Magnesium Metabolism in College Women: Observations on the Effect of Calcium and Phosphorus Intake Levels

Leichsenring, Jane M.; Norris, Loana M.; Lamison, Sara A.

doi:10.1093/jn/45.4.477

Cited by 32 publications

(9 citation statements)

References 10 publications

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“…Their serum Mg levels were slightly lower (0.58 and 0.57 mmol/l in the mother and 0.58 and 0.63 mmol/l in the father). Urinary Mg excretion (2.29 and 2.13 mmol/day, respectively) was also slightly reduced (NR for adults 2.5-5.8 mmol/day) (12,13). Administration of Mg Laspartate by mouth (30 mEq/day) for 3 days led to small increases in serum Mg (0.69 and 0.74 mmol/l, respectively) without changing significantly daily Mg urinary excretion (2.2 and 3.1 mmol/day).…”

Section: Case Reportmentioning

confidence: 94%

Primary idiopathic hypomagnesemia in two female siblings

et al. 1995

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Two female siblings with primary idiopathic hypomagnesemia, born to consanguineous parents, are described. Both presented at 6 weeks of age, with convulsions and persistent hypocalcemia (calcium 1.5 adn 1.6 mmol/l; normal range (NR) 2.2-2.6 mmol/l), which could not be controlled with anticonvulsants and/or calcium gluconate. On further investigation they were also found to have hypomagnesemia (magnesium 0.17 mmol/l and 0.22 mmol/l; NR 0.65-1.05 mmol/l). Convulsions and the low serum calcium and magnesium levels were first managed by im and then by oral administration of magnesium supplements. A burst in circulating parathyroid hormone levels to well above the physiological range was observed at the start of therapy. Serum magnesium values of the mother and father were just below the normal range, with normal serum calcium. This type of infantile primary hypomagnesemia appears to be a hereditary disease with autosomal recessive characteristics, although a partially penetrant X-linked or autosomal dominant trait cannot be excluded.

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Section: Case Reportmentioning

confidence: 94%

Primary idiopathic hypomagnesemia in two female siblings

et al. 1995

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“…Mg absorption in healthy human subjects given a mixed diet low in protein and moderately low in Ca and supplemented with vegetables has been shown to be improved when protein replaced an equi-caloric amount of sugar or fat (McCance, Widdowson & Lehmann, 1942). The effect of increased dietary Ca is less clear; thus De & Basu (1949) found that it impaired Mg absorption, but no definite effect is apparent from the results of Leichsenring, Norris & Lamison (1951) either with increased dietary Ca alone, or with increased Ca and phosphate.…”

mentioning

confidence: 99%

The effect of certain dietary factors on the apparent absorption of magnesium by the rat

Toothill¹

1963

Br J Nutr

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Numerous workers have established a connexion between the metabolism of magnesium and various dietary factors. Thus Colby & Frye (1951 b) working with young rats on a low-Mg, low-calcium diet observed reduction in blood Mg levels and increase in mortality rate when the casein content of the diet was increased from 24 to 50 yo. , 1961). Thus, although it is evident that Ca and phosphate impair Mg absorption in certain animals, the relative and combined effects of these two factors have not been studied to any great extent.Mg absorption in healthy human subjects given a mixed diet low in protein and moderately low in Ca and supplemented with vegetables has been shown to be improved when protein replaced an equi-caloric amount of sugar or fat (McCance, Widdowson & Lehmann, 1942 (1955, 1957) have suggested that the high levels of ammonia that occur in the rumen of cows grazing spring grass may interfere with Mg absorption from the small intestine or may reflect a reduction in the concentration there of amino acids, which could also result in poorer absorption.In the experiments now reported the effect was studied of protein level, ammonium salts, Ca carbonate and sodium orthophosphate on the apparent absorption of Mg. The main object was to study factors affecting the absorption of Mg, and retention was determined in only one experiment. Rats were given diets containing about 20 mg Mg/Ioo g diet, a level reported adequate for growth and maintenance of normal levels of blood 1Mg in young rats (Kunkel & Pearson, 1948). Diets and general techniqueThe composition of, and content of some inorganic constituents in, the low-Mg basal diets and the experimental diets are given in Tables I and 2. Male hooded Norwegian rats were housed individually in metabolic cages of the Hopkins type (Ackroyd & Hopkins, 1916) and fed to appetite. Diets were moistened with distilled water to prevent scattering. I n addition, a vitamin mixture was given by pipette that provided a weekly dose of 1.4 mg DL-a-tocopherol, 360 i.u. vitamin A and 26 i.u. vitamin D. Distilled water was given in glass bulbs. Faeces and urines were collected daily and, at the end of the collection period, the separator, urine container and glass funnel were rinsed with hot, about o -~N -H C~, and the rinsings added to the urine. JOYCE TOOTHILL I963Ca was precipitated as the oxalate at pH 4-5 (Smith, 1957) and the tube and precipitate were washed once with about I ml distilled water; sodium citrate was used to prevent the co-precipitation of iron during the precipitation of the ammonium magnesium phosphate, and the 33 % (v/v) ammonia solution quoted by Godden (1937, p. 40) for washing the Mg precipitate was replaced by one of 10 yo (vfv) strength. Two precipitations of the Mg were found necessary for satisfactory results. The precipitate was finally dissolved in a small volume of about 2~-H h T 0~, the solution transferred to a volumetric flask and P determined as above. In order to check for manganese contamination, additional ammonium magnesium phosphate prec...

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“…The magnesium balance studies reported in this paper provide suggestive, but not conclusive, evidence in favor of a considerable revision downward of the magnesium requirements generally postulated for adult maintenance (4,23,(26)(27)(28)30). If the conserving mechanisms noted to be effective in these studies over a 10 day period were assumed to be permanent, an intake of less than 1 mEq.…”

Section: Discussionmentioning

confidence: 56%

“…The interpretation of previous magnesium balance studies (4,(22)(23)(24)(25)(26) has been obscured by large intakes which make it difficult, if not impossible, to evaluate small positive or negative balances. These and other reports (27,28) are not in agreement in defining the requirements of healthy adults, and consequently, it is necessary to establish the efficiency of the conserving mechanisms present in the body as a clue to the daily magnesium requirements.…”

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confidence: 99%