Magnesium VitB6 Intake Reduces Central Nervous System Hyperexcitability in Children

Abstract

This open study indicates that hyperexcitable children have low ERC-Mg with normal serum Mg(2+) values, and that Mg(2+)/vitamin B6 supplementation can restore normal ERC-Mg levels and improve their abnormal behavior.

Effectiveness of Methylphenidate Supplemented by Zinc, Calcium, and Magnesium for Treatment of ADHD Patients in the City of Zahedan

“…The essential role of zinc in protein and nucleic acid syntheses has also been proven (19)(20)(21). Magnesium plays a fundamental role in the energy-production conversion of ATP to ADP (22).…”

Magnesium in the Central Nervous System

“…Our results (Mousain--Bosc et al, 2004) showed a statistically significant improvement of the symptoms after Mg--B6 supplementation, together with a rise in Erc--Mg values. In this study, a slight but significant intra--erythrocyte Mg depletion was evident in ADHD patients together with a concomitant decrease in intracellular calcium concentrations.…”

“…Other studies from Kozielec et al, for the first time reported an intra--erythrocyte magnesium deficiency in ADHD children . We also published similar data (Mousain--Bosc et al, 2004. However, it is not a true "Mg deficiency" with clinically associated respiratory repletion, as is observed in familial hypomagnesaemia with secondary hypocalcemia (Shalev et al, 1998;Mousain--Bosc et al, 2004).…”

“…We also published similar data (Mousain--Bosc et al, 2004. However, it is not a true "Mg deficiency" with clinically associated respiratory repletion, as is observed in familial hypomagnesaemia with secondary hypocalcemia (Shalev et al, 1998;Mousain--Bosc et al, 2004). More precisely, it may be called "intracellular Mg deficiency" affecting mainly neural transmission, which is very sensitive to such ionic variations.…”

Proteomic analysis of magnesium-dependent proteins and children’s health

“…■ Неврологические роли магния осуществляются при участии иона Mg2+ в синаптической передаче сигнала с участием допамина, NMDA-рецепторов, в многочислен-ных сигнальных путях опосредования эффектов других нейротрансмиттеров (сигнальных G(s)-, G(i)-и G(z)-белков, ионов кальция, фосфолипазы С, которые участвуют в осу-ществлении эффектов катехоламинов, серотонина, до-памина и др.). Нарушение активности этих белков будет приводить к дефициту внимания и гиперактивности, ко-морбидных дефициту магния [4,[15][16][17]. При этом при де-фиците витамина В6 будет наблюдаться дефицит нейро-трансмиттеров, который проявится у детей в задержке развития, у детей и взрослых -в дисфункции перифери-ческой нервной системы, гипотония и гипокинезия [18].…”