Magnetic conjugated polymer nanoparticles doped with a europium complex for biomedical imaging

Kemal, Evren; Peters, Ruby; Bourke, Struan; Fairclough, Simon M.; Bergstrom‐Mann, Patrick; Owen, Dylan M.; Sandiford, Lydia; Dailey, Lea Ann; Green, M.

doi:10.1039/c7pp00402h

Cited by 10 publications

(3 citation statements)

References 20 publications

(25 reference statements)

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“…The broad emission bands and the low emission lifetimes are disadvantages of polymeric systems for use in luminescence imaging. Coordination of Ln III in the polymer structure results in systems with narrow emission bands, and emission lifetime in the microsecond to millisecond range that is suitable for time-gated imaging [106][107][108][109][110][111]. Biocompatible polymers such as polysiloxanes, imidazole-based polymers, and polymeric sugar chains functionalized with Ln III are widely used in luminescence imaging [107][108][109].…”

Section: Nanoparticles and Polymers Systems Functionalized With Ln III Complexes In Bioimagingmentioning

confidence: 99%

Recent Advances in Luminescence Imaging of Biological Systems Using Lanthanide(III) Luminescent Complexes

Monteiro

2020

Molecules

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The use of luminescence in biological systems allows one to diagnose diseases and understand cellular processes. Molecular systems, particularly lanthanide(III) complexes, have emerged as an attractive system for application in cellular luminescence imaging due to their long emission lifetimes, high brightness, possibility of controlling the spectroscopic properties at the molecular level, and tailoring of the ligand structure that adds sensing and therapeutic capabilities. This review aims to provide a background in luminescence imaging and lanthanide spectroscopy and discuss selected examples from the recent literature on lanthanide(III) luminescent complexes in cellular luminescence imaging, published in the period 2016–2020. Finally, the challenges and future directions that are pointing for the development of compounds that are capable of executing multiple functions and the use of light in regions where tissues and cells have low absorption will be discussed.

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Section: Nanoparticles and Polymers Systems Functionalized With Ln III Complexes In Bioimagingmentioning

confidence: 99%

Recent Advances in Luminescence Imaging of Biological Systems Using Lanthanide(III) Luminescent Complexes

Monteiro

2020

Molecules

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“…Europium is a rare-earth lanthanide series element that is well-demonstrated for its applications in biology and medicine. It has been studied for various biomedical applications such as fluorescent labeling, metal ion detection, biomedical imaging, drug delivery, neurodegenerative disease therapy, and many more. Over the past decade, another promising application for which europium is well explored is pro-angiogenesis.…”

Section: Metal Nanoparticles For Angiogenesis Studymentioning

confidence: 99%

Recent Development of Metal Nanoparticles for Angiogenesis Study and Their Therapeutic Applications

Barui

Nethi

Haque

et al. 2019

ACS Appl. Bio Mater.

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Angiogenesis is a crucial biological process of development of blood vessels from pre-existing vasculature, which helps in several physiological functions including embryonic development, hair growth, ovulation, menstruation, tissue repair, and regeneration. Contrastingly, it is also imperative in various pathological conditions like cardiovascular/ischemic diseases, rheumatoid arthritis, cancers, ocular/retinal diseases, and others. These disease conditions are often treated by manipulating angiogenesis using different pro-angiogenic or antiangiogenic factors/molecules through either promoting or inhibiting this complex process, respectively. However, these conventional angiogenic treatment strategies fall short in attaining the desired therapeutic effect due to several limitations including low bioavailability, rapid clearance, high cost, nonspecificity, drug resistance and side effects. Therefore, it is high time for the advancement of different pro- and antiangiogenic materials that could overcome aforesaid limitations, followed by their effective use for the therapy of angiogenesis related diseases. Recently, nanotechnology has drastically advanced in various areas of biology and medicine including therapeutic angiogenesis. Globally, many research groups including ours explored various inorganic metal nanomaterials that could efficiently manipulate the angiogenesis process either by augmenting or inhibiting it. The extensive investigation of the mechanisms underlying nanomaterials-mediated manipulation of angiogenesis is also well-documented. In the present review article, we intend to introduce the recent developments of inorganic nanomedicine manipulating angiogenesis with major focus on pro-angiogenic nanomaterials and their therapeutic applications along with associated challenges and future directions.

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“…Over the past decades, a number of researchers focused on the design and synthesis of photofunctional hybrid materials which were based on lanthanide compounds given that they have a wide range of applications in areas such as chemical sensing, bio-imaging, and organic light-emitting devices (OLEDs) [1,2,3,4]. The combination of lanthanide compounds with variable matrices (silicon, carbon, zeolite, polymer, etc.)…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Ionogels Incorporated with Lanthanide (Eu3+, Tb3+) Complexes Covalently Modified Multi-Walled Carbon Nanotubes

2018

Polymers

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Ionogels refer to an emerging composite material made from the confinement of ionic liquids within some specific cross-linked network matrices. They have potential applications in areas such as electrochemical and optical-electric materials. Incorporation of lanthanide (Eu3+, Tb3+) complexes covalently functionalized multi-walled carbon nanotubes (MWCNTs) in ionogels provide new ideas to design and synthesize novel luminescent hybrid materials that have excellent characteristics of luminescence and ionic conductivity. Here, the multifunctional ionogels were synthesized by confining an ionic liquid and the rare earth functionalized MWCNTs in the cross-linked polymethyl methacrylate (PMMA) networks, resulting in a novel optical/electric multifunctional hybrid material. The SEM images and digital photographs suggest that the lanthanide functionalized MWCNTs are evenly dispersed in the hybrid matrices, thus leading to a certain transparency bulky gel. The resulting ionogels exhibit certain viscosity and flexibility, and display an intense red/green emission under UV-light irradiation. The intrinsic conductibility of the embedded ionic liquids and carbon nanotubes in conjunction with the outstanding photoluminescent properties of lanthanide complexes makes the soft hybrid gels a material with great potential and valuable application in the field of optical-electric materials.

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Magnetic conjugated polymer nanoparticles doped with a europium complex for biomedical imaging

Cited by 10 publications

References 20 publications

Recent Advances in Luminescence Imaging of Biological Systems Using Lanthanide(III) Luminescent Complexes

Recent Advances in Luminescence Imaging of Biological Systems Using Lanthanide(III) Luminescent Complexes

Recent Development of Metal Nanoparticles for Angiogenesis Study and Their Therapeutic Applications

Multifunctional Ionogels Incorporated with Lanthanide (Eu3+, Tb3+) Complexes Covalently Modified Multi-Walled Carbon Nanotubes

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