vitro [13] and changes in infrared absorption have been reported for low-frequency EMF [14].…”

Modeling and Simulation of Equivalent Circuits in Description of Biological Systems - A Fractional Calculus Approach

“…Electrical impedance spectroscopy (EIS) has proven useful in the characterization of biomaterials by recording the behavior of their intrinsic properties while evaluating the bioelectrical response of the system as a sinusoidal excitation signal is applied [9]. It has also been used to measure biological tissues in which the electrical impedance depends on water content and ionic conduction in the body.…”