Magnesium Sulfate Treatment Decreases N-Methyl-D-Aspartate Receptor Binding in the Rat Brain: An Autoradiographic Study

Hallak, Mordechai; Berman, Robert F.; Irtenkauf, Susan M.; Janusz, Cynthia A.; Cotton, David B.

doi:10.1177/107155769400100106

Cited by 41 publications

(15 citation statements)

References 21 publications

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“…23 Similarly, MG significantly reduced NMDA receptor binding capacity in the rat brain. 24 Burd et al. studied the short term effect of MG using a model of LPS induced preterm birth in mice.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Magnesium sulfate prevents maternal inflammation–induced impairment of learning ability and memory in rat offspring

Lamhot

Khatib

Ginsberg

et al. 2015

American Journal of Obstetrics and Gynecology

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Section: A N U S C R I P Tmentioning

confidence: 99%

Magnesium sulfate prevents maternal inflammation–induced impairment of learning ability and memory in rat offspring

Lamhot

Khatib

Ginsberg

et al. 2015

American Journal of Obstetrics and Gynecology

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“…In rats, systemic magnesium treatment results in a resistance to both electrically stimulated81 and NMDA-induced hippocampal seizures82. In addition, systemic treatment with MgSO 4 causes a significant reduction in the NMDA receptor binding capacity in the brain78. Animal studies have also shown that MgSO 4 reduces epileptic seizure activity83, though these findings have been challenged due to inadequate controls76.…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Magnesium Sulfate for the Treatment of Eclampsia

Euser

Cipolla

2009

Stroke

272

203

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Background and Purpose-Magnesium sulfate is used extensively for prevention of eclamptic seizures. Empirical and clinical evidence supports the effectiveness of magnesium sulfate; however, questions remain as to its safety and mechanism. This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment. Summary of Review-Several mechanisms are presented, including the effects of magnesium sulfate on peripheral and cerebral vasodilation, blood-brain barrier protection, and as an anticonvulsant. Conclusions-Though the specific mechanisms of action remain unclear, the effect of magnesium sulfate in the prevention of eclampsia is likely multi-factorial. Magnesium sulfate may act as a vasodilator, with actions in the peripheral vasculature or the cerebrovasculature, to decrease peripheral vascular resistance or relieve vasoconstriction. Additionally, magnesium sulfate may also protect the blood-brain barrier and limit cerebral edema formation, or it may act through a central anticonvulsant action.

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“…Lastly, MgSO 4 is an NMDA receptor antagonist and thus would act as an anti-convulsant if it were in high enough concentration in the brain. 117 …”

Section: Management Of Eclampsiamentioning

confidence: 99%

Seizures in Women With Preeclampsia: Mechanisms and Management

Cipolla

Kraig

2011

Fet. Matern. Med. Rev.

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Eclampsia is defined in the obstetrical literature as the occurrence of unexplained seizure during pregnancy in a woman with preeclampsia. In the Western world, the incidence of eclampsia is ~1 per 2000 to 1 per 3000 pregnancies, but the incidence is 10-fold higher in tertiary referral centers and undeveloped countries where there is poor prenatal care, and in multi-fetal gestations. Nearly 1 in 50 women with eclampsia die as do 1 in 14 of their offspring, and mortality rates are considerably higher in undeveloped countries. Eclampsia is also associated with significant life-threatening complications, including neurological events. Seizure acutely can cause stroke, haemorrhage, oedema and brain herniation and thus lead to epilepsy and cognitive impairment later in life.

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Magnesium Sulfate Treatment Decreases N-Methyl-D-Aspartate Receptor Binding in the Rat Brain: An Autoradiographic Study

Cited by 41 publications

References 21 publications

Magnesium sulfate prevents maternal inflammation–induced impairment of learning ability and memory in rat offspring

Magnesium sulfate prevents maternal inflammation–induced impairment of learning ability and memory in rat offspring

Magnesium Sulfate for the Treatment of Eclampsia

Seizures in Women With Preeclampsia: Mechanisms and Management

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