Magnetic Control of Fe3O4 Nanomaterial for Fat Ablation in Microchannel

Chang, Ming; Chang, Ming-Yi; Lin, Wei-Siou; Gabayno, Jacque Lynn

doi:10.3390/ma8115429

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The results show that for the chosen parameters of the system the velocity, close to the drop edges, can achieve several centimeters per second . The characteristic value (10 -3 -10 -2 m/s) obtained in our simulations is three-to-four orders of magnitude larger than the value ≈ 3 × 10 −6 / reported in experiments of [9] with fat ablation by generated microcirculation flows of magnetic suspension. Nevertheless, we warrant the reader that theoretical velocity values obtained in the present paper are valid only at the very onset after the magnetic field application, and the temporal evolution of the speed caused by spreading of the ferrofluid cloud along the channel has to be checked in order to confirm the effectiveness of the proposed method during a few minutesa typical timescale for the medical intervention previewed for the brain stroke treatment by this method [1].…”

Section: Resultscontrasting

confidence: 69%

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To the theory of ferrohydrodynamic circulating flow induced by running magnetic field

Zubarev

Raboisson-Michel

Verger‐Dubois³

et al. 2020

Eur. Phys. J. Spec. Top.

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We present results of theoretical modelling of macroscopic circulating flow induced in a drop of ferrofluid by oscillating running magnetic field. The drop is placed in a narrow flat channel filled by a non-magnetic liquid. The aim of this work is development of a scientific basis for a progressive method of address drug delivery to thrombus clots in blood vessels with the help of the magnetically induced circulation flow. Our results show that the oscillating running field allows inducing the carrier fluid flow with velocity amplitude 1-10 cm/s. This is the range of values, presenting interest from the point of view of the drug delivery.

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Section: Resultscontrasting

confidence: 69%

“…) , Φ 0 = 0.05; = 1с (9) This means that we consider a cloud of ferroparticles with the typical length 1cm. Another important parameter intervening into calculations is the magnetic susceptibility of these particles.…”

Section: Resultsmentioning

confidence: 99%

To the theory of ferrohydrodynamic circulating flow induced by running magnetic field

Zubarev

Raboisson-Michel

Verger‐Dubois³

et al. 2020

Eur. Phys. J. Spec. Top.

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show abstract

“…In view of the above, this study abandoned the traditional and inconvenient method of polymer precipitating and centrifugation to treat proteins. This study combined magnetic controlled nanoparticle technology [ 22 , 23 ] by coating the magnetic nanoparticles with polyethylene glycol and utilized them by controlling the motion of the nanoparticles to capture protein in the serum. The captured protein impurities were later separated and removed to the bottom of the beaker using a permanent magnet instead of a precipitator in the traditional method.…”

Section: Introductionmentioning

confidence: 99%

Exosome purification based on PEG-coated Fe3O4 nanoparticles

Chang

Chao

et al. 2018

PLoS ONE

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Cancer cells secrete many exosomes, which facilitate metastasis and the later growth of cancer. For early cancer diagnosis, the detection of exosomes is a crucial step. Exosomes exist in biological fluid, such as blood, which contains various proteins. It is necessary to remove the proteins in the biological fluid to avoid test interference. This paper presented a novel method for exosome isolation using Fe3O4 magnetic nanoparticles (MNPs), which were synthesized using the chemical co-precipitation method and then coated with polyethylene glycol (PEG). The experimental results showed that the diameter of the PEG-coated Fe3O4 nanoparticles was about 20 nm, while an agglomerate of MNPs reached hundreds of nanometers in size. In the protein removal experiments, fetal bovine serum (FBS) was adopted as the analyte for bioassays of exosome purification. PEG-coated Fe3O4 MNPs reduced the protein concentration in FBS to 39.89% of the original solution. By observing a particle size distribution of 30~200 nm (the size range of various exosomes), the exosome concentrations were kept the same before and after purification. In the gel electrophoresis experiments, the bands of CD63 (~53 kDa) and CD9 (~22 kDa) revealed that exosomes existed in FBS as well as in the purified solution. However, the bands of the serum albumins (~66 kDa) and the various immunoglobulins (around 160 ~ 188 kDa) in the purified solution’s lane explained that most proteins in FBS were removed by PEG-coated Fe3O4 MNPs. When purifying exosomes from serum, protein removal is critical for further exosome investigation. The proposed technique provides a simple and effective method to remove proteins in the serum using the PEG-coated Fe3O4 MNPs.

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“…Finally, the materials were washed with deionized water until the pH value reached 7 and then the neutral materials were oven-dried at 70 °C for 24 h. The dried Ag/Fe 3 O 4 NPs were then ground into powder using an agate mortar. In addition, bare Fe 3 O 4 NPs were also prepared using a similar procedure without silver nitrate precursor [16]. …”

Section: Methodsmentioning

confidence: 99%

Antibacterial Effects of Magnetically-Controlled Ag/Fe3O4 Nanoparticles

et al. 2018

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This paper presents the use of a magnetic manipulation device to remotely control the movement of Ag/Fe3O4 nanoparticles (NPs) for enhancing the antibacterial effect of Ag particles in aqueous suspensions containing Escherichia coli (E. coli). The Ag/Fe3O4 magnetic NPs were prepared by co-precipitation method where the Ag particles are simultaneously synthesized with the Fe3O4 particles to form Ag and Fe3O4 nanocomposite materials. The manipulation system utilized a homogeneous rotating magnetic field to carry out magnetic stirring of NPs in the petri dishes containing bacterial suspensions. The optimum magnetron parameters and best antibacterial effects were implemented with six different concentrations from 0.6 wt % to 6.6 wt % of the NPs at driving frequencies from 50 rpm to 200 rpm for 3 min. The highest antibacterial effect of 99.4% was achieved at 5.4 wt % of NPs and the driving frequency of 100 rpm. A time-dependent antibacterial effect in 0.1 wt % of Ag/Fe3O4 was also observed. The results indicate that the use of specific rotating magnetic fields to manipulate Ag/Fe3O4 magnetic NPs can significantly improve the antibacterial efficacy. Due to the good biocompatibility of the Ag NPs, the presented technique can be applied to clean water resources in the future.

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Magnetic Control of Fe3O4 Nanomaterial for Fat Ablation in Microchannel

Cited by 6 publications

References 9 publications

To the theory of ferrohydrodynamic circulating flow induced by running magnetic field

To the theory of ferrohydrodynamic circulating flow induced by running magnetic field

Exosome purification based on PEG-coated Fe3O4 nanoparticles

Antibacterial Effects of Magnetically-Controlled Ag/Fe3O4 Nanoparticles

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