Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

Wei, Xiao-Gang; Zhou, Wenhao; Tang, Zhi; Wu, Hao; Liu, Yichao; Dong, Hongyan; Wang, Ning; Huang, Hongyan; Bao, Shusen; Shi, Lei; Li, Xiaokang; Zheng, Yufeng; Guo, Zheng

doi:10.1016/j.bioactmat.2022.05.011

Cited by 58 publications

(45 citation statements)

References 57 publications

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“…Moreover, most bioactive materials are encapsulated in PEEK matrices and the surface bioactivity of these composites is still low. Researchers often modify the surface of PEEK composites to improve their surface bioactivity through roughening treatments [ 17 ] and the introduction of chemical groups [ 18 ] and coatings [ 156 ]. Among them, biomolecular modifications such as the extracellular matrix (ECM), growth factors (GFs), bioactive peptides, plant extracts, and antibiotics [ 52 ] can enhance the antimicrobial properties and osteogenic activity of PEEK and its composites.…”

Section: Adhesive Properties Of Peek In Dental Applicationsmentioning

confidence: 99%

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

et al. 2023

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Polyetheretherketone (PEEK) is a thermoplastic material widely used in engineering applications due to its good biomechanical properties and high temperature stability. Compared to traditional metal and ceramic dental materials, PEEK dental implants exhibit less stress shielding, thus better matching the mechanical properties of bone. As a promising medical material, PEEK can be used as implant abutments, removable and fixed prostheses, and maxillofacial prostheses. It can be blended with materials such as fibers and ceramics to improve its mechanical strength for better clinical dental applications. Compared to conventional pressed and CAD/CAM milling fabrication, 3D-printed PEEK exhibits excellent flexural and tensile strength and parameters such as printing temperature and speed can affect its mechanical properties. However, the bioinert nature of PEEK can make adhesive bonding difficult. The bond strength can be improved by roughening or introducing functional groups on the PEEK surface by sandblasting, acid etching, plasma treatment, laser treatment, and adhesive systems. This paper provides a comprehensive overview of the research progress on the mechanical properties of PEEK for dental applications in the context of specific applications, composites, and their preparation processes. In addition, the research on the adhesive properties of PEEK over the past few years is highlighted. Thus, this review aims to build a conceptual and practical toolkit for the study of the mechanical and adhesive properties of PEEK materials. More importantly, it provides a rationale and a general new basis for the application of PEEK in the dental field.

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Section: Adhesive Properties Of Peek In Dental Applicationsmentioning

confidence: 99%

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

et al. 2023

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“…At the same time, magnesium ions released by the graft promoted angiogenesis. Rabbit femur implantation experiments also showed that modified PEEK significantly promoted osseointegration [ 172 ].…”

Section: Osteogenic Activitymentioning

confidence: 99%

“… [ 161 ] CF In vitro : the density of cells was higher in the group without polishing and sandblasting; no cytotoxicity. [ 164 ] Magnesium ion, PDA In vitro : promoted the proliferation, adhesion, and differentiation of MC3T3-E1 cells In vivo : promoted osseointegration of rabbit femur [ 172 ] PEEK nano-composites MoS 2 , In vitro : increased cytocompatibility; improved surface roughness and hydrophilicity. [ 175 ] NBG, HK In vitro : higher cytocompatibility and differentiation in mBPC and dmBPC group; good antibacterial activity in mBPC; In vivo : induced greater bone formation of rabbit femur in mBPC and dmBPC group.…”

Section: Introductionmentioning

confidence: 99%

Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Zheng

Liu

Zhang

et al. 2022

Materials Today Bio

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“…In addition, these functional groups can be used to chelate metal ions and control the release of ions. 27,34,35 Therefore, the surface of bone tissue engineering materials can be modified with PDA to release Sr 2+ in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

“…Dopamine (DA) can form coatings on almost any solid material, thus changing the surface properties of the material . In alkaline ambient solutions, DA oxidizes and self-polymerizes to synthesize polydopamine (PDA), which adheres to the surface of various materials or substances, such as metals, hydrogels, and polymers, through covalent bonds and hydrogen bonds. − Due to the existence of amino and catechol functional groups, the biological activity of the material surface is greatly increased. In addition, these functional groups can be used to chelate metal ions and control the release of ions. ,, Therefore, the surface of bone tissue engineering materials can be modified with PDA to release Sr 2+ in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

Strontium Ion-Functionalized Nano-Hydroxyapatite/Chitosan Composite Microspheres Promote Osteogenesis and Angiogenesis for Bone Regeneration

Cheng

Ding

Jin

et al. 2023

ACS Appl. Mater. Interfaces

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Critical-size bone defects are an important problem in clinical practice, which usually occurs in severe trauma, or tumor resection, and cannot heal completely and autonomously. Implantation of grafts is often required to promote the regeneration of critical-size bone defects. Metal ions play an important role in human health, as they affect the body's metabolism and the tissue function. Strontium ions (Sr 2+ ) can promote osteogenesis and angiogenesis. Herein, we prepared nano-hydroxyapatite (nHA)/ chitosan (CS) composite microspheres with a uniform particle size distribution and an extracellular matrix-like nanofiber structure using microfluidic technology and direct alkali-induced gelation. Strontium ions were stably added into the microspheres by using polydopamine (PDA) to chelate metal ions forming a bone repair material (nHA/CS@PDA-Sr) with good bioactivity. The coordination reaction of PDA can effectively control the release of strontium ions and avoid the negative effects caused by the high strontium concentration. Our in vitro experiments showed that the composite microspheres had good biocompatibility and that the PDA coating promotes cell adhesion. The slow release of strontium ions can effectively promote mesenchymal stem cells osteogenic differentiation and the vascularization of endothelial cells. In addition, we injected composite microspheres into cranial defects of rats to evaluate osseointegration in vivo. The results showed that nHA/CS@PDA-Sr could effectively promote bone regeneration in the defect area. This study demonstrates that composite microspheres stimulate bone repair providing a promising way for bone-defect regeneration.

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Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

Cited by 58 publications

References 57 publications

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

PEEK for Oral Applications: Recent Advances in Mechanical and Adhesive Properties

Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Strontium Ion-Functionalized Nano-Hydroxyapatite/Chitosan Composite Microspheres Promote Osteogenesis and Angiogenesis for Bone Regeneration

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