Magnetic delivery and ultrasound-responsive release of chelating microcapsules for selective removal of urolithiasis

Kaang, Byung Kwon; Lee, Sunjae; Piao, Junjie; Cho, Hyuk Jin; Kim, Dong-Pyo

doi:10.1039/d2lc01014c

Cited by 4 publications

(3 citation statements)

References 37 publications

(55 reference statements)

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“…7(c)), double emulsion templated microcapsules exhibited efficient delivery efficiency (>90%) and target delivered to specific urolithiasis sites for urolithiasis treatment. 185 Besides, Fe 3 O 4 nanoparticles could be incorporated into the capsule membrane for smart magnetic targeting. 188 An advantage of this approach is that the nanoparticles embedded in the capsule membranes did not diffuse out the membranes even after repeated swelling/shrinking 20 times.…”

Section: Smart Microcapsules For Target Deliverymentioning

confidence: 99%

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

Ren,

Liu,

Zhong

et al. 2024

Lab Chip

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Section: Smart Microcapsules For Target Deliverymentioning

confidence: 99%

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

Ren,

Liu,

Zhong

et al. 2024

Lab Chip

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“…Triggers include pH [ 32 , 56 , 68 , 83 ], temperature [ 54 , 66 , 76 , 80 , 83 , 84 ], osmotic pressure [ 25 , 59 , 81 ], hydrolysis [ 61 , 63 ], ultrasound [ 85 ], mechanical [ 60 , 81 ], photothermal [ 56 ], and photo switching mechanisms [ 86 ]. However, most research is confined to pH, temperature-, and osmotic-pressure-induced drug release.…”

Section: Compartmentalized Complex Emulsions For Multi-drug Deliverymentioning

confidence: 99%

“…Using nanoparticles can have further advantages beyond emulsion stability; they can be used as probes to locate the emulsions using MRI or ultrasound. Even more, they can be used to deliver and trigger drug release [ 85 ].…”

Section: Challenges and Possibilities In Designing Complex Emulsions-...mentioning

confidence: 99%

Complex Emulsions as an Innovative Pharmaceutical Dosage form in Addressing the Issues of Multi-Drug Therapy and Polypharmacy Challenges

Yandrapalli

2024

Pharmaceutics

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This review explores the intersection of microfluidic technology and complex emulsion development as a promising solution to the challenges of formulations in multi-drug therapy (MDT) and polypharmacy. The convergence of microfluidic technology and complex emulsion fabrication could herald a transformative era in multi-drug delivery systems, directly confronting the prevalent challenges of polypharmacy. Microfluidics, with its unparalleled precision in droplet formation, empowers the encapsulation of multiple drugs within singular emulsion particles. The ability to engineer emulsions with tailored properties—such as size, composition, and release kinetics—enables the creation of highly efficient drug delivery vehicles. Thus, this innovative approach not only simplifies medication regimens by significantly reducing the number of necessary doses but also minimizes the pill burden and associated treatment termination—issues associated with polypharmacy. It is important to bring forth the opportunities and challenges of this synergy between microfluidic-driven complex emulsions and multi-drug therapy poses. Together, they not only offer a sophisticated method for addressing the intricacies of delivering multiple drugs but also align with broader healthcare objectives of enhancing treatment outcomes, patient safety, and quality of life, underscoring the importance of dosage form innovations in tackling the multifaceted challenges of modern pharmacotherapy.

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Nanoparticle‐Empowered Core–Shell Microcapsules: From Architecture Design to Fabrication and Functions

Jiang,

Mu,

Zhou

et al. 2024

Small

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Compartmentalization is a powerful concept to integrate multiscale components with diverse functionalities into miniature architectures. Inspired by evolution‐optimized cell compartments, synthetic core–shell capsules enable storage of actives and on‐demand delivery of programmed functions, driving scientific progress across various fields including adaptive materials, sustainable electronics, soft robotics, and precision medicine. To simultaneously maximize structural stability and environmental sensitivity, which are the two most critical characteristics dictating performance, diverse nanoparticles are incorporated into microcapsules with a dense shell and a liquid core. Recent studies have revealed that these nano‐additives not only enhance the intrinsic properties of capsules including mechanical robustness, optical behaviors, and thermal conductivity, but also empower dynamic features such as triggered release, deformable structures, and fueled mobility. In this review, the physicochemical principles that govern nanoparticle assembly during microencapsulation are examined in detail and the architecture‐controlled functionalities are outlined. Through the analysis of how each primary method implants nanoparticles into microcapsules, their distinct spatial organizations within the core–shell structures are highlighted. Following a detailed discussion of the specialized functions enabled by specific nanoparticles, the vision of the required fundamental insights and experimental studies for this class of microcarriers to fulfill its potential are sketched.

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Magnetic delivery and ultrasound-responsive release of chelating microcapsules for selective removal of urolithiasis

Abstract: A novel urolithiasis treatment in which chelating solution encapsulated in poly(lactic-co-glycolic acid; PLGA)-based microcapsules was delivered magnetically to specific urolithiasis sites and then subjected to ultrasound (US) to release the...

Cited by 4 publications

References 37 publications

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

Complex Emulsions as an Innovative Pharmaceutical Dosage form in Addressing the Issues of Multi-Drug Therapy and Polypharmacy Challenges

Nanoparticle‐Empowered Core–Shell Microcapsules: From Architecture Design to Fabrication and Functions

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