Magnetic and pH-responsive magnetic nanocarriers

Nawaz, Muhammad; Sliman, Yassine; Ercan, I.; Lima-Tenório, Michele K.; Tenório‐Neto, Ernandes T.; Kaewsaneha, Chariya; Elaı̈ssari, Abdelhamid

doi:10.1016/b978-0-08-101995-5.00002-7

Cited by 32 publications

(15 citation statements)

References 162 publications

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“…The structures of the magnetic polymer colloids preserved not only the magnetic properties of magnetic iron oxides but also other properties of organic molecules. The surface modification brings precise variation in the behavior of IONPs in solution such as the overall toxicity and pH response. , By tuning the size of the core, thickness of the coating, and target ligands, the nanoprobes were designed for targeting particular cells, tissues, and various disease biomarkers. The core/shell morphology of MNPs has the benefit of high stability against oxidation, good dispersibility, and a large surface area to load drugs onto the shell .…”

Section: Surface Functionalization and Modification Of Mnpsmentioning

confidence: 99%

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Khizar

Ahmad

Zine

et al. 2021

ACS Appl. Nano Mater.

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Over the past few years, engineered inorganic nanoparticles have been studied researched, and applied extensively in the biomedical field since resultant platforms increase the usage of the nanoparticles for particular theranostic applications. The innovation of such nanosystems has the potential to develop a theranostic mode that integrates both diagnosis and treatment of diseases in a particular system via combinatorial approaches of imaging, targeting, and therapy that accomplish the potential of personalized and tailored medicine. The manipulation of magnetic nanoparticles (MNPs) as theranostic agents have attained growing consideration in material science owing to their exclusive capability in magnetic targeting, magnetic resonance imaging, chemotherapy, hyperthermia, bioseparation, gene therapy, enzyme immobilization, and controlled release of the drug. To intensify the diagnostic and therapeutic efficacy, MNPs have been ornamented or functionalized with a range of materials to enhance the biocompatibility, stability, and capability to carry therapeutic payloads and to encapsulate imaging agents. Preferentially synthetic and natural polymers have been exploited to coat for ensuring their colloidal stability and good dispersibility in biological fluids. Stimuli-responsive polymers have also been used to functionalize MNPs to establish a therapeutic approach that can significantly enhance therapeutic effectiveness including the real-time monitoring in specific cells and tissues. The present review highlights the progress of MNPs emphasizing functionalization using diverse inorganic and organic and biomaterials. Furthermore, it also provides the soundproof concept on the potential of MNPs and their colloidal counterparts that offer attractive possibilities for theranostic applications. Finally, the main challenges and limitations in the use of MNPs for advanced biomedical applications have also been critically provided.

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Section: Surface Functionalization and Modification Of Mnpsmentioning

confidence: 99%

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Khizar

Ahmad

Zine

et al. 2021

ACS Appl. Nano Mater.

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“…In this process, two steps are involved: (i) a short burst of nucleation when the concentration of the precursor species reaches critical supersaturation and (ii) a subsequent slow growth of the nuclei by diffusion of the solutes to the surface on the crystal. [141] Ni-based electrocatalysts have been synthesized using this strategy. For example, NiFe nanocubes having an average side length of ∼320 nm were synthesized following a precipitation method, in which sodium citrate dihydrate acted as a chelating ligand to control the nucleation rate and crystal growth.…”

