Magnetic drug targeting: biokinetic study and therapeutic efficacy

Hulin, P.; Klein, Rachel; Schmidt, Andrew J.; Bergemann, Ch.; Parak, F.; Arnold, William R.

doi:10.1016/s0959-8049(01)80348-8

Cited by 57 publications

(77 citation statements)

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“…Ferrofluids respond to an external magnetic field and this enables to control the location of the ferrofluid through the application of a magnetic field. Ferrofluids have been tailor-made and possess a wide variety of potential applications in various industries [1][2][3][4][5]. Mechanical engineering industries use them as fluids in vibration dampers, shock absorbers, and vacuum seals.…”

Section: Introductionmentioning

confidence: 99%

Penetrative ferroconvection via internal heating in a saturated porous layer with constant heat flux at the lower boundary

Nanjundappa¹,

Shivakumara

Prakash

2012

Journal of Magnetism and Magnetic Materials

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a b s t r a c tA model for penetrative ferroconvection via internal heat generation in a ferrofluid saturated porous layer is explored. The Brinkman-Lapwood extended Darcy equation with fluid viscosity different from effective viscosity is used to describe the flow in the porous medium. The lower boundary of the porous layer is assumed to be rigid-paramagnetic and insulated to temperature perturbations, while at upper stress-free boundary a general convective-radiative exchange condition on perturbed temperature is imposed. The resulting eigenvalue problem is solved numerically using the Galerkin method. It is found that increasing in the dimensionless heat source strength N s , magnetic number M 1 Darcy number Da and the non-linearity of magnetization parameter M 3 is to hasten, while increase in the ratio of viscosities L, Biot number Bi and magnetic susceptibility w is to delay the onset of ferroconvection.Further, increase in Bi, Da À 1 and N s and decrease in L, M 1 and M 3 is to diminish the dimension of convection cells.

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Section: Introductionmentioning

confidence: 99%

Penetrative ferroconvection via internal heating in a saturated porous layer with constant heat flux at the lower boundary

Nanjundappa¹,

Shivakumara

Prakash

2012

Journal of Magnetism and Magnetic Materials

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“…Magnetic nanoparticles, especially iron oxide nanoparticles including magnetite Fe 3 O 4 and maghemite (γ-Fe 2 O 3 ) have been widely studied for their potential applications in a variety of biomedical fields for their unique physical, chemical and magnetic properties (Gupta and Gupta 2005;Berry and Curtis 2003). They are nontoxic, biocompatible (Perez et al 2002;Dyal et al 2003) and have been widely used in magnetic resonance imaging (MRI) contrast agents (Lee et al 2006;Babes et al 1999), hyperthermia therapy (Hergt et al 1998;Pardoe et al 2003;Sonvico et al 2005) and targeted drug delivery (Gupta and Wells 2004;Alexiou et al 2000;Jain et al 2005). Cowpea mosaic virus (CPMV) is one of the smallest plant viruses, which is an icosahedron with a spherical average diameter of 28.4 nm that built from 60 copies of two asymmetric protein units assembled around a single-stranded bipartite RNA genome (Lewis et al 2006;Blum et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells

Zhang

Yang

Portney

et al. 2007

Biomed Microdevices

372

215

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We demonstrate the use of surface Zeta potential measurements as a new tool to investigate the interactions of iron oxide nanoparticles and cowpea mosaic virus (CPMV) nanoparticles with human normal breast epithelial cells (MCF10A) and cancer breast epithelial cells (MCF7) respectively. A substantial understanding in the interaction of nanoparticles with normal and cancer cells in vitro will enable the capabilities of improving diagnostic and treatment methods in cancer research, such as imaging and targeted drug delivery. A theoretical Zeta potential model is first established to show the effects of binding process and internalization process during the nanoparticle uptake by cells and the possible trends of Zeta potential change is predicted for different cell endocytosis capacities. The corresponding changes of total surface charge of cells in the form of Zeta potential measurements were then reported after incubated respectively with iron oxide nanoparticles and CPMV nanoparticles. As observed, after MCF7 and MCF10A cells were incubated respectively with two types of nanoparticles, the significant differences in their surface charge change indicate the potential role of Zeta potential as a valuable biological signature in studying the cellular Biomed Microdevices

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“…6,7) A particular interest is placed on the superparamagnetic nano-ferroparticles (with a diameter < 10 nm) of magnetite (Fe 3 O 4 ) because of their high magnetic saturation, negligible toxicity, and easier surface modification. On application of a magnetic field, these particles carrying drug or gene can be targeted to a specific site and/or held in the tumour region.…”

Section: Introductionmentioning

confidence: 99%

Magnetorheological Behavior of Polyethyene Glycol-Coated Fe3O4 Ferrofluids

Qiao

Bai

Tao

et al. 2010

J. Soc. Rheol., Jpn

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Polyethyene glycol (PEG)-coated Fe 3 O 4 ferrofluids were prepared by suspending the PEG-coated Fe 3 O 4 nanoparticles in an oligomeric PEG-400 carrier liquid, and their magnetorheological steady flow behavior was investigated. The PEG modification did not change the crystalline structure of Fe 3 O 4 , and the PEG-coated Fe 3 O 4 nanoparticles were of nearly spherical shape and had a narrow size distribution (4±1 nm in diameter). These nanoparticles exhibited no significant aggregation in the absence of the magnetic field. Under the magnetic field, the nanoparticles aggregated into string-like clusters oriented in the direction of the field. Correspondingly, the ferrofluids behaved essentially as the Newtonian fluids in the absence of the magnetic field but exhibited, under the magnetic field, a magnetorheological effect, i.e., the increase of the shear stress/viscosity associated with a pseudo-plastic and thinning character with no real yield stress. This lack of the real yield stress, possibly reflecting the absence of huge clusters connecting the measuring parts (plates) in the rheometer, suggested that the magnetorheological effect of the ferrofluids were related to deformation/disruption of the magnetically formed clusters of finite sizes under the shear. Interestingly, this effect was most significant for the Fe 3 O 4 nanoparticles having an intermediate amount of PEG coating. This result suggested a possibility that the relaxation of PEG chains in the coating layers of nanoparticles in the clusters contributed to the magnetorheological effect.

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Magnetic drug targeting: biokinetic study and therapeutic efficacy

Cited by 57 publications

References 0 publications

Penetrative ferroconvection via internal heating in a saturated porous layer with constant heat flux at the lower boundary

Penetrative ferroconvection via internal heating in a saturated porous layer with constant heat flux at the lower boundary

Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells

Magnetorheological Behavior of Polyethyene Glycol-Coated Fe3O4 Ferrofluids

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