Magnesium ions and opioid agonists in vincristine-induced neuropathy

Bujalska, Magdalena; Makulska-Nowak, Helena E.; Gumulka, S. W.

doi:10.1016/s1734-1140(09)70172-0

Cited by 21 publications

(20 citation statements)

References 26 publications

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“…In our previous studies, magnesium sulfate administered in small doses significantly intensified the antinociceptive activity of morphine, fentanyl and buprenorphine in a model of toxic (vincristine) and diabetic neuropathy [1,2]. This study confirmed that magnesium at a low dose of 40 mg/kg when administered alone did not change STZ hypersensitivity, but markedly increased the analgesic action of morphine.…”

Section: Discussionsupporting

confidence: 79%

“…Therefore, coadministration of opioids with a compound that will increase the analgesic efficiency of these drugs, without concomitant intensification of their undesirable effects, will be of great clinical importance. As previously reported from this laboratory, magnesium administered in relatively low doses markedly potentiated opioid analgesia in neuropathic pain, in which the effectiveness of opioids is limited [1,2]. Since similar observations were also reported by other authors [3,4,5], it was of interest to further investigate the effect of magnesium ions (Mg 2+ ) on the analgesic activity of morphine as well as to compare it with the action of MK-801, a noncompetitive N-methyl- D -aspartate (NMDA) receptor antagonist.…”

Section: Introductionmentioning

confidence: 72%

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Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

Bujalska‐Zadrożny

Duda²

2014

Pharmacology

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As previously reported, magnesium ions (Mg²⁺) administered in relatively low doses markedly potentiated opioid analgesia in neuropathic pain, in which the effectiveness of opioids is limited. Considering that Mg²⁺ behaves like an N-methyl-D-aspartate receptor antagonist, the effect of this ion on the analgesic action of morphine was compared with that of MK-801. Acute pain was evoked by mechanical or thermal stimuli, whereas neuropathic hyperalgesia was induced by streptozotocin (STZ) administration. Magnesium sulphate (40 mg/kg i.p.) or MK-801 (0.05 mg/kg s.c.) administered alone did not modify the nociceptive threshold to acute stimuli or the streptozotocin hyperalgesia but significantly augmented the analgesic action of morphine (5 mg/kg i.p.). Furthermore, if these drugs (i.e. magnesium sulphate and MK-801) were applied concomitantly, a clear additive effect on the analgesic action of morphine occurred in both models of pain. Possible explanations of these observations are discussed.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 72%

Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

Bujalska‐Zadrożny

Duda²

2014

Pharmacology

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“…On the other hand, it has previously been approved that NMDA receptor antagonists have no significant effect on neuropathic pain induced by chemotherapeutic agents such as vincristine. Thus, it is obvious that the lithium mechanism of action here could not only be via NMDA [20,32]. Lithium plays an important role in microtubule dynamics and stability directly or indirectly via GSK3b [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Lithium Attenuates Peripheral Neuropathy Induced by Paclitaxel in Rats

Pourmohammadi

Alimoradi

Mehr

et al. 2011

Basic Clin Pharma Tox

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As a cancer chemotherapeutic agent, paclitaxel (Taxol Ò ) causes dose-related peripheral neuropathy in human beings. The mechanisms underlying this toxicity are currently unknown, and there are no validated treatments for its prevention or control. To assess whether lithium as a pre-treatment and at subtherapeutic dose could prevent the peripheral neuropathy produced by it, rats were treated with paclitaxel (2 mg ⁄ kg i.p. every other day for a total of 16 times) and ⁄ or lithium chloride (300 mg ⁄ l) via water supply. General toxicity and body-weight were measured regularly during the experiment. To evaluate the sensory and motor neuropathy hot-plate, open-field test and nerve conduction velocity were used. In rats treated with only paclitaxel, there was behavioural, electrophysiological and histological evidence of a mixed sensorimotor neuropathy after 16 injections. Lithium robustly reduced the rate of mortality and general toxicity. Paclitaxel-induced sensorimotor neuropathy was significantly improved as indicated by changes in hotplate latency, total distance moved and a significant increase in sciatic, sural and tail sensory or motor nerve conduction velocity. The same results were observed in histopathological examinations; however, dorsal root ganglion neurons did not significantly change in the paclitaxel-treated groups. These results suggest that lithium, at subtherapeutic doses, can prevent both motor and sensory components of paclitaxel neuropathy in rats. Thus, lithium at these doses, as an inexpensive and relatively safe salt, may be useful clinically in preventing the neuropathy induced by paclitaxel treatment.Paclitaxel is an effective anti-tumour agent initially isolated from the bark of the pacific yew tree, Taxus brevifolia, and is regularly used to treat long, ovarian cancer either by itself or in combination with other anti-tumour agents [1][2][3]. Paclitaxel causes excessive tubulin polymerization leading to mitotic arrest and thus inducing apoptosis in dividing cells [4].Microtubules play an important role in cellular functions such as membrane and cellular scaffolding, intracellular transport of organelles or proteins and transmission of signals initiated at cell surface receptors. Thus, microtubules interfering agents like vincristine or paclitaxel may disturb non-neoplastic cells such as nerves and finally cause apoptosis. Hence, peripheral neuropathy is one of the most frequent side effects of these two drugs that usually result in dose modification and changes in the treatment plan [5][6][7][8].As a mood stabilizer, lithium is commonly prescribed for bipolar disorders, and although its mechanism of action remains unknown, it is well established that lithium exerts some of its therapeutic effects through G-protein-coupled pathway, glycogen synthase kinase-3 (GSK3b), inositol monophopsphate and nitric oxide-dependent pathways and augmentation of serotonin function in the central nervous system [9,10]. Previous studies have reported that lithium has neuroprotective effects. The...

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“…In contrast, another study found opioid agonists, such as morphine (5 mg/kg, i.p.) administered alone on 5 consecutive days, did not modify hyperalgesia (Bujalska et al, 2009). This discrepancy could be due to differences in study protocol and animal model.…”

Section: Discussionmentioning

confidence: 89%

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

Nouri¹

2012

Afr. J. Pharm. Pharmacol.

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Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus, effective therapeutic strategy is required. In this study, the antinociceptive effect of Matricaria chamomilla (MC) hydroalcoholic extract and morphine on vincristine-induced peripheral neuropathy model in mice has been investigated. Experiments were performed on 60 Naval Medical Research Institute (NMRI) male mice. Mouse subsequently received daily intraperitoneal and intravenal injections of vincristine sulfate, saline and MC hydroalcoholic extract over 12 days, immediately following behavioral testing. For assessment of pain, formalin test was preformed. The effects of MC, morphine and vehicle (saline) 30 min before formalin test on vincristine-induced neuropathy were evaluated. Administration of MC before formalin injection showed significant (P < 0.05) decrease of pain responses in both phases. Administration of vincristine produced significant (Pm < 0.05) increase in pain response in second phase of formalin test. Injection of MC and vincristine together has shown that MC is able to decrease the vincristine induced pain significantly (P < 0.05). Morphine decreased vincristine induced pain test significantly (P < 0.05). In comparison, morphine has analgesic effects in the first phase and MC has anti-inflammatory effects in the second phase of formalin test significantly (P < 0.05). These results suggest that MC may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.

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Magnesium ions and opioid agonists in vincristine-induced neuropathy

Cited by 21 publications

References 26 publications

Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

Lithium Attenuates Peripheral Neuropathy Induced by Paclitaxel in Rats

Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice

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