Section: Coprecipitation Synthesis Of Nickel-based Electrocatalystsmentioning

confidence: 99%

Nickel Based Electrocatalysts for Water Electrolysis

Angeles-Olvera¹,

Crespo‐Yapur²,

Rodríguez³

et al. 2022

Preprint

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Current hydrogen production is based on the reforming process leading to the emission of pollutants; therefore, a substitute production method is imminently required. Water electrolysis is an ideal alternative for large-scale hydrogen production, as it does not produce any carbon-based pollutant byproducts. Production of green hydrogen from water electrolysis using intermittent sources (e.g., solar, eolic) would facilitate clean energy storage. However, the electrocatalysts currently required for water electrolysis are noble metals, making this potential option expensive and inaccessible for industrial applications. Therefore, there is a need to develop electrocatalysts based on earth-abundant and low-cost metals. Nickel-based electrocatalysts are a fitting alternative because they are economically accessible. Extensive research has focused on developing nickel-based electrocatalysts for hydrogen and oxygen evolution. Theoretical and experimental work have addressed the elucidation of these electrochemical processes and the role of heteroatoms, structure, and morphology. Even though some works tend to be contradictory, they have lit up the path for efficient nickel-based electrocatalysts. For these reasons, herein, a review of recent progress is presented.

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“…Such gatekeepers could prevent or reduce drug leakage from the carrier before reaching it to the target site and prompt the drug release in response to the internal stimulus such as pH, 15 enzymes, 16 and redox 17 or external stimulus such as light, 18 magnetic field, 19 and ultrasound 20 at the target site. Moreover, to achieve better control on the releasing of drug from the carrier, dual‐stimuli responsive systems such as pH/light, 21 pH/magnetic field, 22 and temperature/magnetic field responsive 23 were designed. Poly(N‐isopropyl acrylamide) (PNIPAAm), is one of the most attractive temperature‐sensitive polymers, which could act as an effective gatekeeper on the surface of the MSNs 24 .…”

Section: Introductionmentioning

confidence: 99%

Design of thermosensitive polymer‐coated magnetic mesoporous silica nanocomposites with a core‐shell‐shell structure as a magnetic/temperature dual‐responsive drug delivery vehicle

Asgari

Soleymani

Miri

et al. 2021

Polymers for Advanced Techs

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A stimuli-responsive nanocomposite with a core-shell-shell structure consisting of iron oxide (Fe 3 O 4 ) nanoparticles as core, mesoporous silica as middle shell, and poly(Nisopropyl acrylamide-co-acrylic acid) (P[NIPAAm-co-AAc]) as an exterior shell with thermo-responsivity properties was synthesized to be used as a magnetic/temperature responsive drug delivery system. The structure, morphology, and size of P(NIPAAm-co-AAc)-coated mesoporous silica embedded magnetite nanoparticles (P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 ) were characterized by XRD, FTIR, and TEM analyses. Also, the heating ability of mesoporous silica-coated Fe 3 O 4 nanoparticles, and P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 nanocomposites was investigated under the exposure of an alternating magnetic field (AMF). The results indicated that the prepared nanocomposites could generate enough heat for hyperthermia applications. Moreover, the magnetic/temperatureresponsive drug release behavior of P(NIPAAm-co-AAc)@mSiO 2 @Fe 3 O 4 nanocomposites loaded with fluorouracil (5-FU) was studied under the exposure of the AMF (frequency = 120 kHz, and amplitude = 22 kA m À1 ), as well as two different temperatures (37 C and 45 C). The results showed that only 7.8% of the drug could be released after 20 h at 37 C (below the LCST of the copolymer). In contrast, by increasing the temperature of release medium up to 45 C (above the LCST of the copolymer), the amount of released drug was increased up to 47%. Moreover, by exposing the prepared nanocomposite to a safe AMF, a burst release of drug was observed, indicating the excellent responsivity of the carrier to an external magnetic field. These results proved that the obtained nanocomposite has a great performance to be used as a magnetic/temperature-sensitive drug carrier for advanced drug delivery applications.

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Magnetic and pH-responsive magnetic nanocarriers

Cited by 32 publications

References 162 publications

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Nickel Based Electrocatalysts for Water Electrolysis

Design of thermosensitive polymer‐coated magnetic mesoporous silica nanocomposites with a core‐shell‐shell structure as a magnetic/temperature dual‐responsive drug delivery vehicle

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