Magnetic Cu/Fe3O4@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing

Huang, Yuanlin; Liang, Guangzhao; Lin, Tianran; Hou, Li; Ye, Fanggui; Zhao, Shulin

doi:10.1007/s00216-019-01841-y

Cited by 18 publications

(6 citation statements)

References 44 publications

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“…The detection limit is 0.01 μM. According to the previous reports (Table 1), the developed Pd−Pt@hemin‐rGO/CNTs‐COOH is superior to some nanocomposites with catalytic activity in wider linear range and lower detection limit [25–32] …”

Section: Resultsmentioning

confidence: 60%

“…According to the previous reports (Table 1), the developed PdÀ Pt@hemin-rGO/ CNTs-COOH is superior to some nanocomposites with catalytic activity in wider linear range and lower detection limit. [25][26][27][28][29][30][31][32] The specificity and selectivity were investigated through adding several potential interfering substances into the reaction system instead of H 2 O 2 , including metal ions, non-metal ions (10.0 mM of Fe 3 + , Cu 2 + , NO 3…”

Section: Peroxidase-like Activity Of Pd-pt@hemin-rgo/cnts-coohmentioning

confidence: 99%

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A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

Zhang

Shen

et al. 2023

ChemNanoMat

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Nanocomposite enzymes are attracting intensive attention worldwide. In the present study, a novel colorimetric H 2 O 2 paper sensor was developed based on a new type of nanocomposites composed of PdÀ Pt nanoparticles, hemin functionalized reduced graphene oxide (hemin-rGO) and carboxylated carbon nanotubes (CNTs-COOH). The proposed nanocomposites show a high peroxidase-like activity. It provides a sensitive platform showing a linear response toward H 2 O 2 in the range of 0.05-500 μM with a determination limit of 0.01 μM. Based on this, the composites were applied to construct a paper sensor for H 2 O 2 detection in real samples. The cost-effectiveness, simplicity and efficiency of this paper sensor could be developed for "point-of-care" analysis and other related areas.

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Section: Resultsmentioning

confidence: 60%

Section: Peroxidase-like Activity Of Pd-pt@hemin-rgo/cnts-coohmentioning

confidence: 99%

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

Zhang

Shen

et al. 2023

ChemNanoMat

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“…The EPR signal of . OH with typical peak intensity of 1 : 2 : 2 : 1 was observed in CuCo 2 S 4 NPs, and CuCo 2 S 4 NPs+H 2 O 2 system . Particularly, the generation of .…”

Section: Resultsmentioning

confidence: 93%

Bimetallic CuCo₂S₄ Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections

Guo

Ding

et al. 2020

ChemBioChem

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Peroxidase‐mimicking nanozymes that can generate toxic hydroxyl radicals (.OH) hold great promise as antibacterial alternatives. However, most of them display optimal performance under strongly acidic conditions (pH 3–4), and are thus not feasible for many medical uses, including burn infections with a wound pH close to neutral. Herein, we report a copper‐based nanozyme (CuCo2S4) that exhibits intrinsic peroxidase‐like activity and can convert H2O2 into .OH at neutral pH. In particular, bimetallic CuCo2S4 nanoparticles (NPs) exhibited enhanced peroxidase‐like activity and antibacterial capacity, superior to that of the corresponding monometallic CuS and CoS NPs. The CuCo2S4 nanozymes possessed excellent ability to kill various bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA). Furthermore, this CuCo2S4 nanozymes could effectively disrupt MRSA biofilms in vitro and accelerate MRSA‐infected burn healing in vivo. This work provides a new peroxidase mimic to combat bacteria in neutral pH milieu and this CuCo2S4 nanozyme could be a promising antibacterial agent for the treatment of burn infections.

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“…(3) Doping can increase the oxygen vacancies (OVs). OVs are formed in metal oxides or other oxygen-containing compounds in which the oxygen atoms (oxygen ions) in the lattice are detached by other elements (e.g., Cu [ 164 ], Gd [ 165 ], and Pt [ 166 ]) [ 155 , 167 ]. OV-rich NMs have abundant active sites and high surface energies, and can efficiently develop the catalytic activities of materials.…”

Section: Strategy To Enhance the Anti-redox Activity Of Nmsmentioning

confidence: 99%

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

et al. 2022

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Overproduced reactive oxygen and reactive nitrogen species (RONS) in the brain are involved in the pathogenesis of several neurological diseases, such as Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke, as they attack neurons and glial cells, triggering cellular redox stress. Neutralizing RONS, and, thus, alleviating redox stress, can slow down or stop the progression of neurological diseases. Currently, an increasing number of studies are applying nanomaterials (NMs) with anti-redox activity and exploring the potential mechanisms involved in redox stress-related neurological diseases. In this review, we summarize the anti-redox mechanisms of NMs, including mimicking natural oxidoreductase activity and inhibiting RONS generation at the source. In addition, we propose several strategies to enhance the anti-redox ability of NMs and highlight the challenges that need to be resolved in their application. In-depth knowledge of the mechanisms and potential application of NMs in alleviating redox stress will help in the exploration of the therapeutic potential of anti-redox stress NMs in neurological diseases. Graphical Abstract

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Magnetic Cu/Fe3O4@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing

Cited by 18 publications

References 44 publications

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

Bimetallic CuCo₂S₄ Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

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Magnetic Cu/Fe3O4@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing

Cited by 18 publications

References 44 publications

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H2O2

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H2O2

Bimetallic CuCo2S4 Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

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Product

Resources

About

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

A Colorimetric Paper Sensor Based on Self‐assembled Nanocomposite Pd−Pt@hemin‐rGO/CNTs‐COOH for the Detection of H₂O₂

Bimetallic CuCo₂S₄ Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections