Magnetic droplet microfluidic system incorporated with acoustic excitation for mixing enhancement

Lee, Kang Yong; Park, Seungeun; Lee, Young Rang; Chung, Sang Kug

doi:10.1016/j.sna.2016.03.009

Cited by 41 publications

(17 citation statements)

References 49 publications

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“…Complex statistics needed to sort analysis data Difficult to perform long-term culture Droplet generation [188,189]; Mixing inside droplet [160,190]; Droplet-based microfluidic PCR [179];…”

Section: High-throughput Screening Systems: Microfluidic Devicesmentioning

confidence: 99%

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Riester

Borgolte

Csuk

et al. 2020

IJMS

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An aging population leads to increasing demand for sustained quality of life with the aid of novel implants. Patients expect fast healing and few complications after surgery. Increased biofunctionality and antimicrobial behavior of implants, in combination with supportive stem cell therapy, can meet these expectations. Recent research in the field of bone implants and the implementation of autologous mesenchymal stem cells in the treatment of bone defects is outlined and evaluated in this review. The article highlights several advantages, limitations and advances for metal-, ceramic- and polymer-based implants and discusses the future need for high-throughput screening systems used in the evaluation of novel developed materials and stem cell therapies. Automated cell culture systems, microarray assays or microfluidic devices are required to efficiently analyze the increasing number of new materials and stem cell-assisted therapies. Approaches described in the literature to improve biocompatibility, biofunctionality and stem cell differentiation efficiencies of implants range from the design of drug-laden nanoparticles to chemical modification and the selection of materials that mimic the natural tissue. Combining suitable implants with mesenchymal stem cell treatment promises to shorten healing time and increase treatment success. Most research studies focus on creating antibacterial materials or modifying implants with antibacterial coatings in order to address the increasing number of complications after surgeries that are mostly caused by bacterial infections. Moreover, treatment of multiresistant pathogens will pose even bigger challenges in hospitals in the future, according to the World Health Organization (WHO). These antibacterial materials will help to reduce infections after surgery and the number of antibiotic treatments that contribute to the emergence of new multiresistant pathogens, whilst the antibacterial implants will help reduce the amount of antibiotics used in clinical treatment.

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“…Complex statistics needed to sort analysis data Difficult to perform long-term culture Droplet generation [188,189]; Mixing inside droplet [160,190]; Droplet-based microfluidic PCR [179];…”

Section: High-throughput Screening Systems: Microfluidic Devicesmentioning

confidence: 99%

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Riester

Borgolte

Csuk

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…Several active droplet mixing techniques based on electrowetting on dielectric (EWOD) [7], bulk acoustic wave (BAW) [16], and surface acoustic wave (SAW) [17] have been proposed to address the above-mentioned limitations of the passive method. In the EWOD method, sessile droplets experience an AC electric field produced by planar electrodes for translocation, merging, and mixing [7].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Solutal Marangoni Flow Using Ultrasound-Induced Heating for Rapid Digital Microfluidic Mixing

et al. 2021

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Digital microfluidics based on sessile droplets has emerged as a promising technology for various applications including biochemical assays, clinical diagnostics, and drug screening. Digital microfluidic platforms provide an isolated microenvironment to prevent cross-contamination and require reduced sample volume. Despite these advantages, the droplet-based technology has the inherent limitation of the quiescent flow conditions at low Reynolds number, which causes mixing samples confined within the droplets to be challenging. Recently, solutal Marangoni flows induced by volatile liquids have been utilized for sessile droplet mixing to address the above-mentioned limitation. The volatile liquid vaporized near a sessile droplet induces a surface tension gradient throughout the droplet interface, leading to vortical flows inside a droplet. This Marangoni flow-based droplet mixing method does not require an external energy source and is easy to operate. However, this passive method requires a comparably long time of a few tens of seconds for complete mixing since it depends on the natural evaporation of the volatile liquid. Here, we propose an improved ultrasound-induced heating method based on a nature-inspired ultrasound-absorbing layer and apply it to enhance solutal Marangoni effect. The heater consists of an interdigital transducer deposited on a piezoelectric substrate and a silver nanowire-polydimethylsiloxane composite as an ultrasound-absorbing layer. When the transducer is electrically actuated, surface acoustic waves are produced and immediately absorbed in the composite layer by viscoelastic wave attenuation. The conversion from acoustic to thermal energy occurs, leading to rapid heating. The heating-mediated enhanced vaporization of a volatile liquid accelerates the solutal Marangoni flows and thus enables mixing high-viscosity droplets, which is unachievable by the passive solutal Marangoni effect. We theoretically and experimentally investigated the enhanced Marangoni flow and confirmed that rapid droplet mixing can be achieved within a few seconds. The proposed heater-embedded sessile droplet mixing platform can be fabricated in small size and easily integrated with other digital microfluidic platforms. Therefore, we expect that the proposed sample mixing method can be utilized for various applications in digital microfluidics and contribute to the advancements in the medical and biochemical fields.

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“…In a digital microfluidic system, chemical reaction rate, controlled by mixing of reagents, needs to be enhanced for faster operation and to accomplish multiple functions within few seconds . Therefore, several strategies have been explored to harness chaotic advection towards realizing homogeneous mixing in droplet‐based microfluidic applications, including electrowetting‐on‐dielectric , acoustic excitation , and magnetic stirring . However, most of the reported strategies perform the mixing process through the movement of the droplet, which inhibits on‐the‐spot mixing that may otherwise be absolutely essential for performing a desired biochemical or biomedical task (such as medical diagnostics), in situ .…”

Section: Introductionmentioning

confidence: 99%

“…Lee et al. reported a magnetic droplet microfluidic system where magnetic field was used to transport the droplet and acoustic excitation was used to induce oscillations in the droplet . Investigations were performed using droplets of methylene blue and glycerol (5 wt%) mixture.…”

Section: Introductionmentioning

confidence: 99%

Strong rotating flow in stationary droplets in low power budget using wire electrode configuration

2019

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We explore a simple strategy of generating strong rotating flow in a stationary surface‐droplet, using an intricate interplay of local electrical and thermal fields. Wire electrodes are employed to generate on‐spot heating without necessitating any elaborate micro‐fabrication, which causes strong local gradients in electrical properties to induce mobile charges into the droplet. Applying a low voltage (∼10 V), strong rotational velocity of the order of mm/s can be achieved in the system, within the standard operating ranges of operating and geometrical parameters. Further, altering the diameter of the electrode, vortices can be tuned locally or globally in low power budget, without incurring any droplet oscillations. These results may turn out to be of immense consequence in enhancing micromixing in a plethora of droplet based applications ranging from thermal management to medical diagnostics to be potentially employed in resource‐limited settings.

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Magnetic droplet microfluidic system incorporated with acoustic excitation for mixing enhancement

Cited by 41 publications

References 49 publications

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Enhanced Solutal Marangoni Flow Using Ultrasound-Induced Heating for Rapid Digital Microfluidic Mixing

Strong rotating flow in stationary droplets in low power budget using wire electrode configuration

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