Magnetic-driven wireless electrical stimulation in a scaffold

Qi, Fangwei; Gao, Xiuwen; Shuai, Yang; Peng, Shuping; Deng, Youwen; Yang, Sheng Lin; Yang, Youwen; Shuai, Cijun

doi:10.1016/j.compositesb.2022.109864

Cited by 40 publications

(25 citation statements)

References 56 publications

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“…The PLLA/ZIF-8@GO scaffolds were fabricated using an SLS system. , The mixed powder was prepared according to a predefined proportion, as shown in Table . The mixed powder was collected after ultrasonic stirring, high-speed centrifugation (7000 rpm, 10 min), and vacuum drying (60 °C, 12 h).…”

Section: Methodsmentioning

confidence: 99%

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

Yang

Zan

Shuai

et al. 2022

ACS Appl. Mater. Interfaces

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Bacterial infection with high morbidity (>30%) seriously affects the defect’s healing after bone transplantation. To this end, chemotherapy and photothermal therapy have been utilized for antibacterial treatment owing to their high selectivity and minimal toxicity. However, they also face several dilemmas. For example, bacterial biofilms prevented the penetration of antibacterial agents and local temperatures (over 70 °C) caused by the photothermal therapy damaged normal tissue. Herein, a co-dispersion nanosystem with chemo-photothermal function was constructed via the in situ growth of zeolitic imidazolate framework-8 (ZIF-8) on graphene oxide (GO) nanosheets. In this nanosystem, GO generates a local temperature (∼50 °C) to increase the permeability of a bacterial biofilm under near-infrared laser irradiation. Then, Zn ions released by ZIF-8 seized this chance to react with the bacterial membrane and inactivate it, thus realizing efficient sterilization in a low-temperature environment. This antibacterial system was incorporated into a poly-l-lactic acid scaffold for bone repair. Results showed that the scaffold showed a high antibacterial rate of 85% against both Escherichia coli and Staphylococcus aureus. In vitro cell tests showed that the scaffold promoted cell proliferation.

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Section: Methodsmentioning

confidence: 99%

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

Yang

Zan

Shuai

et al. 2022

ACS Appl. Mater. Interfaces

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“…Inorganic materials with excellent piezoelectric properties show wide applications in energy harvesting, actuators, and sensors, − yet poor biocompatibility limits utilization in bioengineering. Amino acid assemblies offer several advantages such as a minimalistic structure, easy functionalization, degradability, and low cost .…”

Section: Introductionmentioning

confidence: 99%

Modified Stranski–Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting

Yuan

Lin

et al. 2022

ACS Appl. Mater. Interfaces

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Biomolecule-based piezoelectric nanostructures emerged as a new class of energy-converse materials, and designing tailored piezoelectric amino acid arrays is essential to achieve efficient electrical–mechanical coupling and fulfill their application potential. However, the controlled growth of amino acid nanostructures is still challenging due to the limited understanding of their growth mechanism. Herein, we base on the Stranski–Krastanov (S–K) growth mode and propose a mechanism for the growth of ordered amino acid array structures via physical vapor deposition. The growth of vertical valine sheet arrays is examined by changing the substrate temperature, chamber pressure, and source–substrate distance, and a “layer-plus-sheet” growth process is revealed. The modified S–K growth mode is applied to fabricate other amino acid nanostructures like leucine and isoleucine. The growth mode not only explains the formation of uniform and controllable morphology of amino acid structures but also leads to the significant enhancement of their piezoelectric properties. The maximal effective piezoelectric constant of valine sheets is 11.4 pm V–1, which approaches its highest predicted value. The output voltage of the valine array-based nanogenerator is ∼4.6 times the output voltage of the valine powder-based nanogenerator. This work provides new insights into the growth mechanism of ordered piezoelectric amino acid arrays, making them promising candidates for applications in wearable or implantable electronic devices.

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“…The degradation of Mg alloys in vivo would release metal ions into the surrounding tissues, creating the risk of implant-related infections[ 58 - 60 ]. Therefore, it was essential to assess the cytotoxicity of the rare earth element Sc, which was added in Mg alloys.…”

Section: Resultsmentioning

confidence: 99%

Selective Laser Melted Rare Earth Magnesium Alloy with High Corrosion Resistance

Yang¹,

Ling²,

Yang³

et al. 2022

IJB

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Magnesium (Mg) degrades too fast in human body, which limits its orthopedic application. Single-phase Mg-based supersaturated solid solution is expected to possess high corrosion resistance. In this work, rare earth scandium (Sc) was used as alloying element to prepare Mg(Sc) solid solution powder by mechanical alloying (MA) and then shaped into implant using selective laser melting (SLM). MA utilizes powerful mechanical force to introduce numerous lattice defects, which promotes the dissolution of Sc in Mg matrix and forms supersaturated solid solution particles. Subsequently, SLM with fast heating and cooling rate maintains the original supersaturated solid solution structure. Immersion tests revealed that high Sc content significantly enhanced the corrosion resistance of Mg matrix because of the formation of protective corrosion product film, which was also proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg(Sc) alloy showed a relatively low degradation rate of 0.61 mm/year. In addition, cell tests showed that the Mg(Sc) exhibited favorable biocompatibility and was suitable for medical application.

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Magnetic-driven wireless electrical stimulation in a scaffold

Cited by 40 publications

References 56 publications

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

Modified Stranski–Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting

Selective Laser Melted Rare Earth Magnesium Alloy with High Corrosion Resistance

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