Magnesium sulfate for postoperative complications in children undergoing tonsillectomies: a systematic review and meta‐analysis

Abstract

Unlike the studies in adults, this review shows there is no statistically significant effect of perioperative use of magnesium in the postoperative pain control in children undergoing tonsillectomies. But it seems has benefits in reducing rescue analgesia, emergence agitation incidence, and laryngospasm.

Comparative evaluation of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia: a meta-analysis of randomized controlled trials

“…Although a previous systematic review found that intravenous administration of magnesium sulfate in orthopedic surgery could reduce postoperative requirement for postoperative analgesics and adverse events such as vomiting, nausea, and shivering [24], the role of intravenous magnesium sulfate was controversial. Some studies had found that intravenous magnesium failed to improve postoperative pain in gastrointestinal surgery [25] and in a pediatric population undergoing tonsillectomy [26]. The reason may be the limited ability of magnesium ions to penetrate the blood-brain barrier [27], so it seems plausible that epidural or intrathecia magnesium might be more effective.…”

Role of magnesium sulfate in the treatment of acute postoperative pain

“…Postoje dokazi, mada ograničeni, da perioperativno primenjen paracetamol, nesteroidni antiinflamatorni lekovi, deksametazon, ketamin, klonidin i deksmedetomidin mogu umanjiti postoperativni bol i potrošnju opioida u nekim populacijama pedijatrijskih hirurških bolesnika (71). Nedavno je sprovedena metaanaliza deset randomizovanih kontrolisanih studija (sa ukupno 665 učesnika) koje su ispitivale uticaj intravenski primenjenog magnezijum-sulfata na postoperativne komplikacije kod dece koja su podvrgnuta tonzilektomiji (72). Za razliku od odraslih, kod dece nije nađen statistički značajan analgetički efekat perioperativne upotrebe ovog leka u postoperativnoj kontroli bola.…”

The efficacy of intravenous magnesium sulfate versus intravenous paracetamol on children posttonsillectomy pain and analgesic requirement: A randomized controlled study

“…Tonsillectomy is commonly associated with morbidity as postoperative pain nausea, vomiting, bleeding, and dehydration. [ 1 ] Postoperative pain control after the tonsillectomy has a very important role in recovery time, hospitalization duration, hemodynamic effects, bleeding, nausea, vomiting, and financial costs. [ 2 ] On the other hand, most patients undergoing this surgery are children that have lower pain thresholds and experience restlessness early, having negative psychological effects on them and their family.…”

“…[ 2 ] On the other hand, most patients undergoing this surgery are children that have lower pain thresholds and experience restlessness early, having negative psychological effects on them and their family. [ 1 ] At the beginning of the last century, the role of magnesium sulfate in postoperative pain and opioid consumption has been studied. However, results of those studies are variable.…”

“…[ 8 ] In many kinds of research, different drugs as opioids, NSAIDs, steroids, and paracetamol have been studied to decrease that pain. [ 1 ] NSAIDs are commonly used for analgesia after tonsillectomy; although, their usage is controversial because of the increased risk of platelet adhesion disorder leading to postoperative bleeding. [ 9 ]…”