Magnesium Metabolism in Hyperparathyroidism and Osteolytic Disease*

Eliel, Leonard P.; Smith, William O.; Chanes, Raul E.; Hawrylko, Josephine

doi:10.1111/j.1749-6632.1969.tb13012.x

Cited by 19 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the hypocalcaemic animals high serum concentrations and normal Mg concentrations may have favoured incorporation of Mg in bone. Increased skeletal concentrations of Mg in PTX rats fed adequate amounts of Mg have also been reported by Heaton (1965), Gitelman et al (1968) and Eliei, Smith, Chañes & Hawrylko, 1969. …”

Section: Discussionsupporting

confidence: 50%

Effects of Parathyroidectomy on the Development of Nephrocalcinosis and Calcium, Phosphorus and Magnesium Balance in Rats

Goulding¹,

Malthus²

1971

Journal of Endocrinology

View full text Add to dashboard Cite

Rats of different strains raised on a semipurified casein\p=m-\sugar diet, develop a nephrocalcinosis in which deposits composed principally of calcium and phosphorus accumulate at the corticomedullary junction of the kidney. To determine whether the development of this nephrocalcinosis was in any way related to the activity of the parathyroid glands, female weanling 21-day-old rats were parathyroidectomized (PTX) or sham\x=req-\ operated and fed the semipurified diet for 3 weeks. Absorption, retention and excretion of Ca, P and Mg were studied during a 14-day balance period. The effects of injecting PTX rats with a small amount of parathyroid extract (15 U.S.P. units Lilly Para-thor-mone, every 12 h for 1 week) were examined.Compared with sham-operated animals PTX rats showed: lower serum Ca and higher P concentrations; a lower urinary excretion (% intake) of Ca, P and Mg; a higher retention (% intake) of P and Mg; a higher concentration of Mg in bone (% femur ash). Administration of parathyroid extract (PTE) tended to reverse changes induced by parathyroidectomy but PTE-treated animals remained slightly hypocalcaemic. Sham-operated and PTE-treated PTX rats developed nephrocalcinosis but untreated PTX rats did not do so.The results indicate that nephrocalcinosis did not develop in rats fed the semipurified diet in the absence of parathyroid hormone. It is postulated that although some activity of the parathyroid glands is needed for mineral deposition in the renal tubules, excessive activity is not necessarily a prerequisite to the development of this type of renal calcification.

show abstract

Section: Discussionsupporting

confidence: 50%

Effects of Parathyroidectomy on the Development of Nephrocalcinosis and Calcium, Phosphorus and Magnesium Balance in Rats

Goulding¹,

Malthus²

1971

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Finally, some experimental data suggest a common transport system for Mg and Ca (5-7), while other results do not (8,9). Regardless of whether Ca and Mg share a common transport system, vitamin D (10,11) and parathyroid hormone (12) stimulate Mg as well as Ca absorption.…”

Section: Introductionmentioning

confidence: 99%

Magnesium absorption in the human small intestine. Results in normal subjects, patients with chronic renal disease, and patients with absorptive hypercalciuria.

Brannan¹,

Vergne-Marini²,

Pak³

et al. 1976

J. Clin. Invest.

152

View full text Add to dashboard Cite

“…In patients with primary hyperparathyroidism there is a negative magnesium balance, possibly due to the increased filtered load of calcium interfering with the resorption of magnesium [H a nn a et al, 1961]. It seems that the intestinal absorption of magnesium is mainly controlled by parathyroid hormone mechanisms [M a c Intyre and R o b inson, 1969] and there is some evidence that parathyroid hormone influences the transport of magnesium in the intestine and kidney through a mechanism distinct from that for calcium [Eliel et al, 1969]. In turn, it seems that the magnesium has a calcium-like effect on the rate of parathyroid secretion [Care et al, 1966;Buckle et al, 1968;Sherw o o d et al, 1969Sherw o o d et al, , 1970; this has led some to justify the use of high magnesium dialysate concentrations to suppress the hyperparathyroidism of patients on regular dialysis treatment (RDT) [Pletka et al, 1971], although the consequences of this will be challenged later.…”

Section: The Particular Problems O F Magnesium Handling In Chronic Rementioning

confidence: 99%

Divalent Ion Metabolism and the Kidney

Parsons

1973

Nephron

View full text Add to dashboard Cite

This review has dealt with some aspects of the growing points in divalent ion metabolism in renal disease and its treatment. Further advances will only be made when the exact mechanisms of the uraemic toxic state and its action on the variety of cellular membrane and intracellular metabolic functions has been elucidated. The interaction of hormones and these toxins are beginning to be looked at in the isolated cellular systems and many clinical observations remain to be worked out at this level.

show abstract

Magnesium Metabolism in Hyperparathyroidism and Osteolytic Disease*

Cited by 19 publications

References 28 publications

Effects of Parathyroidectomy on the Development of Nephrocalcinosis and Calcium, Phosphorus and Magnesium Balance in Rats

Effects of Parathyroidectomy on the Development of Nephrocalcinosis and Calcium, Phosphorus and Magnesium Balance in Rats

Magnesium absorption in the human small intestine. Results in normal subjects, patients with chronic renal disease, and patients with absorptive hypercalciuria.

Divalent Ion Metabolism and the Kidney

Contact Info

Product

Resources

About